Association between adult height, genetic susceptibility and risk of glioma

Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated ef...

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Veröffentlicht in:	International journal of epidemiology 2012-08, Vol.41 (4), p.1075-1085
Hauptverfasser:	KITAHARA, Cari M, WANG, Sophia S, CARREON, Tania, FEYCHTING, Maria, GAPSTUR, Susan M, GAZIANO, J. Michael, GILES, Graham G, HALLMANS, Goran, HANKINSON, Susan E, HENRIKSSON, Roger, HSING, Ann W, JOHANSEN, Christoffer, MELIN, Beatrice S, LINET, Martha S, MCKEAN-COWDIN, Roberta, MICHAUD, Dominique S, PETERS, Ulrike, PURDUE, Mark P, ROTHMAN, Nathaniel, RUDER, Avima M, SESSO, Howard D, SEVERI, Gianluca, SHU, Xiao-Ou, ZHAOMING WANG, STEVENS, Victoria L, VISVANATHAN, Kala, WATERS, Martha A, WHITE, Emily, WOLK, Alicja, ZELENIUCH-JACQUOTTE, Anne, WEI ZHENG, HOOVER, Robert, FRAUMENI, Joseph F, CHATTERJEE, Nilanjan, BRAGANZA, Melissa, YEAGER, Meredith, CHANOCK, Stephen J, HARTGE, Patricia, RAJARAMAN, Preetha, INSKIP, Peter D, ALBANES, Demetrius, ANDERSSON, Ulrika, BEANE FREEMAN, Laura E, BURING, Julie E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Biomarkers, Tumor - analysis Body Height brain cancer Cancer Case-Control Studies Demography Epidemiology Female General aspects Genetic Predisposition to Disease Genetic Variation Genotype glioma Glioma - epidemiology Glioma - genetics Height Humans Logistic Models Male Medical sciences Middle Aged Miscellaneous Neurology Polymorphism, Single Nucleotide Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Sex Factors Surveys and Questionnaires Tumors of the nervous system. Phacomatoses
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container_title	International journal of epidemiology
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creator	KITAHARA, Cari M WANG, Sophia S CARREON, Tania FEYCHTING, Maria GAPSTUR, Susan M GAZIANO, J. Michael GILES, Graham G HALLMANS, Goran HANKINSON, Susan E HENRIKSSON, Roger HSING, Ann W JOHANSEN, Christoffer MELIN, Beatrice S LINET, Martha S MCKEAN-COWDIN, Roberta MICHAUD, Dominique S PETERS, Ulrike PURDUE, Mark P ROTHMAN, Nathaniel RUDER, Avima M SESSO, Howard D SEVERI, Gianluca SHU, Xiao-Ou ZHAOMING WANG STEVENS, Victoria L VISVANATHAN, Kala WATERS, Martha A WHITE, Emily WOLK, Alicja ZELENIUCH-JACQUOTTE, Anne WEI ZHENG HOOVER, Robert FRAUMENI, Joseph F CHATTERJEE, Nilanjan BRAGANZA, Melissa YEAGER, Meredith CHANOCK, Stephen J HARTGE, Patricia RAJARAMAN, Preetha INSKIP, Peter D ALBANES, Demetrius ANDERSSON, Ulrika BEANE FREEMAN, Laura E BURING, Julie E
description	Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. Among men, we found a positive association between height and glioma risk (≥ 190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥ 175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease.
