Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells

ROR1 is a receptor tyrosine kinase (RTK) recently identified to be overexpressed at the gene and protein levels in chronic lymphocytic leukemia (CLL). Monoclonal antibodies (MAbs) against RTKs have been successfully applied for therapy of solid tumors. We generated five MAbs against the Ig ( n =1),...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2012-06, Vol.26 (6), p.1348-1355
Hauptverfasser:	Daneshmanesh, A H, Hojjat-Farsangi, M, Khan, A S, Jeddi-Tehrani, M, Akhondi, M M, Bayat, A A, Ghods, R, Mahmoudi, A-R, Hadavi, R, Österborg, A, Shokri, F, Rabbani, H, Mellstedt, H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2325 631/80/82/23 692/699/67/1990/283/1895 Animals Antibodies, Monoclonal - pharmacology Antibody Formation Antibody-Dependent Cell Cytotoxicity Apoptosis Apoptosis - immunology Biological and medical sciences Cancer Research Care and treatment Caspase-8 Caspase-9 Chronic lymphocytic leukemia Critical Care Medicine Crosslinking Cytotoxicity Effector cells Epitopes Genetic aspects Health care Hematologic and hematopoietic diseases Hematology Humans Immunization Immunoglobulin G Immunoglobulins Immunotherapy Intensive Internal Medicine Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Medical prognosis Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Monoclonal antibodies Oncology original-article Peptide Fragments - immunology Peptides Physiological aspects Protein-tyrosine kinase receptors Proteins Receptor Tyrosine Kinase-like Orphan Receptors - immunology Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Ribose Rituximab Solid tumors Toxicity Tumor Cells, Cultured Tumors Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!