Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study
Aim: To perform a nationwide investigation of paediatric drug use at Swedish hospitals, including an analysis of off‐label drug use. Methods: All paediatric hospitals in Sweden were invited to register all prescriptions to children, aged between 0 and 18, during two separate 2‐day‐periods in 2008....
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| Veröffentlicht in: | Acta Paediatrica 2012-07, Vol.101 (7), p.772-778 |
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| creator | Kimland, E Nydert, P Odlind, V Böttiger, Y Lindemalm, S |
| description | Aim: To perform a nationwide investigation of paediatric drug use at Swedish hospitals, including an analysis of off‐label drug use.
Methods: All paediatric hospitals in Sweden were invited to register all prescriptions to children, aged between 0 and 18, during two separate 2‐day‐periods in 2008. Data were reported and analysed with respect to licence status and proportion of and reasons for off‐label drug use.
Results: Data on 11 294 prescriptions to 2947 paediatric patients were received. Drugs associated with pain relief, infection, prematurity, nutrition and surgery or anaesthesia were most commonly used. Paracetamol was the most frequently used drug on‐label and also among the most commonly used off‐label drugs. Nearly half (49%) of all administered prescriptions concerned unlicensed drugs, off‐label drugs or extemporaneously prepared drugs. The corresponding rate among neonates was 69%. Lack of paediatric information in the Summary of Product Characteristics was the main reason for off‐label classification.
Conclusions: Paediatric off‐label drug use is common at Swedish hospitals, and nearly half of all prescriptions were not documented for use in children. The findings emphasize a need for paediatric clinical studies as well as compilation of existing clinical experience and scattered evidence, particularly for drug treatment in infants and neonates. |
| doi_str_mv | 10.1111/j.1651-2227.2012.02656.x |
| format | Article |
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Methods: All paediatric hospitals in Sweden were invited to register all prescriptions to children, aged between 0 and 18, during two separate 2‐day‐periods in 2008. Data were reported and analysed with respect to licence status and proportion of and reasons for off‐label drug use.
Results: Data on 11 294 prescriptions to 2947 paediatric patients were received. Drugs associated with pain relief, infection, prematurity, nutrition and surgery or anaesthesia were most commonly used. Paracetamol was the most frequently used drug on‐label and also among the most commonly used off‐label drugs. Nearly half (49%) of all administered prescriptions concerned unlicensed drugs, off‐label drugs or extemporaneously prepared drugs. The corresponding rate among neonates was 69%. Lack of paediatric information in the Summary of Product Characteristics was the main reason for off‐label classification.
Conclusions: Paediatric off‐label drug use is common at Swedish hospitals, and nearly half of all prescriptions were not documented for use in children. The findings emphasize a need for paediatric clinical studies as well as compilation of existing clinical experience and scattered evidence, particularly for drug treatment in infants and neonates.</description><identifier>ISSN: 0803-5253</identifier><identifier>ISSN: 1651-2227</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2012.02656.x</identifier><identifier>PMID: 22404126</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Addictive behaviors ; Adolescent ; Adult and adolescent clinical studies ; Biological and medical sciences ; Child ; Child, Preschool ; Cross-Sectional Studies ; Drug addiction ; Drug prescription ; Drug use ; Drug Utilization - statistics & numerical data ; Female ; General aspects ; Health Care Surveys ; Hospital care ; Hospitals, Pediatric - statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Miscellaneous ; Off-label ; Off-Label Use - statistics & numerical data ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Regular ; Sweden</subject><ispartof>Acta Paediatrica, 2012-07, Vol.101 (7), p.772-778</ispartof><rights>2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica</rights><rights>2015 INIST-CNRS</rights><rights>2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.</rights><rights>2012 The Author(s)/Acta Pædiatrica © 2012 Foundation Acta Pædiatrica 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6836-8a2386dfe0a3353186c2522c64068475815460351ec3e09a0128dc55b14b270c3</citedby><cites>FETCH-LOGICAL-c6836-8a2386dfe0a3353186c2522c64068475815460351ec3e09a0128dc55b14b270c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.2012.02656.x$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.2012.02656.x$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,780,784,885,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26006250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22404126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:124705062$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimland, E</creatorcontrib><creatorcontrib>Nydert, P</creatorcontrib><creatorcontrib>Odlind, V</creatorcontrib><creatorcontrib>Böttiger, Y</creatorcontrib><creatorcontrib>Lindemalm, S</creatorcontrib><title>Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim: To perform a nationwide investigation of paediatric drug use at Swedish hospitals, including an analysis of off‐label drug use.
Methods: All paediatric hospitals in Sweden were invited to register all prescriptions to children, aged between 0 and 18, during two separate 2‐day‐periods in 2008. Data were reported and analysed with respect to licence status and proportion of and reasons for off‐label drug use.
Results: Data on 11 294 prescriptions to 2947 paediatric patients were received. Drugs associated with pain relief, infection, prematurity, nutrition and surgery or anaesthesia were most commonly used. Paracetamol was the most frequently used drug on‐label and also among the most commonly used off‐label drugs. Nearly half (49%) of all administered prescriptions concerned unlicensed drugs, off‐label drugs or extemporaneously prepared drugs. The corresponding rate among neonates was 69%. Lack of paediatric information in the Summary of Product Characteristics was the main reason for off‐label classification.