doi_str_mv	10.1093/ije/dys114
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Michael ; GILES, Graham G ; HALLMANS, Goran ; HANKINSON, Susan E ; HENRIKSSON, Roger ; HSING, Ann W ; JOHANSEN, Christoffer ; MELIN, Beatrice S ; LINET, Martha S ; MCKEAN-COWDIN, Roberta ; MICHAUD, Dominique S ; PETERS, Ulrike ; PURDUE, Mark P ; ROTHMAN, Nathaniel ; RUDER, Avima M ; SESSO, Howard D ; SEVERI, Gianluca ; SHU, Xiao-Ou ; ZHAOMING WANG ; STEVENS, Victoria L ; VISVANATHAN, Kala ; WATERS, Martha A ; WHITE, Emily ; WOLK, Alicja ; ZELENIUCH-JACQUOTTE, Anne ; WEI ZHENG ; HOOVER, Robert ; FRAUMENI, Joseph F ; CHATTERJEE, Nilanjan ; BRAGANZA, Melissa ; YEAGER, Meredith ; CHANOCK, Stephen J ; HARTGE, Patricia ; RAJARAMAN, Preetha ; INSKIP, Peter D ; ALBANES, Demetrius ; ANDERSSON, Ulrika ; BEANE FREEMAN, Laura E ; BURING, Julie E</creator><creatorcontrib>KITAHARA, Cari M ; WANG, Sophia S ; CARREON, Tania ; FEYCHTING, Maria ; GAPSTUR, Susan M ; GAZIANO, J. Michael ; GILES, Graham G ; HALLMANS, Goran ; HANKINSON, Susan E ; HENRIKSSON, Roger ; HSING, Ann W ; JOHANSEN, Christoffer ; MELIN, Beatrice S ; LINET, Martha S ; MCKEAN-COWDIN, Roberta ; MICHAUD, Dominique S ; PETERS, Ulrike ; PURDUE, Mark P ; ROTHMAN, Nathaniel ; RUDER, Avima M ; SESSO, Howard D ; SEVERI, Gianluca ; SHU, Xiao-Ou ; ZHAOMING WANG ; STEVENS, Victoria L ; VISVANATHAN, Kala ; WATERS, Martha A ; WHITE, Emily ; WOLK, Alicja ; ZELENIUCH-JACQUOTTE, Anne ; WEI ZHENG ; HOOVER, Robert ; FRAUMENI, Joseph F ; CHATTERJEE, Nilanjan ; BRAGANZA, Melissa ; YEAGER, Meredith ; CHANOCK, Stephen J ; HARTGE, Patricia ; RAJARAMAN, Preetha ; INSKIP, Peter D ; ALBANES, Demetrius ; ANDERSSON, Ulrika ; BEANE FREEMAN, Laura E ; BURING, Julie E</creatorcontrib><description>Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. Among men, we found a positive association between height and glioma risk (≥ 190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥ 175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease.</description><identifier>ISSN: 0300-5771</identifier><identifier>ISSN: 1464-3685</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dys114</identifier><identifier>PMID: 22933650</identifier><identifier>CODEN: IJEPBF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Body Height ; brain cancer ; Cancer ; Case-Control Studies ; Demography ; Epidemiology ; Female ; General aspects ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; glioma ; Glioma - epidemiology ; Glioma - genetics ; Height ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Neurology ; Polymorphism, Single Nucleotide ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk ; Sex Factors ; Surveys and Questionnaires ; Tumors of the nervous system. Phacomatoses</subject><ispartof>International journal of epidemiology, 2012-08, Vol.41 (4), p.1075-1085</ispartof><rights>2015 INIST-CNRS</rights><rights>Published by Oxford University Press on behalf of the International Epidemiological Association 2012. