Hepatocyte transplantation for inherited metabolic diseases of the liver
Inherited metabolic diseases of the liver are characterized by deficiency of a hepatic enzyme or protein often resulting in life‐threatening disease. The remaining liver function is usually normal. For most patients, treatment consists of supportive therapy, and the only curative option is liver tra...
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| Veröffentlicht in: | Journal of internal medicine 2012-09, Vol.272 (3), p.201-223 |
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| container_title | Journal of internal medicine |
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| creator | Jorns, C. Ellis, E. C. Nowak, G. Fischler, B. Nemeth, A. Strom, S. C. Ericzon, B. G. |
| description | Inherited metabolic diseases of the liver are characterized by deficiency of a hepatic enzyme or protein often resulting in life‐threatening disease. The remaining liver function is usually normal. For most patients, treatment consists of supportive therapy, and the only curative option is liver transplantation. Hepatocyte transplantation is a promising therapy for patients with inherited metabolic liver diseases, which offers a less invasive and fully reversible approach. Procedure‐related complications are rare. Here, we review the experience of hepatocyte transplantation for metabolic liver diseases and discuss the major obstacles that need to be overcome to establish hepatocyte transplantation as a reliable treatment option in the clinic. |
| doi_str_mv | 10.1111/j.1365-2796.2012.02574.x |
| format | Article |
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| subjects | Adaptive Immunity Animals Biological and medical sciences Cell Culture Techniques Cell Transplantation - methods Cellular Senescence Cryopreservation experimental General aspects Hepatocytes - cytology hepatology Humans Immunity, Innate Immunosuppression liver Liver Diseases - therapy Medical sciences Metabolism, Inborn Errors - therapy surgery Tissue Donors Transplantation Conditioning transplantation immunology α-1-antitrypsin deficiency |
| title | Hepatocyte transplantation for inherited metabolic diseases of the liver |
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