Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease
Abstract Background Patients with cyanotic congenital heart disease (CCHD) have haemostatic abnormities associated with bleeding and thrombo-embolic events. The haemostatic abnormalities are not fully understood, but recent studies indicate that elevated haematocrit and fibrinogen function may be of...
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| Veröffentlicht in: | International journal of cardiology 2013-09, Vol.167 (5), p.2210-2214 |
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| creator | Jensen, A.S Johansson, P.I Bochsen, L Idorn, L Sørensen, K.E Thilén, U Nagy, E Furenäs, E Søndergaard, L |
| description | Abstract Background Patients with cyanotic congenital heart disease (CCHD) have haemostatic abnormities associated with bleeding and thrombo-embolic events. The haemostatic abnormalities are not fully understood, but recent studies indicate that elevated haematocrit and fibrinogen function may be of importance. The aim of this study was to characterise the haemostatic profile and examine the potential role of haematocrit on clot formation and strength in CCHD patients. Furthermore to examine whether CCHD patients with history of haemoptysis have diminished fibrinogen function compared to those without haemoptysis. Methods In a prospective study 75 adult CCHD patients had haematocrit, platelet count, and plasma fibrinogen concentration examined. Furthermore thrombelastography(TEG) as well as TEG Functional Fibrinogen(TEG FF) assay evaluating fibrinogen function(FLEV) was performed. Data were compared with historical data regarding previous haemoptysis in CCHD patients. Results Haematocrit was 57 ± 8% and platelet counts in the lower normal range. TEG revealed a hypocoagulable condition with impaired clot formation. TEG values were correlated to haematocrit, indicating that elevated haematocrit causes impaired clot formation and strength. Despite high levels of plasma fibrinogen, TEG FF demonstrated that FLEV was diminished and negatively correlated to haematocrit. Furthermore CCHD patients with previous history of haemoptysis had significantly lower FLEV compared to CCHD patients without haemoptysis. Conclusion Patients with CCHD are hypocoagulable mainly due to impaired fibrinogen function. Despite a low platelet count, platelet function does not seem to be severely affected in CCHD patients. Haemostasis, and especially fibrinogen function, is negatively affected by elevated haematocrit, and fibrinogen function is diminished in CCHD patients with haemoptysis. |
| doi_str_mv | 10.1016/j.ijcard.2012.06.019 |
| format | Article |
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The haemostatic abnormalities are not fully understood, but recent studies indicate that elevated haematocrit and fibrinogen function may be of importance. The aim of this study was to characterise the haemostatic profile and examine the potential role of haematocrit on clot formation and strength in CCHD patients. Furthermore to examine whether CCHD patients with history of haemoptysis have diminished fibrinogen function compared to those without haemoptysis. Methods In a prospective study 75 adult CCHD patients had haematocrit, platelet count, and plasma fibrinogen concentration examined. Furthermore thrombelastography(TEG) as well as TEG Functional Fibrinogen(TEG FF) assay evaluating fibrinogen function(FLEV) was performed. Data were compared with historical data regarding previous haemoptysis in CCHD patients. Results Haematocrit was 57 ± 8% and platelet counts in the lower normal range. TEG revealed a hypocoagulable condition with impaired clot formation. TEG values were correlated to haematocrit, indicating that elevated haematocrit causes impaired clot formation and strength. Despite high levels of plasma fibrinogen, TEG FF demonstrated that FLEV was diminished and negatively correlated to haematocrit. Furthermore CCHD patients with previous history of haemoptysis had significantly lower FLEV compared to CCHD patients without haemoptysis. Conclusion Patients with CCHD are hypocoagulable mainly due to impaired fibrinogen function. Despite a low platelet count, platelet function does not seem to be severely affected in CCHD patients. Haemostasis, and especially fibrinogen function, is negatively affected by elevated haematocrit, and fibrinogen function is diminished in CCHD patients with haemoptysis.</description><identifier>ISSN: 0167-5273</identifier><identifier>ISSN: 1874-1754</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2012.06.019</identifier><identifier>PMID: 22727966</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cardiac and Cardiovascular Systems ; Cardiology. Vascular system ; Cardiopathies: etiologic forms (general aspects and miscellaneous) ; Cardiovascular ; Clinical Medicine ; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava ; Cyanosis ; Cyanotic congenital heart disease ; Female ; Fibrinogen - physiology ; Functional fibrinogen ; Fysiologi ; Haematocrit ; Haemoptysis ; Heart ; Heart Defects, Congenital - blood ; Heart Defects, Congenital - diagnosis ; Hemostasis - physiology ; Humans ; Kardiologi ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Medicinska och farmaceutiska grundvetenskaper ; Middle Aged ; Platelet Count - methods ; Pneumology ; Prospective Studies ; Respiratory system : syndromes and miscellaneous diseases ; Thrombelastography ; Thrombelastography - methods ; Whole Blood Coagulation Time - methods</subject><ispartof>International journal of cardiology, 2013-09, Vol.167 (5), p.2210-2214</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-ef2734223cdbd1998f8a5b97a75da48ff945c79bb8b7c9efec6fdf5c0b33828e3</citedby><cites>FETCH-LOGICAL-c604t-ef2734223cdbd1998f8a5b97a75da48ff945c79bb8b7c9efec6fdf5c0b33828e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2012.06.