Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

Ribonucleotide reductase (RNR) activity requires an electron donor, which in bacteria, yeast, and plants is usually either reduced thioredoxin (Trx) or reduced glutaredoxin. Mice lacking glutathione reductase are viable and, although mice lacking thioredoxin reductase 1 (TrxR1) are embryonic-lethal,...

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Veröffentlicht in:	Free radical biology & medicine 2012-02, Vol.52 (4), p.803-810
Hauptverfasser:	Prigge, Justin R., Eriksson, Sofi, Iverson, Sonya V., Meade, Tesia A., Capecchi, Mario R., Arnér, Elias S.J., Schmidt, Edward E.
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles Animals bacteria Base Sequence Buthionine sulfoximine Cell Proliferation DNA biosynthesis DNA Replication enzyme activity Enzymes Exons Glutaredoxin Glutathione Glutathione - metabolism Glutathione - physiology Glutathione Disulfide - metabolism glutathione reductase glutathione-disulfide reductase Hepatocyte Hepatocytes Hepatocytes - enzymology Hepatocytes - metabolism Hepatocytes - physiology Heterozygote Histones - metabolism Isoenzymes - genetics Isoenzymes - metabolism juveniles Liver Liver - cytology Liver - enzymology Liver - growth & development Liver - metabolism Medicin och hälsovetenskap messenger RNA Mice Mice, Inbred C57BL Molecular Sequence Data Mouse mRNA Proliferating Cell Nuclear Antigen - metabolism Replication Ribonucleoside-triphosphate reductase ribonucleotide reductase Thioredoxin Thioredoxin reductase Thioredoxin Reductase 1 - deficiency Thioredoxin Reductase 1 - genetics Thioredoxin Reductase 1 - metabolism Thioredoxin Reductase 2 - genetics Thioredoxin Reductase 2 - metabolism Thioredoxin-disulfide reductase Thioredoxins - metabolism Transcription, Genetic yeasts
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