Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells
► Atorvastatin administration could ameliorate EAN by immune regulation. ► Atorvastatin decreased the numbers of IFN-γ + and IL-17 + cells in sciatic nerves. ► Atorvastatin decreased the CD80 expression in lymph nodes mononuclear cells. ► Atorvastatin up-regulated the number of Treg cells. ► Atorvas...
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| Veröffentlicht in: | Cellular immunology 2011, Vol.271 (2), p.455-461 |
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| creator | Li, Xiao-Li Dou, Ying-Chun Liu, Ying Shi, Chang-Wen Cao, Li-Li Zhang, Xiu-Qing Zhu, Jie Duan, Rui-Sheng |
| description | ► Atorvastatin administration could ameliorate EAN by immune regulation. ► Atorvastatin decreased the numbers of IFN-γ
+ and IL-17
+ cells in sciatic nerves. ► Atorvastatin decreased the CD80 expression in lymph nodes mononuclear cells. ► Atorvastatin up-regulated the number of Treg cells. ► Atorvastatin decreased the levels of IFN-γ in MNC culture supernatants.
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain–Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund’s adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ
+ and IL-17
+ cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25
+Foxp3
+ cells in mononuclear cells (MNC), and decreased the levels of IFN-γ in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future. |
| doi_str_mv | 10.1016/j.cellimm.2011.08.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_542123</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0008874911002164</els_id><sourcerecordid>898840623</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-1b0b7eeb2f92566257be90bfaa32ef3d0da155df477ffb6170e5648f0bd4c6623</originalsourceid><addsrcrecordid>eNqFkkFv1DAQhSMEotvCTwD5xinp2HFi54SqCihSJS7lbNnxBLxN4sV2WvbAf8fbTcsJ9WDZsr73ZsZ-RfGOQkWBtufbqsdxdNNUMaC0AlkBbV4UGwodlIy29ctiAwCylIJ3J8VpjFvIIO_gdXHCqJQdZe2m-HORfLjTMenkZqInHJ0POmEk-HuHwU04Jz0SvSSfay0zkhmX4JKLxOyJxT6gjmjJzU96npcg_T75WzdnAz1bsuzKgD-WMTtmhqxnH_bk0H18U7wa9Bjx7bqfFd8_f7q5vCqvv335enlxXfZc8lRSA0YgGjZ0rGlb1giDHZhB65rhUFuwmjaNHbgQw2BaKgCblssBjOV95uuzojz6xnvcLUbt8mA67JXXTq1Xt_mEquGMsjrz3X_5XfD2n-hRmFW8FuJB--GozeCvBWNSk4uHafWMfomqA1a3UrDmWVJ2UnJoHzybI9kHH2PA4akjCuoQB7VVaxzUIQ4KpMpxyLr3a4XFTGifVI__n4GPRwDz6985DCr2DucerQvYJ2W9e6bEX6lYzRo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>898840623</pqid></control><display><type>article</type><title>Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Li, Xiao-Li ; Dou, Ying-Chun ; Liu, Ying ; Shi, Chang-Wen ; Cao, Li-Li ; Zhang, Xiu-Qing ; Zhu, Jie ; Duan, Rui-Sheng</creator><creatorcontrib>Li, Xiao-Li ; Dou, Ying-Chun ; Liu, Ying ; Shi, Chang-Wen ; Cao, Li-Li ; Zhang, Xiu-Qing ; Zhu, Jie ; Duan, Rui-Sheng</creatorcontrib><description>► Atorvastatin administration could ameliorate EAN by immune regulation. ► Atorvastatin decreased the numbers of IFN-γ
+ and IL-17
+ cells in sciatic nerves. ► Atorvastatin decreased the CD80 expression in lymph nodes mononuclear cells. ► Atorvastatin up-regulated the number of Treg cells. ► Atorvastatin decreased the levels of IFN-γ in MNC culture supernatants.