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-2c775d891165d2a5c5607413b596339383679b1f35e6060db21c6542d6a247373</citedby><cites>FETCH-LOGICAL-c520t-2c775d891165d2a5c5607413b596339383679b1f35e6060db21c6542d6a247373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26318721$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22933650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60141$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422341$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:125198438$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>KITAHARA, Cari M</creatorcontrib><creatorcontrib>WANG, Sophia S</creatorcontrib><creatorcontrib>CARREON, Tania</creatorcontrib><creatorcontrib>FEYCHTING, Maria</creatorcontrib><creatorcontrib>GAPSTUR, Susan M</creatorcontrib><creatorcontrib>GAZIANO, J. Michael</creatorcontrib><creatorcontrib>GILES, Graham G</creatorcontrib><creatorcontrib>HALLMANS, Goran</creatorcontrib><creatorcontrib>HANKINSON, Susan E</creatorcontrib><creatorcontrib>HENRIKSSON, Roger</creatorcontrib><creatorcontrib>HSING, Ann W</creatorcontrib><creatorcontrib>JOHANSEN, Christoffer</creatorcontrib><creatorcontrib>MELIN, Beatrice S</creatorcontrib><creatorcontrib>LINET, Martha S</creatorcontrib><creatorcontrib>MCKEAN-COWDIN, Roberta</creatorcontrib><creatorcontrib>MICHAUD, Dominique S</creatorcontrib><creatorcontrib>PETERS, Ulrike</creatorcontrib><creatorcontrib>PURDUE, Mark P</creatorcontrib><creatorcontrib>ROTHMAN, Nathaniel</creatorcontrib><creatorcontrib>RUDER, Avima M</creatorcontrib><creatorcontrib>SESSO, Howard D</creatorcontrib><creatorcontrib>SEVERI, Gianluca</creatorcontrib><creatorcontrib>SHU, Xiao-Ou</creatorcontrib><creatorcontrib>ZHAOMING WANG</creatorcontrib><creatorcontrib>STEVENS, Victoria L</creatorcontrib><creatorcontrib>VISVANATHAN, Kala</creatorcontrib><creatorcontrib>WATERS, Martha A</creatorcontrib><creatorcontrib>WHITE, Emily</creatorcontrib><creatorcontrib>WOLK, Alicja</creatorcontrib><creatorcontrib>ZELENIUCH-JACQUOTTE, Anne</creatorcontrib><creatorcontrib>WEI ZHENG</creatorcontrib><creatorcontrib>HOOVER, Robert</creatorcontrib><creatorcontrib>FRAUMENI, Joseph F</creatorcontrib><creatorcontrib>CHATTERJEE, Nilanjan</creatorcontrib><creatorcontrib>BRAGANZA, Melissa</creatorcontrib><creatorcontrib>YEAGER, Meredith</creatorcontrib><creatorcontrib>CHANOCK, Stephen J</creatorcontrib><creatorcontrib>HARTGE, Patricia</creatorcontrib><creatorcontrib>RAJARAMAN, Preetha</creatorcontrib><creatorcontrib>INSKIP, Peter D</creatorcontrib><creatorcontrib>ALBANES, Demetrius</creatorcontrib><creatorcontrib>ANDERSSON, Ulrika</creatorcontrib><creatorcontrib>BEANE FREEMAN, Laura E</creatorcontrib><creatorcontrib>BURING, Julie E</creatorcontrib><title>Association between adult height, genetic susceptibility and risk of glioma</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. Among men, we found a positive association between height and glioma risk (≥ 190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥ 175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Body Height</subject><subject>brain cancer</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Demography</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>glioma</subject><subject>Glioma - epidemiology</subject><subject>Glioma - genetics</subject><subject>Height</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neurology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk</subject><subject>Sex Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0300-5771</issn><issn>1464-3685</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqN0ktv1DAQAGALgehSuPADUC5ICDXU9vgRX5BW5SkqcQGuluM4WbdJvLUdqv33eLVLoQckTrbszzOj8SD0nOA3BCs491fuvNslQtgDtCJMsBpEwx-iFQaMay4lOUFPUrrCmDDG1GN0QqkCEByv0Jd1SsF6k32Yq9blW-fmynTLmKuN88Mmn1WDm132tkpLsm6bfetHn3eVmbsq-nRdhb4aRh8m8xQ96s2Y3LPjeoq-f3j_7eJTffn14-eL9WVtOcW5plZK3jWKEME7arjlAktGoOVKAChoQEjVkh64E1jgrqXECs5oJwxlEiScovoQN9267dLqbfSTiTsdjNfHo-uyc5oDU1wUf_ZP_87_WOsQB70smlEKpY7_49OiRennnr898GIn11k352jGe6_u38x-o4fwUwOjqpH78l4dA8Rws7iU9eRLp8fRzC4sSRNCOBa0YXv6-kBtDClF19-lIVjvZ0GXWdCHWSj4xd-F3dHfn1_AyyMwyZqxj2a2Pv1xAkgjKYFfYWa95A</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>KITAHARA, Cari