An allosteric modulator of metabotropic glutamate receptors (mGluR2), (+)-TFMPIP, inhibits restraint stress-induced phasic glutamate release in rat prefrontal cortex

J. Neurochem. (2012) 122, 619–627. The potential anxiolytic effects of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor subgroup 2 (mGluR2) were investigated using a self‐referencing recording technique with enzyme‐based microelectrode arrays (MEAs) that reliably me...

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Veröffentlicht in:	Journal of neurochemistry 2012-08, Vol.122 (3), p.619-627
Hauptverfasser:	Hascup, Erin R., Hascup, Kevin N., Pomerleau, Francois, Huettl, Peter, Hajos-Korcsok, Eva, Kehr, Jan, Gerhardt, Greg A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Allosteric Regulation amperometry Animals Anxiety anxiolytic Anxiolytics Biological and medical sciences biosensor Body Weight - drug effects Body Weight - physiology Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cortex (prefrontal) Data processing Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzymes Excitatory Amino Acid Agonists - pharmacology Fundamental and applied biological sciences. Psychology gamma -Aminobutyric acid Glutamic acid Glutamic Acid - metabolism Glutamic acid receptors Glutamic acid receptors (metabotropic) Male Medical sciences Medicin och hälsovetenskap Microelectrodes monoamines mood disorder Neurochemistry Neurology Neuromodulation Neurons neurotransmitter Neurotransmitters Piperidines - pharmacology Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - agonists Restraint, Physical - methods Restraint, Physical - physiology Rodents Side effects Stress therapeutic targets Vertebrates: nervous system and sense organs Wakefulness
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