Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production

Erlin-2 and γ-secretase interact (red dots) in BD3 cells. [Display omitted] ► We find erlin-2 to be associated with active γ-secretase in brain tissue. ► We visualize this interaction in cells by using a proximity ligation assay. ► Silencing of erlin-2 expression results in reduced Aβ, but not NICD,...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-08, Vol.424 (3), p.476-481
Hauptverfasser:	Teranishi, Yasuhiro, Hur, Ji-Yeun, Gu, Gucci Jijuan, Kihara, Takahiro, Ishikawa, Taizo, Nishimura, Takeshi, Winblad, Bengt, Behbahani, Homira, Kamali-Moghaddam, Masood, Frykman, Susanne, Tjernberg, Lars O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity purification Alzheimer disease Alzheimer Disease - metabolism Amyloid beta-Peptides - biosynthesis Amyloid Precursor Protein Secretases - metabolism Amyloid β-peptide Animals Brain - metabolism Detergent resistant membranes Erlin-2 Humans Medicin och hälsovetenskap Membrane Proteins - genetics Membrane Proteins - metabolism Mice Rats Rats, Sprague-Dawley RNA, Small Interfering - genetics γ-Secretase
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