M</creator><creator>WANG, Sophia S</creator><creator>CARREON, Tania</creator><creator>FEYCHTING, Maria</creator><creator>GAPSTUR, Susan M</creator><creator>GAZIANO, J. 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Michael ; GILES, Graham G ; HALLMANS, Goran ; HANKINSON, Susan E ; HENRIKSSON, Roger ; HSING, Ann W ; JOHANSEN, Christoffer ; MELIN, Beatrice S ; LINET, Martha S ; MCKEAN-COWDIN, Roberta ; MICHAUD, Dominique S ; PETERS, Ulrike ; PURDUE, Mark P ; ROTHMAN, Nathaniel ; RUDER, Avima M ; SESSO, Howard D ; SEVERI, Gianluca ; SHU, Xiao-Ou ; ZHAOMING WANG ; STEVENS, Victoria L ; VISVANATHAN, Kala ; WATERS, Martha A ; WHITE, Emily ; WOLK, Alicja ; ZELENIUCH-JACQUOTTE, Anne ; WEI ZHENG ; HOOVER, Robert ; FRAUMENI, Joseph F ; CHATTERJEE, Nilanjan ; BRAGANZA, Melissa ; YEAGER, Meredith ; CHANOCK, Stephen J ; HARTGE, Patricia ; RAJARAMAN, Preetha ; INSKIP, Peter D ; ALBANES, Demetrius ; ANDERSSON, Ulrika ; BEANE FREEMAN, Laura E ; BURING, Julie E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-2c775d891165d2a5c5607413b596339383679b1f35e6060db21c6542d6a247373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Body Height</topic><topic>brain cancer</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Demography</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>glioma</topic><topic>Glioma - epidemiology</topic><topic>Glioma - genetics</topic><topic>Height</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neurology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk</topic><topic>Sex Factors</topic><topic>Surveys and Questionnaires</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KITAHARA, Cari M</creatorcontrib><creatorcontrib>WANG, Sophia S</creatorcontrib><creatorcontrib>CARREON, Tania</creatorcontrib><creatorcontrib>FEYCHTING, Maria</creatorcontrib><creatorcontrib>GAPSTUR, Susan M</creatorcontrib><creatorcontrib>GAZIANO, J. Michael</creatorcontrib><creatorcontrib>GILES, Graham G</creatorcontrib><creatorcontrib>HALLMANS, Goran</creatorcontrib><creatorcontrib>HANKINSON, Susan E</creatorcontrib><creatorcontrib>HENRIKSSON, Roger</creatorcontrib><creatorcontrib>HSING, Ann W</creatorcontrib><creatorcontrib>JOHANSEN, Christoffer</creatorcontrib><creatorcontrib>MELIN, Beatrice S</creatorcontrib><creatorcontrib>LINET, Martha S</creatorcontrib><creatorcontrib>MCKEAN-COWDIN, Roberta</creatorcontrib><creatorcontrib>MICHAUD, Dominique S</creatorcontrib><creatorcontrib>PETERS, Ulrike</creatorcontrib><creatorcontrib>PURDUE, Mark P</creatorcontrib><creatorcontrib>ROTHMAN, Nathaniel</creatorcontrib><creatorcontrib>RUDER, Avima M</creatorcontrib><creatorcontrib>SESSO, Howard D</creatorcontrib><creatorcontrib>SEVERI, Gianluca</creatorcontrib><creatorcontrib>SHU, Xiao-Ou</creatorcontrib><creatorcontrib>ZHAOMING WANG</creatorcontrib><creatorcontrib>STEVENS, Victoria L</creatorcontrib><creatorcontrib>VISVANATHAN, Kala</creatorcontrib><creatorcontrib>WATERS, Martha