Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate

Objectives Tumour necrosis factor inhibition plus methotrexate is believed to inhibit radiographic progression independent of inflammation. This analysis assessed whether these protective effects are exerted on bone (joint erosion; JE) and/or cartilage (joint space narrowing; JSN), and what the inde...

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Veröffentlicht in:	Annals of the rheumatic diseases 2013-07, Vol.72 (7), p.1156-1162
Hauptverfasser:	Smolen, Josef S, van der Heijde, Désirée M, Keystone, Edward C, van Vollenhoven, Ronald F, Goldring, Mary B, Guérette, Benoît, Cifaldi, Mary A, Chen, Naijun, Liu, Shufang, Landewé, Robert B M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Adult Aged Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - drug therapy Cartilage, Articular - diagnostic imaging Clinical and Epidemiological Research Disease control Disease Progression Double-Blind Method Drug Therapy, Combination Employment Employment - statistics & numerical data Female Foot Joints - diagnostic imaging Hand Joints - diagnostic imaging Humans Inflammation Male Measurement techniques Methotrexate Methotrexate - therapeutic use Middle Aged Radiography Rheumatoid arthritis Treatment Outcome Tumor necrosis factor-TNF Work Capacity Evaluation
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