Nuclear Stat5a/b predicts early recurrence and prostate cancer–specific death in patients treated by radical prostatectomy

Summary There is an urgent need for reliable markers to identify patients whose prostate cancer (PCa) will recur after initial therapy and progress to lethal disease. Gleason score (GS) is considered the most accurate predictive marker for disease-specific mortality after primary treatment of locali...

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Veröffentlicht in:	Human pathology 2013-03, Vol.44 (3), p.310-319
Hauptverfasser:	Mirtti, Tuomas, MD, PhD, Leiby, Benjamin E., PhD, Abdulghani, Junaid, MD, PhD, Aaltonen, Elina, MD, Pavela, Miia, MD, Mamtani, Anita, MD, Alanen, Kalle, MD, PhD, Egevad, Lars, MD, PhD, Granfors, Torvald, MD, PhD, Josefsson, Andreas, MD, PhD, Stattin, Par, MD, PhD, Bergh, Anders, MD, PhD, Nevalainen, Marja T., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cancer therapies Cell Nucleus Cloning Cohort Studies Disease Progression Follow-Up Studies Growth hormones Humans Male Middle Aged Neoplasm Grading Neoplasm Recurrence, Local Pathology Patients Predictive Value of Tests Prognosis Prospective Studies Prostate cancer Prostate cancer-specific death Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Proteins Recurrence STAT5 Transcription Factor - metabolism Stat5a/b Surgery Survival Analysis Therapy failure Treatment Outcome Tumor Suppressor Proteins - metabolism
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