Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells

► Atorvastatin administration could ameliorate EAN by immune regulation. ► Atorvastatin decreased the numbers of IFN-γ + and IL-17 + cells in sciatic nerves. ► Atorvastatin decreased the CD80 expression in lymph nodes mononuclear cells. ► Atorvastatin up-regulated the number of Treg cells. ► Atorvas...

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Veröffentlicht in:	Cellular immunology 2011, Vol.271 (2), p.455-461
Hauptverfasser:	Li, Xiao-Li, Dou, Ying-Chun, Liu, Ying, Shi, Chang-Wen, Cao, Li-Li, Zhang, Xiu-Qing, Zhu, Jie, Duan, Rui-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atorvastatin Atorvastatin Calcium Cattle CD80 Cytokines - metabolism Experimental autoimmune neuritis Female Guillain-Barre Syndrome - drug therapy Guillain-Barre Syndrome - immunology Heptanoic Acids - pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology IL-17 Immunization Interferon-gamma - metabolism Interleukin-17 - metabolism Medicin och hälsovetenskap Myelin Sheath - immunology Neuritis, Autoimmune, Experimental - drug therapy Neuritis, Autoimmune, Experimental - immunology Neuritis, Autoimmune, Experimental - pathology Pyrroles - pharmacology Rats Rats, Inbred Lew Sciatic Nerve - drug effects Sciatic Nerve - pathology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - drug effects Th1 Cells - immunology Th17 Cells - drug effects Th17 Cells - immunology Treg cells
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