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain–Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund’s adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ
+ and IL-17
+ cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25
+Foxp3
+ cells in mononuclear cells (MNC), and decreased the levels of IFN-γ in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future.</description><identifier>ISSN: 0008-8749</identifier><identifier>ISSN: 1090-2163</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/j.cellimm.2011.08.015</identifier><identifier>PMID: 21889126</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Atorvastatin ; Atorvastatin Calcium ; Cattle ; CD80 ; Cytokines - metabolism ; Experimental autoimmune neuritis ; Female ; Guillain-Barre Syndrome - drug therapy ; Guillain-Barre Syndrome - immunology ; Heptanoic Acids - pharmacology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; IL-17 ; Immunization ; Interferon-gamma - metabolism ; Interleukin-17 - metabolism ; Medicin och hälsovetenskap ; Myelin Sheath - immunology ; Neuritis, Autoimmune, Experimental - drug therapy ; Neuritis, Autoimmune, Experimental - immunology ; Neuritis, Autoimmune, Experimental - pathology ; Pyrroles - pharmacology ; Rats ; Rats, Inbred Lew ; Sciatic Nerve - drug effects ; Sciatic Nerve - pathology ; T-Lymphocyte Subsets - drug effects ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th17 Cells - drug effects ; Th17 Cells - immunology ; Treg cells</subject><ispartof>Cellular immunology, 2011, Vol.271 (2), p.455-461</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-1b0b7eeb2f92566257be90bfaa32ef3d0da155df477ffb6170e5648f0bd4c6623</citedby><cites>FETCH-LOGICAL-c484t-1b0b7eeb2f92566257be90bfaa32ef3d0da155df477ffb6170e5648f0bd4c6623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cellimm.2011.08.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21889126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:123437723$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xiao-Li</creatorcontrib><creatorcontrib>Dou, Ying-Chun</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Shi, Chang-Wen</creatorcontrib><creatorcontrib>Cao, Li-Li</creatorcontrib><creatorcontrib>Zhang, Xiu-Qing</creatorcontrib><creatorcontrib>Zhu, Jie</creatorcontrib><creatorcontrib>Duan, Rui-Sheng</creatorcontrib><title>Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>► Atorvastatin administration could ameliorate EAN by immune regulation. ► Atorvastatin decreased the numbers of IFN-γ
+ and IL-17
+ cells in sciatic nerves. ► Atorvastatin decreased the CD80 expression in lymph nodes mononuclear cells. ► Atorvastatin up-regulated the number of Treg cells. ► Atorvastatin decreased the levels of IFN-γ in MNC culture supernatants.
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain–Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund’s adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ
+ and IL-17
+ cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25
+Foxp3
+ cells in mononuclear cells (MNC), and decreased the levels of IFN-γ in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future.</description><subject>Animals</subject><subject>Atorvastatin</subject><subject>Atorvastatin Calcium</subject><subject>Cattle</subject><subject>CD80</subject><subject>Cytokines - metabolism</subject><subject>Experimental autoimmune neuritis</subject><subject>Female</subject><subject>Guillain-Barre Syndrome - drug therapy</subject><subject>Guillain-Barre Syndrome - immunology</subject><subject>Heptanoic Acids - pharmacology</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>IL-17</subject><subject>Immunization</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-17 - metabolism</subject><subject>Medicin och hälsovetenskap</subject><subject>Myelin Sheath - immunology</subject><subject>Neuritis, Autoimmune, Experimental - drug therapy</subject><subject>Neuritis, Autoimmune, Experimental - immunology</subject><subject>Neuritis, Autoimmune, Experimental - pathology</subject><subject>Pyrroles - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Sciatic Nerve - drug effects</subject><subject>Sciatic Nerve - pathology</subject><subject>T-Lymphocyte Subsets - drug effects</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Th17 Cells - drug effects</subject><subject>Th17 Cells - immunology</subject><subject>Treg