Retrospective Multicenter Study of Solitaire FR for Revascularization in the Treatment of Acute Ischemic Stroke
The purpose of this study was to evaluate safety and efficacy of the Solitaire FR device in the treatment of patients with acute ischemic stroke secondary to large artery occlusion. We conducted a retrospective study of consecutive patients presenting with acute ischemic stroke treated with Solitair...
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| Veröffentlicht in: | Stroke (1970) 2012-10, Vol.43 (10), p.2699-2705 |
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| creator | Dávalos, Antoni Pereira, Vitor Mendes Chapot, René Bonafé, Alain Andersson, Tommy Gralla, Jan |
| description | The purpose of this study was to evaluate safety and efficacy of the Solitaire FR device in the treatment of patients with acute ischemic stroke secondary to large artery occlusion.
We conducted a retrospective study of consecutive patients presenting with acute ischemic stroke treated with Solitaire FR as the first-line device to restore blood flow in 6 experienced European centers. This study was entirely funded and supported by Coviden Neurovascular. An independent Corelab determined modified Thrombolysis in Cerebral Infarction scores on the preprocedure and postprocedure angiograms. Complete revascularization was defined as modified Thrombolysis in Cerebral Infarction 2b or 3 post-Solitaire FR device use. Symptomatic intracranial hemorrhage was defined as parenchymal hemorrhage Type 2 associated with a decline of ≥ 4 points in the National Institutes of Health Stroke Scale score within 24 hours or causing death. Favorable functional outcome was considered as modified Rankin Scale score ≤ 2 at Day 90.
We studied 141 patients (mean age, 66 years; median National Institutes of Health Stroke Scale, 18); 74 patients received intravenous tissue-type plasminogen activator before endovascular treatment. Complete revascularization was achieved in 120 of 142 occlusion sites (85%) and good outcome in 77 of 141 (55%) patients. Good outcome was more frequent in patients treated with intravenous tissue-type plasminogen activator than in those without (66% versus 42%; P |
| doi_str_mv | 10.1161/STROKEAHA.112.663328 |
| format | Article |
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We conducted a retrospective study of consecutive patients presenting with acute ischemic stroke treated with Solitaire FR as the first-line device to restore blood flow in 6 experienced European centers. This study was entirely funded and supported by Coviden Neurovascular. An independent Corelab determined modified Thrombolysis in Cerebral Infarction scores on the preprocedure and postprocedure angiograms. Complete revascularization was defined as modified Thrombolysis in Cerebral Infarction 2b or 3 post-Solitaire FR device use. Symptomatic intracranial hemorrhage was defined as parenchymal hemorrhage Type 2 associated with a decline of ≥ 4 points in the National Institutes of Health Stroke Scale score within 24 hours or causing death. Favorable functional outcome was considered as modified Rankin Scale score ≤ 2 at Day 90.
We studied 141 patients (mean age, 66 years; median National Institutes of Health Stroke Scale, 18); 74 patients received intravenous tissue-type plasminogen activator before endovascular treatment. Complete revascularization was achieved in 120 of 142 occlusion sites (85%) and good outcome in 77 of 141 (55%) patients. Good outcome was more frequent in patients treated with intravenous tissue-type plasminogen activator than in those without (66% versus 42%; P<0.01). Symptomatic intracranial hemorrhage was reported in 5 patients (4%) and 29 of 141 (20%) patients died or were lost during follow-up (3 cases).
This retrospective study with centralized evaluation shows that the use of Solitaire FR is safe and achieves good revascularization rates and functional outcomes in patients with acute ischemic stroke and large artery occlusion.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.112.663328</identifier><identifier>PMID: 22851547</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Brain - blood supply ; Cardiovascular system ; Cerebral Revascularization - instrumentation ; Cerebral Revascularization - methods ; Cerebrovascular Disorders - drug therapy ; Equipment and Supplies - adverse effects ; Europe ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Pharmacology. Drug treatments ; Regional Blood Flow - physiology ; Retrospective Studies ; Stents - adverse effects ; Stroke - physiopathology ; Stroke - therapy ; Thrombectomy - instrumentation ; Thrombolytic Therapy - methods ; Tissue Plasminogen Activator - therapeutic use ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>Stroke (1970), 2012-10, Vol.43 (10), p.2699-2705</ispartof><rights>American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5329-28879f8f26a7d4c9fbb5658b855f7a1a8f9edfc8f17adeeea241dd1692168f863</citedby><cites>FETCH-LOGICAL-c5329-28879f8f26a7d4c9fbb5658b855f7a1a8f9edfc8f17adeeea241dd1692168f863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26403156$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22851547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:125357938$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Dávalos, Antoni</creatorcontrib><creatorcontrib>Pereira, Vitor Mendes</creatorcontrib><creatorcontrib>Chapot, René</creatorcontrib><creatorcontrib>Bonafé, Alain</creatorcontrib><creatorcontrib>Andersson, Tommy</creatorcontrib><creatorcontrib>Gralla, Jan</creatorcontrib><creatorcontrib>Solitaire Group</creatorcontrib><title>Retrospective Multicenter Study of Solitaire FR for Revascularization in the Treatment of Acute Ischemic Stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>The purpose of this study was to evaluate safety and efficacy of the Solitaire FR device in the treatment of patients with acute ischemic stroke secondary to large artery occlusion.