Conclusions: Paediatric off‐label drug use is common at Swedish hospitals, and nearly half of all prescriptions were not documented for use in children. The findings emphasize a need for paediatric clinical studies as well as compilation of existing clinical experience and scattered evidence, particularly for drug treatment in infants and neonates.</description><subject>Addictive behaviors</subject><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Drug addiction</subject><subject>Drug prescription</subject><subject>Drug use</subject><subject>Drug Utilization - statistics & numerical data</subject><subject>Female</subject><subject>General aspects</subject><subject>Health Care Surveys</subject><subject>Hospital care</subject><subject>Hospitals, Pediatric - statistics & numerical data</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Miscellaneous</subject><subject>Off-label</subject><subject>Off-Label Use - statistics & numerical data</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Regular</subject><subject>Sweden</subject><issn>0803-5253</issn><issn>1651-2227</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkl9v0zAUxSMEYmXwFZAlhMRLiv_HfQCpmmBDHTDEEI9XruOs7tI42Altvz0O7VqGhIRfYuX-zvH19ckyRPCYpPV6OSZSkJxSWowpJnSMqRRyvHmQjQ6Fh9kIK8xyQQU7yZ7EuMSYsgmXj7MTSjnmhMpRZq60LZ3ugjOoDP0N6qNFa9ctUOVNH5FvkK-qvNZzW6M22GiCazvnm4h0h76ukzgu0MLH1nW6jihHGjV6ANautCh2fbl9mj2qUs0-239Ps2_v312fXeSXn88_nE0vcyMVk7nSlClZVhZrxgQjShoqKDWSY6l4IRQRXGImiDXM4olO91alEWJO-JwW2LDTLN_5xrVt-zm0wa102ILXDva_btPOgmBK4EniJ__k2-DLo-hOSCgvsMCSJu3bnTYBK1sa23RB1_ct7lUat4Ab_xMYZ0UySQav9gbB_-ht7GDlorF1rRvr-wgEs3QS3aEv_kKXvg9NGiWkkXBVFEzxRKkdZYKPMdjq0AzBMKQGljCEA4ZwwJAa-J0a2CTp8z8vcxDexSQBL_eAjkbXVdCNcfHISZxmIoZO3-y4tavt9r8bgOnVdNgdX9DFzm4Oeh1uQRasEPD90zlcnM1mX-T1DD6yX7Q07Qc</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Kimland, E</creator><creator>Nydert, P</creator><creator>Odlind, V</creator><creator>Böttiger, Y</creator><creator>Lindemalm, S</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>201207</creationdate><title>Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study</title><author>Kimland, E ; Nydert, P ; Odlind, V ; Böttiger, Y ; Lindemalm, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6836-8a2386dfe0a3353186c2522c64068475815460351ec3e09a0128dc55b14b270c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Addictive behaviors</topic><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Drug addiction</topic><topic>Drug prescription</topic><topic>Drug use</topic><topic>Drug Utilization - statistics & numerical data</topic><topic>Female</topic><topic>General aspects</topic><topic>Health Care Surveys</topic><topic>Hospital care</topic><topic>Hospitals, Pediatric - statistics & numerical data</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Miscellaneous</topic><topic>Off-label</topic><topic>Off-Label Use - statistics & numerical data</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Regular</topic><topic>Sweden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimland, E</creatorcontrib><creatorcontrib>Nydert, P</creatorcontrib><creatorcontrib>Odlind, V</creatorcontrib><creatorcontrib>Böttiger, Y</creatorcontrib><creatorcontrib>Lindemalm, S</creatorcontrib><collection>Istex</collection><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimland, E</au><au>Nydert, P</au><au>Odlind, V</au><au>Böttiger, Y</au><au>Lindemalm, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2012-07</date><risdate>2012</risdate><volume>101</volume><issue>7</issue><spage>772</spage><epage>778</epage><pages>772-778</pages><issn>0803-5253</issn><issn>1651-2227</issn><eissn>1651-2227</eissn><abstract>Aim: To perform a nationwide investigation of paediatric drug use at Swedish hospitals, including an analysis of off‐label drug use.
Methods: All paediatric hospitals in Sweden were invited to register all prescriptions to children, aged between 0 and 18, during two separate 2‐day‐periods in 2008. Data were reported and analysed with respect to licence status and proportion of and reasons for off‐label drug use.
Results: Data on 11 294 prescriptions to 2947 paediatric patients were received. Drugs associated with pain relief, infection, prematurity, nutrition and surgery or anaesthesia were most commonly used. Paracetamol was the most frequently used drug on‐label and also among the most commonly used off‐label drugs. Nearly half (49%) of all administered prescriptions concerned unlicensed drugs, off‐label drugs or extemporaneously prepared drugs. The corresponding rate among neonates was 69%. Lack of paediatric information in the Summary of Product Characteristics was the main reason for off‐label classification.
Conclusions: Paediatric off‐label drug use is common at Swedish hospitals, and nearly half of all prescriptions were not documented for use in children. The findings emphasize a need for paediatric clinical studies as well as compilation of existing clinical experience and scattered evidence, particularly for drug treatment in infants and neonates.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22404126</pmid><doi>10.1111/j.1651-2227.2012.02656.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SWEPUB Freely available online; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Addictive behaviors Adolescent Adult and adolescent clinical studies Biological and medical sciences Child Child, Preschool Cross-Sectional Studies Drug addiction Drug prescription Drug use Drug Utilization - statistics & numerical data Female General aspects Health Care Surveys Hospital care Hospitals, Pediatric - statistics & numerical data Humans Infant Infant, Newborn Male Medical sciences Medicin och hälsovetenskap Miscellaneous Off-label Off-Label Use - statistics & numerical data Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Regular Sweden |
| title | Paediatric drug use with focus on off-label prescriptions at Swedish hospitals - a nationwide study |
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