A</creatorcontrib><creatorcontrib>WHITE, Emily</creatorcontrib><creatorcontrib>WOLK, Alicja</creatorcontrib><creatorcontrib>ZELENIUCH-JACQUOTTE, Anne</creatorcontrib><creatorcontrib>WEI ZHENG</creatorcontrib><creatorcontrib>HOOVER, Robert</creatorcontrib><creatorcontrib>FRAUMENI, Joseph F</creatorcontrib><creatorcontrib>CHATTERJEE, Nilanjan</creatorcontrib><creatorcontrib>BRAGANZA, Melissa</creatorcontrib><creatorcontrib>YEAGER, Meredith</creatorcontrib><creatorcontrib>CHANOCK, Stephen J</creatorcontrib><creatorcontrib>HARTGE, Patricia</creatorcontrib><creatorcontrib>RAJARAMAN, Preetha</creatorcontrib><creatorcontrib>INSKIP, Peter D</creatorcontrib><creatorcontrib>ALBANES, Demetrius</creatorcontrib><creatorcontrib>ANDERSSON, Ulrika</creatorcontrib><creatorcontrib>BEANE FREEMAN, Laura E</creatorcontrib><creatorcontrib>BURING, Julie E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KITAHARA, Cari M</au><au>WANG, Sophia S</au><au>CARREON, Tania</au><au>FEYCHTING, Maria</au><au>GAPSTUR, Susan M</au><au>GAZIANO, J. Michael</au><au>GILES, Graham G</au><au>HALLMANS, Goran</au><au>HANKINSON, Susan E</au><au>HENRIKSSON, Roger</au><au>HSING, Ann W</au><au>JOHANSEN, Christoffer</au><au>MELIN, Beatrice S</au><au>LINET, Martha S</au><au>MCKEAN-COWDIN, Roberta</au><au>MICHAUD, Dominique S</au><au>PETERS, Ulrike</au><au>PURDUE, Mark P</au><au>ROTHMAN, Nathaniel</au><au>RUDER, Avima M</au><au>SESSO, Howard D</au><au>SEVERI, Gianluca</au><au>SHU, Xiao-Ou</au><au>ZHAOMING WANG</au><au>STEVENS, Victoria L</au><au>VISVANATHAN, Kala</au><au>WATERS, Martha A</au><au>WHITE, Emily</au><au>WOLK, Alicja</au><au>ZELENIUCH-JACQUOTTE, Anne</au><au>WEI ZHENG</au><au>HOOVER, Robert</au><au>FRAUMENI, Joseph F</au><au>CHATTERJEE, Nilanjan</au><au>BRAGANZA, Melissa</au><au>YEAGER, Meredith</au><au>CHANOCK, Stephen J</au><au>HARTGE, Patricia</au><au>RAJARAMAN, Preetha</au><au>INSKIP, Peter D</au><au>ALBANES, Demetrius</au><au>ANDERSSON, Ulrika</au><au>BEANE FREEMAN, Laura E</au><au>BURING, Julie E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between adult height, genetic susceptibility and risk of glioma</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>41</volume><issue>4</issue><spage>1075</spage><epage>1085</epage><pages>1075-1085</pages><issn>0300-5771</issn><issn>1464-3685</issn><eissn>1464-3685</eissn><coden>IJEPBF</coden><abstract>Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. Among men, we found a positive association between height and glioma risk (≥ 190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥ 175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22933650</pmid><doi>10.1093/ije/dys114</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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subjects	Aged Biological and medical sciences Biomarkers, Tumor - analysis Body Height brain cancer Cancer Case-Control Studies Demography Epidemiology Female General aspects Genetic Predisposition to Disease Genetic Variation Genotype glioma Glioma - epidemiology Glioma - genetics Height Humans Logistic Models Male Medical sciences Middle Aged Miscellaneous Neurology Polymorphism, Single Nucleotide Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Sex Factors Surveys and Questionnaires Tumors of the nervous system. Phacomatoses
title	Association between adult height, genetic susceptibility and risk of glioma
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