IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection

Chagas' disease is a zoonosis prevalent in Latin America that is caused by the protozoan Trypanosoma cruzi. The immunopathogenesis of cardiomyopathy, the main clinical problem in Chagas' disease, has been extensively studied but is still poorly understood. In this study, we systematically...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-01, Vol.188 (2), p.649-660
Hauptverfasser:	Roffê, Ester, Rothfuchs, Antonio Gigliotti, Santiago, Helton C, Marino, Ana Paula M P, Ribeiro-Gomes, Flavia L, Eckhaus, Michael, Antonelli, Lis R V, Murphy, Philip M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adoptive Transfer Animals Chagas Disease - mortality Chagas Disease - parasitology Chagas Disease - prevention & control Disease Models, Animal Interleukin-10 - deficiency Interleukin-10 - physiology Interleukin-10 - therapeutic use Male Medicin och hälsovetenskap Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Myocarditis - mortality Myocarditis - parasitology Myocarditis - prevention & control Parasitemia - immunology Parasitemia - mortality Parasitemia - parasitology Survival Analysis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - parasitology Trypanosoma cruzi Trypanosoma cruzi - immunology
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Beschreibung
Zusammenfassung:	Chagas' disease is a zoonosis prevalent in Latin America that is caused by the protozoan Trypanosoma cruzi. The immunopathogenesis of cardiomyopathy, the main clinical problem in Chagas' disease, has been extensively studied but is still poorly understood. In this study, we systematically compared clinical, microbiologic, pathologic, immunologic, and molecular parameters in two mouse models with opposite susceptibility to acute myocarditis caused by the myotropic Colombiana strain of T. cruzi: C3H/HeSnJ (100% mortality, uncontrolled parasitism) and C57BL/6J (
ISSN:	0022-1767 1550-6606 1550-6606
DOI:	10.4049/jimmunol.1003845