TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity

Virus-specific CTL with high levels of functional avidity have been associated with viral clearance in hepatitis C virus (HCV) infection and with enhanced protective immunity. In chronic HCV infection, lack of antiviral CTL is frequently observed. In this study, we aim to investigate novel HCV TCRs...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-11, Vol.189 (9), p.4510-4519
Hauptverfasser:	Pasetto, Anna, Frelin, Lars, Aleman, Soo, Holmström, Fredrik, Brass, Anette, Ahlén, Gustaf, Brenndörfer, Erwin D, Lohmann, Volker, Bartenschlager, Ralf, Sällberg, Matti, Bertoletti, Antonio, Chen, Margaret
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antiviral Agents - pharmacology Antiviral Agents - toxicity Cell Line Cell Line, Tumor Cytotoxicity, Immunologic - genetics Epitopes, T-Lymphocyte - physiology Epitopes, T-Lymphocyte - toxicity Female Gene Transfer Techniques Hepacivirus - immunology Hepacivirus - pathogenicity Hepatitis C virus Humans Leukocytes, Mononuclear - immunology Male Medicin och hälsovetenskap Mice Mice, Transgenic Molecular Sequence Data Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - physiology Transduction, Genetic - methods Virus Replication - genetics Virus Replication - immunology
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