Liver X Receptor Protects against Liver Injury in Sepsis Caused by Rodent Cecal Ligation and Puncture

Background: Liver X receptor (LXR) is a transcription factor of the nuclear receptor family, regulating genes involved in metabolism, inflammation, and apoptosis. In the present investigation, we examined the role of LXR in organ injury and systemic inflammation in rodent models of polymicrobial per...

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Veröffentlicht in:	Surgical infections 2011-08, Vol.12 (4), p.283-289
Hauptverfasser:	Wang, Yun Yong, Ryg, Una, Dahle, Maria K., Steffensen, Knut R., Thiemermann, Christoph, Chaudry, Irshad H., Reinholt, Finn P., Collins, Jon L., Nebb, Hilde I., Aasen, Ansgar O., Gustafsson, Jan-Åke, Wang, Jacob E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal experimentation Animals Cecum - injuries Complications and side effects Disease Models, Animal Gene Expression Profiling Health aspects Hormone receptors Ligation Ligature (Surgery) Liver diseases Liver Failure - immunology Liver X Receptors Male Mice Mice, Inbred C57BL Mice, Knockout Original Articles Orphan Nuclear Receptors - biosynthesis Prevention Prognosis Punctures Rats Rats, Wistar Risk factors Rodent Diseases - immunology Sepsis Sepsis - complications
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