The immunobiology of Ro52 (TRIM21) in autoimmunity: A critical review

Abstract Ro52 is a common target of circulating autoantibodies in autoimmune disease. Data indicate that anti-Ro52 antibodies are associated with distinct clinical manifestations. It is therefore of major interest to understand how it becomes an antigenic target and what cells express this protein u...

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Veröffentlicht in:	Journal of autoimmunity 2012-08, Vol.39 (1), p.77-82
Hauptverfasser:	Oke, Vilija, Wahren-Herlenius, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autoantibodies Autoantigen Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmunity Biological and medical sciences CLE Data processing Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune response Immune system Inflammation Interferon Interferon regulatory factor 3 Interferon regulatory factor 7 Interferon Regulatory Factor-3 - metabolism Interferon Regulatory Factor-7 - metabolism Interferon Regulatory Factors - metabolism Medical sciences Nuclei Reviews Ribonucleoproteins - immunology Ribonucleoproteins - metabolism Ro52 Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sjögren’s syndrome SLE Transcription factors TRIM21 Ubiquitin-protein ligase Ubiquitination
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