Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria

Abnormal splicing of LMNA gene or aberrant processing of prelamin A results in progeroid syndrome. Here we show that lamin A interacts with and activates SIRT1. SIRT1 exhibits reduced association with nuclear matrix (NM) and decreased deacetylase activity in the presence of progerin or prelamin A, l...

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Veröffentlicht in:	Cell metabolism 2012-12, Vol.16 (6), p.738-750
Hauptverfasser:	Liu, Baohua, Ghosh, Shrestha, Yang, Xi, Zheng, Huiling, Liu, Xinguang, Wang, Zimei, Jin, Guoxiang, Zheng, Bojian, Kennedy, Brian K., Suh, Yousin, Kaeberlein, Matt, Tryggvason, Karl, Zhou, Zhongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - drug effects Adult Stem Cells - metabolism Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Line Enzyme Activation - drug effects HEK293 Cells Humans Lamin Type A - genetics Lamin Type A - metabolism Longevity Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Metalloendopeptidases - deficiency Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Mice Mice, Knockout Nuclear Matrix - metabolism Nuclear Proteins - metabolism Progeria - metabolism Progeria - pathology Protein Binding Protein Precursors - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - pharmacology Sirtuin 1 - genetics Sirtuin 1 - metabolism Stilbenes - pharmacology
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