MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis

MMP14 encodes a membrane-tethered metalloproteinase MT1-MMP, capable of remodeling the extracellular matrix and modulating receptors on the cell surface. Loss of MT1-MMP results in craniofacial abnormalities. Here we show that MT1-MMP forms a complex with FGFR2 and ADAM9 in osteoblasts and proteolyt...

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Veröffentlicht in:	Developmental cell 2012-06, Vol.22 (6), p.1176-1190
Hauptverfasser:	Chan, Kui Ming, Wong, Hoi Leong Xavier, Jin, Guoxiang, Liu, Baohua, Cao, Renhai, Cao, Yihai, Lehti, Kaisa, Tryggvason, Karl, Zhou, Zhongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM Proteins - physiology Animals Biological and medical sciences Bone growth Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell surface Cells, Cultured Data processing Embryos Extracellular matrix Fibroblast growth factor receptor 2 Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 14 - physiology Membrane Proteins - metabolism Membrane Proteins - physiology Mice Molecular and cellular biology Osteoblasts Osteoblasts - metabolism Osteoblasts - physiology Osteogenesis Osteogenesis - physiology Receptor, Fibroblast Growth Factor, Type 2 - metabolism Receptor, Fibroblast Growth Factor, Type 2 - physiology Signal Transduction - physiology Skull - metabolism Skull - physiology
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