Parental Age, Family Size, and Offspring's Risk of Childhood and Adult Acute Leukemia
An association between childhood acute leukemia and advanced parental age was observed more than 50 years ago, and the association has been repeated in several, but not all, subsequent studies. In contrast to the many studies addressing childhood leukemia, few have included adult patients. In this r...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2012-07, Vol.21 (7), p.1185-1190 |
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| creator | LARFORS, Gunnar HALLBÖÖK, Helene SIMONSSON, Bengt |
| description | An association between childhood acute leukemia and advanced parental age was observed more than 50 years ago, and the association has been repeated in several, but not all, subsequent studies. In contrast to the many studies addressing childhood leukemia, few have included adult patients.
In this register-based case-control study, we examined the association between parental age and incidence of acute leukemia in 2,660 childhood cases and 4,412 adult cases of acute leukemia, compared with 28,288 age-matched controls selected from a population-based register. Relative risks were estimated with conditional logistic regression.
We found a small increased risk of childhood acute lymphoblastic leukemia with increasing paternal age (adjusted OR, 1.05 per 5-year increase in age). Risk estimates were similar for childhood acute myeloid leukemia (AML), whereas no association was found with adult leukemia. Meanwhile, we observed a decreased risk of adult AML with increasing number of siblings, both older and younger.
The results support the idea of a prenatal etiology of leukemia but indicate that parental age effects are limited to childhood cases.
This is the first large study on parental age and leukemia risk, which includes adult cases. The finding on family size and risk of adult AML needs to be validated in future studies. |
| doi_str_mv | 10.1158/1055-9965.EPI-12-0178 |
| format | Article |
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In this register-based case-control study, we examined the association between parental age and incidence of acute leukemia in 2,660 childhood cases and 4,412 adult cases of acute leukemia, compared with 28,288 age-matched controls selected from a population-based register. Relative risks were estimated with conditional logistic regression.
We found a small increased risk of childhood acute lymphoblastic leukemia with increasing paternal age (adjusted OR, 1.05 per 5-year increase in age). Risk estimates were similar for childhood acute myeloid leukemia (AML), whereas no association was found with adult leukemia. Meanwhile, we observed a decreased risk of adult AML with increasing number of siblings, both older and younger.
The results support the idea of a prenatal etiology of leukemia but indicate that parental age effects are limited to childhood cases.
This is the first large study on parental age and leukemia risk, which includes adult cases. The finding on family size and risk of adult AML needs to be validated in future studies.</description><identifier>ISSN: 1055-9965</identifier><identifier>ISSN: 1538-7755</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-12-0178</identifier><identifier>PMID: 22539609</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Case-Control Studies ; Down Syndrome - complications ; Down Syndrome - epidemiology ; Family Characteristics ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Myeloid, Acute - epidemiology ; Leukemia, Myeloid, Acute - etiology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Parents ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prognosis ; Registries ; Risk Factors ; Sweden - epidemiology ; Tumors ; Young Adult</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2012-07, Vol.21 (7), p.1185-1190</ispartof><rights>2015 INIST-CNRS</rights><rights>2012 AACR</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-4eab84066b7b9103d83d3b68148680e1a1bf7ee36cb36307a9e0f667833792cd3</citedby><cites>FETCH-LOGICAL-c414t-4eab84066b7b9103d83d3b68148680e1a1bf7ee36cb36307a9e0f667833792cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26098745$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22539609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179032$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:124905103$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>LARFORS, Gunnar</creatorcontrib><creatorcontrib>HALLBÖÖK, Helene</creatorcontrib><creatorcontrib>SIMONSSON, Bengt</creatorcontrib><title>Parental Age, Family Size, and Offspring's Risk of Childhood and Adult Acute Leukemia</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>An association between childhood acute leukemia and advanced parental age was observed more than 50 years ago, and the association has been repeated in several, but not all, subsequent studies. In contrast to the many studies addressing childhood leukemia, few have included adult patients.
In this register-based case-control study, we examined the association between parental age and incidence of acute leukemia in 2,660 childhood cases and 4,412 adult cases of acute leukemia, compared with 28,288 age-matched controls selected from a population-based register. Relative risks were estimated with conditional logistic regression.
We found a small increased risk of childhood acute lymphoblastic leukemia with increasing paternal age (adjusted OR, 1.05 per 5-year increase in age). Risk estimates were similar for childhood acute myeloid leukemia (AML), whereas no association was found with adult leukemia. Meanwhile, we observed a decreased risk of adult AML with increasing number of siblings, both older and younger.
