Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and progenitor cells; however, direct cellular targets and specific functions of Notch signals had not been identified. We show here in mice that Notch directly targets the crypt base columnar (CBC) cell to...

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Veröffentlicht in:	Development (Cambridge) 2012-02, Vol.139 (3), p.488-497
Hauptverfasser:	VanDussen, Kelli L, Carulli, Alexis J, Keeley, Theresa M, Patel, Sanjeevkumar R, Puthoff, Brent J, Magness, Scott T, Tran, Ivy T, Maillard, Ivan, Siebel, Christian, Kolterud, Åsa, Grosse, Ann S, Gumucio, Deborah L, Ernst, Stephen A, Tsai, Yu-Hwai, Dempsey, Peter J, Samuelson, Linda C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Base Sequence Basic Helix-Loop-Helix Transcription Factors - genetics Cell Differentiation Cell Proliferation Development and Stem Cells Gene Expression Regulation Goblet Cells - metabolism Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism Intestine, Small - cytology Intestine, Small - drug effects Intestine, Small - metabolism Mice Mice, Inbred C57BL Molecular Sequence Data Organ Culture Techniques Paneth Cells - metabolism Promoter Regions, Genetic Receptor, Notch1 - antagonists & inhibitors Receptor, Notch1 - metabolism Receptor, Notch2 - antagonists & inhibitors Receptor, Notch2 - metabolism Signal Transduction Stem Cells - cytology Stem Cells - physiology
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