We conducted a retrospective study of consecutive patients presenting with acute ischemic stroke treated with Solitaire FR as the first-line device to restore blood flow in 6 experienced European centers. This study was entirely funded and supported by Coviden Neurovascular. An independent Corelab determined modified Thrombolysis in Cerebral Infarction scores on the preprocedure and postprocedure angiograms. Complete revascularization was defined as modified Thrombolysis in Cerebral Infarction 2b or 3 post-Solitaire FR device use. Symptomatic intracranial hemorrhage was defined as parenchymal hemorrhage Type 2 associated with a decline of ≥ 4 points in the National Institutes of Health Stroke Scale score within 24 hours or causing death. Favorable functional outcome was considered as modified Rankin Scale score ≤ 2 at Day 90.
We studied 141 patients (mean age, 66 years; median National Institutes of Health Stroke Scale, 18); 74 patients received intravenous tissue-type plasminogen activator before endovascular treatment. Complete revascularization was achieved in 120 of 142 occlusion sites (85%) and good outcome in 77 of 141 (55%) patients. Good outcome was more frequent in patients treated with intravenous tissue-type plasminogen activator than in those without (66% versus 42%; P<0.01). Symptomatic intracranial hemorrhage was reported in 5 patients (4%) and 29 of 141 (20%) patients died or were lost during follow-up (3 cases).
This retrospective study with centralized evaluation shows that the use of Solitaire FR is safe and achieves good revascularization rates and functional outcomes in patients with acute ischemic stroke and large artery occlusion.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Cardiovascular system</subject><subject>Cerebral Revascularization - instrumentation</subject><subject>Cerebral Revascularization - methods</subject><subject>Cerebrovascular Disorders - drug therapy</subject><subject>Equipment and Supplies - adverse effects</subject><subject>Europe</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Pharmacology. Drug treatments</subject><subject>Regional Blood Flow - physiology</subject><subject>Retrospective Studies</subject><subject>Stents - adverse effects</subject><subject>Stroke - physiopathology</subject><subject>Stroke - therapy</subject><subject>Thrombectomy - instrumentation</subject><subject>Thrombolytic Therapy - methods</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpFkdFu2yAUhq1p05p1e4Np4mZSb9wBNhhfRlW7VutUKcmuEcYHhQWbDHCj7umHlSy9goO-_xx0vqL4TPA1IZx8W29WTz9ul_fLXNJrzquKijfFgjBalzWn4m2xwLhqS1q37UXxIcbfGGNaCfa-uKBUMMLqZlH4FaTg4x50ss-Afk4uWQ1jgoDWaepfkDdo7Z1NygZAdytkfEAreFZRT04F-1cl60dkR5S2gDYBVBpyfI4t9ZQAPUS9hcHq3C74HXws3hnlInw6nZfFr7vbzc19-fj0_eFm-VhqVtH8aSGa1ghDuWr6Wrem6xhnohOMmUYRJUwLvdHCkEb1AKBoTfqe8JYSLozg1WVRHvvGA-ynTu6DHVR4kV5ZeXra5RtIVjFWicxfHfl98H8miEkONmpwTo3gpygJFpiTeccZrY-ozouLAcy5OcFyViPPanJJ5VFNjn05TZi6Afpz6L-LDHw9AXm5ypmgRm3jK8drXBHGX-cfvMue4s5NBwhyC8qlrcySccMbXFJMKJmrcvbeVv8Am_apWg</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Dávalos, Antoni</creator><creator>Pereira, Vitor Mendes</creator><creator>Chapot, René</creator><creator>Bonafé, Alain</creator><creator>Andersson, Tommy</creator><creator>Gralla, Jan</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20121001</creationdate><title>Retrospective Multicenter Study of Solitaire FR for Revascularization in the Treatment of Acute Ischemic Stroke</title><author>Dávalos, Antoni ; Pereira, Vitor Mendes ; Chapot, René ; Bonafé, Alain ; Andersson, Tommy ; Gralla, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5329-28879f8f26a7d4c9fbb5658b855f7a1a8f9edfc8f17adeeea241dd1692168f863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Cardiovascular system</topic><topic>Cerebral Revascularization - instrumentation</topic><topic>Cerebral Revascularization - methods</topic><topic>Cerebrovascular Disorders - drug therapy</topic><topic>Equipment and Supplies - adverse effects</topic><topic>Europe</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Pharmacology. Drug treatments</topic><topic>Regional Blood Flow - physiology</topic><topic>Retrospective Studies</topic><topic>Stents - adverse effects</topic><topic>Stroke - physiopathology</topic><topic>Stroke - therapy</topic><topic>Thrombectomy - instrumentation</topic><topic>Thrombolytic Therapy - methods</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dávalos, Antoni</creatorcontrib><creatorcontrib>Pereira, Vitor Mendes</creatorcontrib><creatorcontrib>Chapot, René</creatorcontrib><creatorcontrib>Bonafé, Alain</creatorcontrib><creatorcontrib>Andersson, Tommy</creatorcontrib><creatorcontrib>Gralla, Jan</creatorcontrib><creatorcontrib>Solitaire Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dávalos, Antoni</au><au>Pereira, Vitor Mendes</au><au>Chapot, René</au><au>Bonafé, Alain</au><au>Andersson, Tommy</au><au>Gralla, Jan</au><aucorp>Solitaire Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective Multicenter Study of Solitaire FR for Revascularization in the Treatment of Acute Ischemic Stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>43</volume><issue>10</issue><spage>2699</spage><epage>2705</epage><pages>2699-2705</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>The purpose of this study was to evaluate safety and efficacy of the Solitaire FR device in the treatment of patients with acute ischemic stroke secondary to large artery occlusion.
We conducted a retrospective study of consecutive patients presenting with acute ischemic stroke treated with Solitaire FR as the first-line device to restore blood flow in 6 experienced European centers. This study was entirely funded and supported by Coviden Neurovascular. An independent Corelab determined modified Thrombolysis in Cerebral Infarction scores on the preprocedure and postprocedure angiograms. Complete revascularization was defined as modified Thrombolysis in Cerebral Infarction 2b or 3 post-Solitaire FR device use. Symptomatic intracranial hemorrhage was defined as parenchymal hemorrhage Type 2 associated with a decline of ≥ 4 points in the National Institutes of Health Stroke Scale score within 24 hours or causing death. Favorable functional outcome was considered as modified Rankin Scale score ≤ 2 at Day 90.
We studied 141 patients (mean age, 66 years; median National Institutes of Health Stroke Scale, 18); 74 patients received intravenous tissue-type plasminogen activator before endovascular treatment. Complete revascularization was achieved in 120 of 142 occlusion sites (85%) and good outcome in 77 of 141 (55%) patients. Good outcome was more frequent in patients treated with intravenous tissue-type plasminogen activator than in those without (66% versus 42%; P<0.01). Symptomatic intracranial hemorrhage was reported in 5 patients (4%) and 29 of 141 (20%) patients died or were lost during follow-up (3 cases).
This retrospective study with centralized evaluation shows that the use of Solitaire FR is safe and achieves good revascularization rates and functional outcomes in patients with acute ischemic stroke and large artery occlusion.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>22851547</pmid><doi>10.1161/STROKEAHA.112.663328</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2012-10, Vol.43 (10), p.2699-2705 |
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| source | MEDLINE; EZB Free E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online; American Heart Association; Journals@Ovid Complete |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Brain - blood supply Cardiovascular system Cerebral Revascularization - instrumentation Cerebral Revascularization - methods Cerebrovascular Disorders - drug therapy Equipment and Supplies - adverse effects Europe Female Follow-Up Studies Humans Male Medical sciences Middle Aged Neurology Pharmacology. Drug treatments Regional Blood Flow - physiology Retrospective Studies Stents - adverse effects Stroke - physiopathology Stroke - therapy Thrombectomy - instrumentation Thrombolytic Therapy - methods Tissue Plasminogen Activator - therapeutic use Treatment Outcome Vascular diseases and vascular malformations of the nervous system Vasodilator agents. Cerebral vasodilators |
| title | Retrospective Multicenter Study of Solitaire FR for Revascularization in the Treatment of Acute Ischemic Stroke |
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