cells</subject><issn>0008-8749</issn><issn>1090-2163</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFv1DAQhSMEotvCTwD5xinp2HFi54SqCihSJS7lbNnxBLxN4sV2WvbAf8fbTcsJ9WDZsr73ZsZ-RfGOQkWBtufbqsdxdNNUMaC0AlkBbV4UGwodlIy29ctiAwCylIJ3J8VpjFvIIO_gdXHCqJQdZe2m-HORfLjTMenkZqInHJ0POmEk-HuHwU04Jz0SvSSfay0zkhmX4JKLxOyJxT6gjmjJzU96npcg_T75WzdnAz1bsuzKgD-WMTtmhqxnH_bk0H18U7wa9Bjx7bqfFd8_f7q5vCqvv335enlxXfZc8lRSA0YgGjZ0rGlb1giDHZhB65rhUFuwmjaNHbgQw2BaKgCblssBjOV95uuzojz6xnvcLUbt8mA67JXXTq1Xt_mEquGMsjrz3X_5XfD2n-hRmFW8FuJB--GozeCvBWNSk4uHafWMfomqA1a3UrDmWVJ2UnJoHzybI9kHH2PA4akjCuoQB7VVaxzUIQ4KpMpxyLr3a4XFTGifVI__n4GPRwDz6985DCr2DucerQvYJ2W9e6bEX6lYzRo</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Li, Xiao-Li</creator><creator>Dou, Ying-Chun</creator><creator>Liu, Ying</creator><creator>Shi, Chang-Wen</creator><creator>Cao, Li-Li</creator><creator>Zhang, Xiu-Qing</creator><creator>Zhu, Jie</creator><creator>Duan, Rui-Sheng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>2011</creationdate><title>Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells</title><author>Li, Xiao-Li ; Dou, Ying-Chun ; Liu, Ying ; Shi, Chang-Wen ; Cao, Li-Li ; Zhang, Xiu-Qing ; Zhu, Jie ; Duan, Rui-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-1b0b7eeb2f92566257be90bfaa32ef3d0da155df477ffb6170e5648f0bd4c6623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Atorvastatin</topic><topic>Atorvastatin Calcium</topic><topic>Cattle</topic><topic>CD80</topic><topic>Cytokines - metabolism</topic><topic>Experimental autoimmune neuritis</topic><topic>Female</topic><topic>Guillain-Barre Syndrome - drug therapy</topic><topic>Guillain-Barre Syndrome - immunology</topic><topic>Heptanoic Acids - pharmacology</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>IL-17</topic><topic>Immunization</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukin-17 - metabolism</topic><topic>Medicin och hälsovetenskap</topic><topic>Myelin Sheath - immunology</topic><topic>Neuritis, Autoimmune, Experimental - drug therapy</topic><topic>Neuritis, Autoimmune, Experimental - immunology</topic><topic>Neuritis, Autoimmune, Experimental - pathology</topic><topic>Pyrroles - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Sciatic Nerve - drug effects</topic><topic>Sciatic Nerve - pathology</topic><topic>T-Lymphocyte Subsets - drug effects</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th17 Cells - drug effects</topic><topic>Th17 Cells - immunology</topic><topic>Treg cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiao-Li</creatorcontrib><creatorcontrib>Dou, Ying-Chun</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Shi, Chang-Wen</creatorcontrib><creatorcontrib>Cao, Li-Li</creatorcontrib><creatorcontrib>Zhang, Xiu-Qing</creatorcontrib><creatorcontrib>Zhu, Jie</creatorcontrib><creatorcontrib>Duan, Rui-Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiao-Li</au><au>Dou, Ying-Chun</au><au>Liu, Ying</au><au>Shi, Chang-Wen</au><au>Cao, Li-Li</au><au>Zhang, Xiu-Qing</au><au>Zhu, Jie</au><au>Duan, Rui-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>2011</date><risdate>2011</risdate><volume>271</volume><issue>2</issue><spage>455</spage><epage>461</epage><pages>455-461</pages><issn>0008-8749</issn><issn>1090-2163</issn><eissn>1090-2163</eissn><abstract>► Atorvastatin administration could ameliorate EAN by immune regulation. ► Atorvastatin decreased the numbers of IFN-γ
+ and IL-17
+ cells in sciatic nerves. ► Atorvastatin decreased the CD80 expression in lymph nodes mononuclear cells. ► Atorvastatin up-regulated the number of Treg cells. ► Atorvastatin decreased the levels of IFN-γ in MNC culture supernatants.
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain–Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund’s adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ
+ and IL-17
+ cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25
+Foxp3
+ cells in mononuclear cells (MNC), and decreased the levels of IFN-γ in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>21889126</pmid><doi>10.1016/j.cellimm.2011.08.015</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cellular immunology, 2011, Vol.271 (2), p.455-461 |
| issn | 0008-8749 1090-2163 1090-2163 |
| language | eng |
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| subjects | Animals Atorvastatin Atorvastatin Calcium Cattle CD80 Cytokines - metabolism Experimental autoimmune neuritis Female Guillain-Barre Syndrome - drug therapy Guillain-Barre Syndrome - immunology Heptanoic Acids - pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology IL-17 Immunization Interferon-gamma - metabolism Interleukin-17 - metabolism Medicin och hälsovetenskap Myelin Sheath - immunology Neuritis, Autoimmune, Experimental - drug therapy Neuritis, Autoimmune, Experimental - immunology Neuritis, Autoimmune, Experimental - pathology Pyrroles - pharmacology Rats Rats, Inbred Lew Sciatic Nerve - drug effects Sciatic Nerve - pathology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - drug effects Th1 Cells - immunology Th17 Cells - drug effects Th17 Cells - immunology Treg cells |
| title | Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells |
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