Basal cell carcinoma - molecular biology and potential new therapies
Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has...
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| Veröffentlicht in: | The Journal of clinical investigation 2012-02, Vol.122 (2), p.455-463 |
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| creator | Kasper, Maria Jaks, Viljar Hohl, Daniel Toftgård, Rune |
| description | Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has opened the way for exciting progress toward understanding BCC biology and translation of this knowledge to the clinic. Genetic mouse models closely mimicking human BCCs have provided answers about the tumor cell of origin, and inhibition of Hedgehog signaling is emerging as a potentially useful targeted therapy for patients with advanced or multiple BCCs that have hitherto lacked effective treatment. |
| doi_str_mv | 10.1172/JCI58779 |
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The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has opened the way for exciting progress toward understanding BCC biology and translation of this knowledge to the clinic. Genetic mouse models closely mimicking human BCCs have provided answers about the tumor cell of origin, and inhibition of Hedgehog signaling is emerging as a potentially useful targeted therapy for patients with advanced or multiple BCCs that have hitherto lacked effective treatment.</description><identifier>ISSN: 0021-9738</identifier><identifier>ISSN: 1558-8238</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI58779</identifier><identifier>PMID: 22293184</identifier><language>eng</language><publisher>United States: American Society for Clinical Investigation</publisher><subject>Animals ; Biomedical research ; Cancer therapies ; Carcinoma, Basal Cell - etiology ; Carcinoma, Basal Cell - pathology ; Carcinoma, Basal Cell - physiopathology ; Carcinoma, Basal Cell - therapy ; Clinical Trials as Topic ; Disease Models, Animal ; Hedgehog Proteins - genetics ; Hedgehog Proteins - metabolism ; Humans ; Medicin och hälsovetenskap ; Molecular Biology ; Radiation ; Review Series ; Signal Transduction - physiology ; Skin - pathology ; Skin - radiation effects ; Skin Neoplasms - etiology ; Skin Neoplasms - pathology ; Skin Neoplasms - physiopathology ; Skin Neoplasms - therapy ; Tumors ; Ultraviolet Rays - adverse effects</subject><ispartof>The Journal of clinical investigation, 2012-02, Vol.122 (2), p.455-463</ispartof><rights>Copyright American Society for Clinical Investigation Feb 2012</rights><rights>Copyright © 2012, American Society for Clinical Investigation 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-85eadcfbd0a25ca9e16cecfa3058900f30e61c31aa1fb389bb7b3b761f36b73c3</citedby><cites>FETCH-LOGICAL-c486t-85eadcfbd0a25ca9e16cecfa3058900f30e61c31aa1fb389bb7b3b761f36b73c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266783/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266783/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,552,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22293184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:123993796$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasper, Maria</creatorcontrib><creatorcontrib>Jaks, Viljar</creatorcontrib><creatorcontrib>Hohl, Daniel</creatorcontrib><creatorcontrib>Toftgård, Rune</creatorcontrib><title>Basal cell carcinoma - molecular biology and potential new therapies</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. 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| source | MEDLINE; SWEPUB Freely available online; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biomedical research Cancer therapies Carcinoma, Basal Cell - etiology Carcinoma, Basal Cell - pathology Carcinoma, Basal Cell - physiopathology Carcinoma, Basal Cell - therapy Clinical Trials as Topic Disease Models, Animal Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Medicin och hälsovetenskap Molecular Biology Radiation Review Series Signal Transduction - physiology Skin - pathology Skin - radiation effects Skin Neoplasms - etiology Skin Neoplasms - pathology Skin Neoplasms - physiopathology Skin Neoplasms - therapy Tumors Ultraviolet Rays - adverse effects |
| title | Basal cell carcinoma - molecular biology and potential new therapies |
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