Obesity-Related Derangements of Coagulation and Fibrinolysis: A Study of Obesity-Discordant Monozygotic Twin Pairs

Coagulation and fibrinolytic activities are under strong genetic control. We studied the effects of acquired obesity, independent of genetic factors on coagulation and fibrinolysis activities in obesity‐discordant healthy monozygotic (MZ) twin pairs. Fourteen obesity‐discordant (BMI within‐pair diff...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2012-01, Vol.20 (1), p.88-94
Hauptverfasser:	Kaye, Sanna M., Pietiläinen, Kirsi H., Kotronen, Anna, Joutsi‐Korhonen, Lotta, Kaprio, Jaakko, Yki‐Järvinen, Hannele, Silveira, Angela, Hamsten, Anders, Lassila, Riitta, Rissanen, Aila
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Fat - metabolism Absorptiometry, Photon Adult Blood Coagulation Blood Coagulation Factors - metabolism Body Composition Body Mass Index C-Reactive Protein - metabolism Coagulation Factor IX - metabolism Factor XI - metabolism Factor XII - metabolism Fasting Fatty Liver - complications Fatty Liver - metabolism Female Fibrinogen - metabolism Fibrinolysis Genetic Predisposition to Disease - genetics Genetics Glucose Clamp Technique Humans Insulin Resistance Magnetic Resonance Imaging Male Medicin och hälsovetenskap Obesity Obesity - blood Obesity - complications Obesity - metabolism Plasminogen Activator Inhibitor 1 - metabolism Thrombosis - blood Thrombosis - etiology Thrombosis - metabolism Twins Twins, Monozygotic
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Zusammenfassung:	Coagulation and fibrinolytic activities are under strong genetic control. We studied the effects of acquired obesity, independent of genetic factors on coagulation and fibrinolysis activities in obesity‐discordant healthy monozygotic (MZ) twin pairs. Fourteen obesity‐discordant (BMI within‐pair difference >3 kg/m2) and 10 concordant (BMI difference
ISSN:	1930-7381 1930-739X 1930-739X
DOI:	10.1038/oby.2011.287