Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)

Rheumatoid arthritis (RA) is a multifactorial autoimmune disease in which genetic and environmental factors interact in the etiology. In this study, we investigated whether smoking and HLA-DRB1 shared-epitope (SE) alleles interact differently in the development of the two major subgroups of rheumato...

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Veröffentlicht in:	Arthritis research & therapy 2012-04, Vol.14 (2), p.R89-R89, Article R89
Hauptverfasser:	Too, Chun Lai, Yahya, Abqariyah, Murad, Shahnaz, Dhaliwal, Jasbir Singh, Larsson, Per Tobias, Muhamad, Nor Asiah, Abdullah, Nor Aini, Mustafa, Amal Nasir, Klareskog, Lars, Alfredsson, Lars, Padyukov, Leonid, Bengtsson, Camilla
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigenic determinants Arthritis Arthritis, Rheumatoid - epidemiology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - biosynthesis Case-Control Studies Citrulline - metabolism Development and progression Epitopes - immunology Epitopes - metabolism Female Genetic aspects Histocompatibility antigens HLA histocompatibility antigens HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology HLA-DRB1 Chains - metabolism Humans Investigations Malaysia - epidemiology Male Medicin och hälsovetenskap Middle Aged Physiological aspects Proteins Rheumatoid factor Risk factors Smoking Smoking - epidemiology Smoking - genetics Smoking - immunology
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