Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus

Inherited deficiencies of several complement components strongly predispose to systemic lupus erythematosus (SLE) while deficiencies of complement inhibitors are found in kidney diseases such as atypical hemolytic uremic syndrome (aHUS). The exons of complement inhibitor genes CD46 and CFH (factor H...

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Veröffentlicht in:	Arthritis research & therapy 2011-01, Vol.13 (6), p.R206-R206
Hauptverfasser:	Jönsen, Andreas, Nilsson, Sara C, Ahlqvist, Emma, Svenungsson, Elisabet, Gunnarsson, Iva, Eriksson, Karin G, Bengtsson, Anders, Zickert, Agneta, Eloranta, Maija-Leena, Truedsson, Lennart, Rönnblom, Lars, Nordmark, Gunnel, Sturfelt, Gunnar, Blom, Anna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age of Onset Clinical Medicine Cohort Studies complement Complement Factor H - genetics Dermatologi och venerologi, klinisk genetik, invärtesmedicin Dermatology and venerology,clinical genetics, internal medicine Female Genotype Haplotypes Humans Internal medicine Invärtesmedicin Klinisk medicin Logistic Models Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - genetics Male Medical and Health Sciences MEDICIN Medicin och hälsovetenskap MEDICINE Membrane Cofactor Protein - genetics Multivariate Analysis Mutation Nephritis - epidemiology Nephritis - genetics Polymorphism, Genetic Reumatologi Reumatologi och inflammation Rheumatology Rheumatology and Autoimmunity Sweden - epidemiology systemic lupus erythematosus Young Adult
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