Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents

Ghrelin is a gastrointestinal polypeptide that acts through the ghrelin receptor (GHSR) to promote food intake and increase adiposity. Activation of GHSR requires the presence of a fatty-acid (FA) side chain on amino acid residue serine 3 of the ghrelin molecule. However, little is known about the r...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-10, Vol.153 (10), p.4687-4695
Hauptverfasser:	Heppner, Kristy M, Chaudhary, Nilika, Müller, Timo D, Kirchner, Henriette, Habegger, Kirk M, Ottaway, Nickki, Smiley, David L, DiMarchi, Richard, Hofmann, Susanna M, Woods, Stephen C, Sivertsen, Bjørn, Holst, Birgitte, Pfluger, Paul T, Perez-Tilve, Diego, Tschöp, Matthias H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Adipose tissue Amino acid composition Amino acids Animals Biological and medical sciences Body composition Body Composition - drug effects Body weight Body Weight - drug effects Eating - drug effects Energy balance Energy Balance-Obesity Energy Metabolism - drug effects Fatty acids Food Food availability Food chains Food composition Food intake Fundamental and applied biological sciences. Psychology Ghrelin Ghrelin - metabolism Ghrelin - pharmacology Homeostasis Homeostasis - drug effects In vivo methods and tests Male Mice Mice, Inbred C57BL Palmitic acid Peptides Polypeptides Protein Isoforms - metabolism Protein Isoforms - pharmacology Rats Rats, Long-Evans Receptors, Ghrelin - genetics Receptors, Ghrelin - metabolism Vertebrates: endocrinology
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