A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we demonstrate that RNF8, but not RNF168 or the canonical H2A ubiquitin ligase RNF2, mediates extensive chromatin decondensation....

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Veröffentlicht in:	The EMBO journal 2012-05, Vol.31 (11), p.2511-2527
Hauptverfasser:	Luijsterburg, Martijn S, Acs, Klara, Ackermann, Leena, Wiegant, Wouter W, Bekker-Jensen, Simon, Larsen, Dorthe H, Khanna, Kum Kum, van Attikum, Haico, Mailand, Niels, Dantuma, Nico P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - metabolism BRCA1 Protein - metabolism Breast cancer Cell Line, Tumor Chromatin Chromatin - metabolism Chromatin Assembly and Disassembly Cricetinae Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA damage response DNA Helicases - metabolism DNA repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DSB repair EMBO09 EMBO13 Enzymes histone ubiquitin ligase Humans Lesions Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism Mice Molecular biology RNF8 Signal transduction Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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