Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as the internalization of growth factors and receptors, entry of pathogens, and synaptic transmission. Within the endocytic network, clathrin functions as a central organizing platform for coated pit assembly and di...

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Veröffentlicht in:	Cell 2011-08, Vol.146 (3), p.471-484
Hauptverfasser:	von Kleist, Lisa, Stahlschmidt, Wiebke, Bulut, Haydar, Gromova, Kira, Puchkov, Dmytro, Robertson, Mark J., MacGregor, Kylie A., Tomlin, Nikolay, Pechstein, Arndt, Chau, Ngoc, Chircop, Megan, Sakoff, Jennette, von Kries, Jens Peter, Saenger, Wolfram, Kräusslich, Hans-Georg, Shupliakov, Oleg, Robinson, Phillip J., McCluskey, Adam, Haucke, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 2 - metabolism Animals Cells, Cultured clathrin Clathrin - chemistry Clathrin - metabolism Coated Pits, Cell-Membrane - drug effects Coated Pits, Cell-Membrane - metabolism Crystallography, X-Ray Cytological Techniques - methods dissociation dynamins Dynamins - metabolism Endocytosis growth factors Human immunodeficiency virus Humans Mice pathogens Protein Structure, Tertiary receptors Signal Transduction Small Molecule Libraries Synapses - metabolism Synapses - ultrastructure synaptic transmission synaptic vesicles viruses X-ray diffraction
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