Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimer’s Disease

Background/Aims: Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline in patients with Alzheimer’s disease (AD). Targeted delivery of exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on the basal forebra...

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Veröffentlicht in:	Dementia and geriatric cognitive disorders 2012-01, Vol.33 (1), p.18-28
Hauptverfasser:	Eriksdotter-Jönhagen, Maria, Linderoth, Bengt, Lind, Göran, Aladellie, Layth, Almkvist, Ove, Andreasen, Niels, Blennow, Kaj, Bogdanovic, Nenad, Jelic, Vesna, Kadir, Ahmadul, Nordberg, Agneta, Sundström, Erik, Wahlund, Lars-Olof, Wall, Anders, Wiberg, Maria, Winblad, Bengt, Seiger, Åke, Almqvist, Per, Wahlberg, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	80 and over administration & dosage adverse effects Aged Aged, 80 and over Alzheimer Disease Alzheimer Disease - drug therapy Alzheimer's disease Autopsy Basal forebrain Biological and medical sciences Biopsy Cell Line Cerebral Cortex Cerebral Cortex - pathology Cognition Cognition - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship Dose-Response Relationship, Drug Drug drug therapy Electroencephalography Encapsulated cell biodelivery Feasibility Studies Female Humans Implantable Infusion Pumps Infusion Pumps, Implantable - adverse effects Magnetic Resonance Imaging Male Medical sciences metabolism Middle Aged Nerve growth factor Nerve Growth Factors Nerve Growth Factors - administration & dosage Nerve Growth Factors - pharmacokinetics Nerve Growth Factors - therapeutic use Neurologi Neurology Neuropsychological Tests Neurosciences Neurosurgery Neurosurgical Procedures Neurovetenskaper Nicotine Nicotine - pharmacokinetics Nicotinic Original Research Article pathology pharmacokinetics physiology Positron-Emission Tomography Prosencephalon Prosencephalon - physiology Psychology Psykologi Receptors Receptors, Nicotinic - metabolism SAMHÄLLSVETENSKAP SOCIAL SCIENCES Socialvetenskap therapeutic use Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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