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27702391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22727966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/4062818$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:127281315$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, A.S</creatorcontrib><creatorcontrib>Johansson, P.I</creatorcontrib><creatorcontrib>Bochsen, L</creatorcontrib><creatorcontrib>Idorn, L</creatorcontrib><creatorcontrib>Sørensen, K.E</creatorcontrib><creatorcontrib>Thilén, U</creatorcontrib><creatorcontrib>Nagy, E</creatorcontrib><creatorcontrib>Furenäs, E</creatorcontrib><creatorcontrib>Søndergaard, L</creatorcontrib><title>Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Abstract Background Patients with cyanotic congenital heart disease (CCHD) have haemostatic abnormities associated with bleeding and thrombo-embolic events. The haemostatic abnormalities are not fully understood, but recent studies indicate that elevated haematocrit and fibrinogen function may be of importance. The aim of this study was to characterise the haemostatic profile and examine the potential role of haematocrit on clot formation and strength in CCHD patients. Furthermore to examine whether CCHD patients with history of haemoptysis have diminished fibrinogen function compared to those without haemoptysis. Methods In a prospective study 75 adult CCHD patients had haematocrit, platelet count, and plasma fibrinogen concentration examined. Furthermore thrombelastography(TEG) as well as TEG Functional Fibrinogen(TEG FF) assay evaluating fibrinogen function(FLEV) was performed. Data were compared with historical data regarding previous haemoptysis in CCHD patients. Results Haematocrit was 57 ± 8% and platelet counts in the lower normal range. TEG revealed a hypocoagulable condition with impaired clot formation. TEG values were correlated to haematocrit, indicating that elevated haematocrit causes impaired clot formation and strength. Despite high levels of plasma fibrinogen, TEG FF demonstrated that FLEV was diminished and negatively correlated to haematocrit. Furthermore CCHD patients with previous history of haemoptysis had significantly lower FLEV compared to CCHD patients without haemoptysis. Conclusion Patients with CCHD are hypocoagulable mainly due to impaired fibrinogen function. Despite a low platelet count, platelet function does not seem to be severely affected in CCHD patients. Haemostasis, and especially fibrinogen function, is negatively affected by elevated haematocrit, and fibrinogen function is diminished in CCHD patients with haemoptysis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiac and Cardiovascular Systems</subject><subject>Cardiology. Vascular system</subject><subject>Cardiopathies: etiologic forms (general aspects and miscellaneous)</subject><subject>Cardiovascular</subject><subject>Clinical Medicine</subject><subject>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</subject><subject>Cyanosis</subject><subject>Cyanotic congenital heart disease</subject><subject>Female</subject><subject>Fibrinogen - physiology</subject><subject>Functional fibrinogen</subject><subject>Fysiologi</subject><subject>Haematocrit</subject><subject>Haemoptysis</subject><subject>Heart</subject><subject>Heart Defects, Congenital - blood</subject><subject>Heart Defects, Congenital - diagnosis</subject><subject>Hemostasis - physiology</subject><subject>Humans</subject><subject>Kardiologi</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicinska och farmaceutiska grundvetenskaper</subject><subject>Middle Aged</subject><subject>Platelet Count - methods</subject><subject>Pneumology</subject><subject>Prospective Studies</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Thrombelastography</subject><subject>Thrombelastography - methods</subject><subject>Whole Blood Coagulation Time - methods</subject><issn>0167-5273</issn><issn>1874-1754</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoso7rr6D0RyI3jTMUnTJrkRZHFVGPBCvQ75OHEy20nGpHWYf2-Gzu6CsHgRWsrzvueQPk3zmuAVwWR4v12FrdXZrSgmdIWHFSbySXNJBGct4T172lxWjLc95d1F86KULcaYSSmeNxeUcsrlMFw29iaYHGL6BRH5OdoppIhCQWG31yGDQyGiwyaNgMyYkkM-px3a6ylAnAo6hGmD7FHHNAWLbIq1Jkx6RBvQeUIuFNAFXjbPvB4LvDo_r5qfN59-XH9p198-f73-uG7tgNnUgq-bMko764wjdVEvdG8k17x3mgnvJestl8YIw60ED3bwzvcWm64TVEB31bRLbznAfjZqn8NO56NKOqjzp9v6Bqrvho70lZeP8vuc3EPoLkjqvQmyZNePZsd5X4-p55QRHRuw4E5Rj7liBDNlhNaKDl4w4wzmRNe6d0tdnft7hjKpXSgWxlFHSHNRhFE51MsRsqJsQW1OpWTw97MJVicz1FYtZqiTGQoPqppRY2_OE2azA3cfulOhAm_PgC5Wjz7raEN54DjHtJOkch8WDuqv_BMgq2KrDRZc9cVOyqXwv03-LbBjiKHOvIUjlG2ac6yaKKJKzajvJ4tPEhOKMZeMdn8Bd6zwPw</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Jensen, A.S</creator><creator>Johansson, P.I</creator><creator>Bochsen, L</creator><creator>Idorn, L</creator><creator>Sørensen, K.E</creator><creator>Thilén, U</creator><creator>Nagy, E</creator><creator>Furenäs, E</creator><creator>Søndergaard, L</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D95</scope></search><sort><creationdate>20130901</creationdate><title>Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease</title><author>Jensen, A.S ; Johansson, P.I ; Bochsen, L ; Idorn, L ; Sørensen, K.E ; Thilén, U ; Nagy, E ; Furenäs, E ; Søndergaard, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-ef2734223cdbd1998f8a5b97a75da48ff945c79bb8b7c9efec6fdf5c0b33828e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiac and Cardiovascular Systems</topic><topic>Cardiology. Vascular system</topic><topic>Cardiopathies: etiologic forms (general aspects and miscellaneous)</topic><topic>Cardiovascular</topic><topic>Clinical Medicine</topic><topic>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</topic><topic>Cyanosis</topic><topic>Cyanotic congenital heart disease</topic><topic>Female</topic><topic>Fibrinogen - physiology</topic><topic>Functional fibrinogen</topic><topic>Fysiologi</topic><topic>Haematocrit</topic><topic>Haemoptysis</topic><topic>Heart</topic><topic>Heart Defects, Congenital - blood</topic><topic>Heart Defects, Congenital - diagnosis</topic><topic>Hemostasis - physiology</topic><topic>Humans</topic><topic>Kardiologi</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicinska och farmaceutiska grundvetenskaper</topic><topic>Middle Aged</topic><topic>Platelet Count - methods</topic><topic>Pneumology</topic><topic>Prospective Studies</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Thrombelastography</topic><topic>Thrombelastography - methods</topic><topic>Whole Blood Coagulation Time - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, A.S</creatorcontrib><creatorcontrib>Johansson, P.I</creatorcontrib><creatorcontrib>Bochsen, L</creatorcontrib><creatorcontrib>Idorn, L</creatorcontrib><creatorcontrib>Sørensen, K.E</creatorcontrib><creatorcontrib>Thilén, U</creatorcontrib><creatorcontrib>Nagy, E</creatorcontrib><creatorcontrib>Furenäs, E</creatorcontrib><creatorcontrib>Søndergaard, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Lunds universitet</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, A.S</au><au>Johansson, P.I</au><au>Bochsen, L</au><au>Idorn, L</au><au>Sørensen, K.E</au><au>Thilén, U</au><au>Nagy, E</au><au>Furenäs, E</au><au>Søndergaard, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>167</volume><issue>5</issue><spage>2210</spage><epage>2214</epage><pages>2210-2214</pages><issn>0167-5273</issn><issn>1874-1754</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Abstract Background Patients with cyanotic congenital heart disease (CCHD) have haemostatic abnormities associated with bleeding and thrombo-embolic events. The haemostatic abnormalities are not fully understood, but recent studies indicate that elevated haematocrit and fibrinogen function may be of importance. The aim of this study was to characterise the haemostatic profile and examine the potential role of haematocrit on clot formation and strength in CCHD patients. Furthermore to examine whether CCHD patients with history of haemoptysis have diminished fibrinogen function compared to those without haemoptysis. Methods In a prospective study 75 adult CCHD patients had haematocrit, platelet count, and plasma fibrinogen concentration examined. Furthermore thrombelastography(TEG) as well as TEG Functional Fibrinogen(TEG FF) assay evaluating fibrinogen function(FLEV) was performed. Data were compared with historical data regarding previous haemoptysis in CCHD patients. Results Haematocrit was 57 ± 8% and platelet counts in the lower normal range. TEG revealed a hypocoagulable condition with impaired clot formation. TEG values were correlated to haematocrit, indicating that elevated haematocrit causes impaired clot formation and strength. Despite high levels of plasma fibrinogen, TEG FF demonstrated that FLEV was diminished and negatively correlated to haematocrit. Furthermore CCHD patients with previous history of haemoptysis had significantly lower FLEV compared to CCHD patients without haemoptysis. Conclusion Patients with CCHD are hypocoagulable mainly due to impaired fibrinogen function. Despite a low platelet count, platelet function does not seem to be severely affected in CCHD patients. Haemostasis, and especially fibrinogen function, is negatively affected by elevated haematocrit, and fibrinogen function is diminished in CCHD patients with haemoptysis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>22727966</pmid><doi>10.1016/j.ijcard.2012.06.019</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cardiac and Cardiovascular Systems Cardiology. Vascular system Cardiopathies: etiologic forms (general aspects and miscellaneous) Cardiovascular Clinical Medicine Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava Cyanosis Cyanotic congenital heart disease Female Fibrinogen - physiology Functional fibrinogen Fysiologi Haematocrit Haemoptysis Heart Heart Defects, Congenital - blood Heart Defects, Congenital - diagnosis Hemostasis - physiology Humans Kardiologi Klinisk medicin Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Middle Aged Platelet Count - methods Pneumology Prospective Studies Respiratory system : syndromes and miscellaneous diseases Thrombelastography Thrombelastography - methods Whole Blood Coagulation Time - methods |
| title | Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease |
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