Dose-densified chemoimmunotherapy followed by systemic central nervous system prophylaxis for younger high-risk diffuse large B-cell/follicular grade 3 lymphoma patients: results of a phase II Nordic Lymphoma Group study

Many patients with aggressive B-cell lymphomas and high clinical risk score still die of lymphoma after conventional R-CHOP chemoimmunotherapy. We hypothesized that intensified chemoimmunotherapy including systemic central nervous system (CNS) prophylaxis improves outcome and reduces the incidence o...

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Veröffentlicht in:	Annals of oncology 2013-05, Vol.24 (5), p.1385-1392
Hauptverfasser:	Holte, H., Leppä, S., Björkholm, M., Fluge, Ø., Jyrkkiö, S., Delabie, J., Sundström, C., Karjalainen-Lindsberg, M.-L., Erlanson, M., Kolstad, A., Fosså, A., Østenstad, B., Löfvenberg, E., Nordström, M., Janes, R., Pedersen, L.M., Anderson, H., Jerkeman, M., Eriksson, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age age-adjusted IPI Antibodies, Monoclonal, Murine-Derived - therapeutic use Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cancer and Oncology Cancer och onkologi central nervous system Central Nervous System - drug effects Central Nervous System Neoplasms - drug therapy Central Nervous System Neoplasms - prevention & control Clinical Medicine Cyclophosphamide - therapeutic use Cytarabine - therapeutic use diffuse large B-cell lymphoma Doxorubicin - therapeutic use Etoposide - therapeutic use Female Hematologic and hematopoietic diseases Humans Immunotherapy intensive chemotherapy Klinisk medicin Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - mortality Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Middle Aged Neoplasm Recurrence, Local - drug therapy Pharmacology. Drug treatments Prednisone - therapeutic use prophylaxis Rituximab Vincristine - therapeutic use Young Adult
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