The results support the idea of a prenatal etiology of leukemia but indicate that parental age effects are limited to childhood cases.
This is the first large study on parental age and leukemia risk, which includes adult cases. The finding on family size and risk of adult AML needs to be validated in future studies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Down Syndrome - complications</subject><subject>Down Syndrome - epidemiology</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - epidemiology</subject><subject>Leukemia, Myeloid, Acute - etiology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parents</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prognosis</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Sweden - epidemiology</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1055-9965</issn><issn>1538-7755</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UtP3DAQB3CrasX7I7TypSoHAnb8PkbLo0grgaD0ajnJZHE3j20cC9FPXy-7wImTx9ZvZiz9EfpKySmlQp9RIkRmjBSnF7fXGc0zQpX-hPaoYDpTSojPqX41u2g_hD-EEGWE2EG7eS6YkcTsoYdbN0I_uRYXCzjBl67z7TO-9__SxfU1vmmasBp9v_gR8J0PSzw0ePbo2_pxGOoXUdSxnXBRxQnwHOISOu8O0ZfGtQGOtucBeri8-DX7mc1vrq5nxTyrOOVTxsGVmhMpS1UaSlitWc1KqSnXUhOgjpaNAmCyKplkRDkDpJFSacaUyauaHaBsMzc8wSqWNv20c-OzHZy326dlqsAKprghyZ986M_978IO48LGaKlKOE_8eMNX4_A3Qphs50MFbet6GGKwlOSccUO1SlRsaDUOIYzQvM2mxK4Ds-sw7DoMmwKzNLfrwFLft-2KWHZQv3W9JpTA9y1woXJtM7q-8uHdJaMVF-w_Udycpg</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>LARFORS, Gunnar</creator><creator>HALLBÖÖK, Helene</creator><creator>SIMONSSON, Bengt</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>20120701</creationdate><title>Parental Age, Family Size, and Offspring's Risk of Childhood and Adult Acute Leukemia</title><author>LARFORS, Gunnar ; HALLBÖÖK, Helene ; SIMONSSON, Bengt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-4eab84066b7b9103d83d3b68148680e1a1bf7ee36cb36307a9e0f667833792cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Down Syndrome - complications</topic><topic>Down Syndrome - epidemiology</topic><topic>Family Characteristics</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - epidemiology</topic><topic>Leukemia, Myeloid, Acute - etiology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parents</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prognosis</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Sweden - epidemiology</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LARFORS, Gunnar</creatorcontrib><creatorcontrib>HALLBÖÖK, Helene</creatorcontrib><creatorcontrib>SIMONSSON, Bengt</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LARFORS, Gunnar</au><au>HALLBÖÖK, Helene</au><au>SIMONSSON, Bengt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parental Age, Family Size, and Offspring's Risk of Childhood and Adult Acute Leukemia</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>21</volume><issue>7</issue><spage>1185</spage><epage>1190</epage><pages>1185-1190</pages><issn>1055-9965</issn><issn>1538-7755</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>An association between childhood acute leukemia and advanced parental age was observed more than 50 years ago, and the association has been repeated in several, but not all, subsequent studies. In contrast to the many studies addressing childhood leukemia, few have included adult patients.
In this register-based case-control study, we examined the association between parental age and incidence of acute leukemia in 2,660 childhood cases and 4,412 adult cases of acute leukemia, compared with 28,288 age-matched controls selected from a population-based register. Relative risks were estimated with conditional logistic regression.
We found a small increased risk of childhood acute lymphoblastic leukemia with increasing paternal age (adjusted OR, 1.05 per 5-year increase in age). Risk estimates were similar for childhood acute myeloid leukemia (AML), whereas no association was found with adult leukemia. Meanwhile, we observed a decreased risk of adult AML with increasing number of siblings, both older and younger.
The results support the idea of a prenatal etiology of leukemia but indicate that parental age effects are limited to childhood cases.
This is the first large study on parental age and leukemia risk, which includes adult cases. The finding on family size and risk of adult AML needs to be validated in future studies.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>22539609</pmid><doi>10.1158/1055-9965.EPI-12-0178</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Case-Control Studies Down Syndrome - complications Down Syndrome - epidemiology Family Characteristics Female Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - epidemiology Leukemia, Myeloid, Acute - etiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Parents Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology Pregnancy Prenatal Exposure Delayed Effects Prognosis Registries Risk Factors Sweden - epidemiology Tumors Young Adult |
| title | Parental Age, Family Size, and Offspring's Risk of Childhood and Adult Acute Leukemia |
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