Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages

LXR, an important inflammatory regulator, potently inhibits the formation of osteoclasts in a bacterial LPS environment. Bacterial‐induced bone diseases, such as periodontitis and osteomyelitis, are chronic inflammatory diseases characterized by increased bone destruction as a result of enhanced ost...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of leukocyte biology 2013-01, Vol.93 (1), p.71-82
Hauptverfasser:	Robertson Remen, Kirsten M., Lerner, Ulf H., Gustafsson, Jan‐Åke, Andersson, Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoates - pharmacology Benzylamines - pharmacology Blotting, Western bone resorption Bone Resorption - metabolism Cell Differentiation - drug effects Endocrinology and Diabetes Endokrinologi och diabetes inflammation Lipopolysaccharides - pharmacology Liver X Receptors LPS LXR Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout Orphan Nuclear Receptors - drug effects Orphan Nuclear Receptors - metabolism osteoclast Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Reverse Transcriptase Polymerase Chain Reaction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!