Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury

Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans. We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in adult mice. The present studies tested the hypothesis that TrxR1 inhibition protects a...

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Veröffentlicht in:	ANTIOXIDANTS & REDOX SIGNALING 2012-11, Vol.17 (10), p.1407-1416
Hauptverfasser:	Locy, Morgan L, Rogers, Lynette K, Prigge, Justin R, Schmidt, Edward E, Arnér, Elias S J, Tipple, Trent E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurothioglucose - pharmacology Humans Lung Injury - metabolism Mice NAD(P)H Dehydrogenase (Quinone) - metabolism NF-E2-Related Factor 2 - metabolism Original Research Communications Oxidants - toxicity Thioredoxin-Disulfide Reductase - antagonists & inhibitors Thioredoxin-Disulfide Reductase - metabolism
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