Interobserver variability of histopathological prognostic parameters in cutaneous malignant melanoma: impact on patient management
Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of th...
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| Veröffentlicht in: | Acta dermato-venereologica 2013-01, Vol.93 (4), p.411-416 |
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| creator | Eriksson, Hanna Frohm-Nilsson, Margareta Hedblad, Mari-Anne Hellborg, Henrik Kanter-Lewensohn, Lena Krawiec, Kamilla Lundh Rozell, Barbro Månsson-Brahme, Eva Hansson, Johan |
| description | Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to what extent the putative variability affected clinical management. A total of 234 cases of invasive cutaneous malignant melanoma were included in the study from the Stockholm-Gotland Healthcare Region in Sweden. Overall interobserver variability between a general pathologist and an expert review was 68.8-84.8%. Approximately 15.5% of melanomas ≤1 mm were re-classified either as melanoma in situ or melanomas >1 mm after review. In conclusion, review by a pathologist experienced in melanoma resulted in a change in recommendations about surgical excision margins and/or sentinel node biopsy in subgroups of T1 melanomas. |
| doi_str_mv | 10.2340/00015555-1517 |
| format | Article |
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The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to what extent the putative variability affected clinical management. A total of 234 cases of invasive cutaneous malignant melanoma were included in the study from the Stockholm-Gotland Healthcare Region in Sweden. Overall interobserver variability between a general pathologist and an expert review was 68.8-84.8%. Approximately 15.5% of melanomas ≤1 mm were re-classified either as melanoma in situ or melanomas >1 mm after review. In conclusion, review by a pathologist experienced in melanoma resulted in a change in recommendations about surgical excision margins and/or sentinel node biopsy in subgroups of T1 melanomas.</description><identifier>ISSN: 0001-5555</identifier><identifier>ISSN: 1651-2057</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.2340/00015555-1517</identifier><identifier>PMID: 23306667</identifier><language>eng</language><publisher>Sweden</publisher><subject>Cancer och onkologi ; Clinical Competence ; Dermatologi och venerologi ; Humans ; interobserver ; Klinisk medicin ; Medicin och hälsovetenskap ; melanoma ; Melanoma - pathology ; Melanoma - surgery ; Neoplasm Invasiveness ; Neoplasm Staging ; Observer Variation ; pathology ; Pathology - methods ; Predictive Value of Tests ; Prognosis ; Registries ; Reproducibility of Results ; Sentinel Lymph Node Biopsy ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Skin Ulcer - pathology ; Sweden ; treatment ; Tumor Burden ; variability</subject><ispartof>Acta dermato-venereologica, 2013-01, Vol.93 (4), p.411-416</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-850dcda58037e98c0c0feff1e151b77a44272d9b46e49bf528542f74940580573</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,552,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23306667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219890$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128183036$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Eriksson, Hanna</creatorcontrib><creatorcontrib>Frohm-Nilsson, Margareta</creatorcontrib><creatorcontrib>Hedblad, Mari-Anne</creatorcontrib><creatorcontrib>Hellborg, Henrik</creatorcontrib><creatorcontrib>Kanter-Lewensohn, Lena</creatorcontrib><creatorcontrib>Krawiec, Kamilla</creatorcontrib><creatorcontrib>Lundh Rozell, Barbro</creatorcontrib><creatorcontrib>Månsson-Brahme, Eva</creatorcontrib><creatorcontrib>Hansson, Johan</creatorcontrib><title>Interobserver variability of histopathological prognostic parameters in cutaneous malignant melanoma: impact on patient management</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to what extent the putative variability affected clinical management. A total of 234 cases of invasive cutaneous malignant melanoma were included in the study from the Stockholm-Gotland Healthcare Region in Sweden. Overall interobserver variability between a general pathologist and an expert review was 68.8-84.8%. Approximately 15.5% of melanomas ≤1 mm were re-classified either as melanoma in situ or melanomas >1 mm after review. In conclusion, review by a pathologist experienced in melanoma resulted in a change in recommendations about surgical excision margins and/or sentinel node biopsy in subgroups of T1 melanomas.</description><subject>Cancer och onkologi</subject><subject>Clinical Competence</subject><subject>Dermatologi och venerologi</subject><subject>Humans</subject><subject>interobserver</subject><subject>Klinisk medicin</subject><subject>Medicin och hälsovetenskap</subject><subject>melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Observer Variation</subject><subject>pathology</subject><subject>Pathology - methods</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Registries</subject><subject>Reproducibility of Results</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Skin Ulcer - pathology</subject><subject>Sweden</subject><subject>treatment</subject><subject>Tumor Burden</subject><subject>variability</subject><issn>0001-5555</issn><issn>1651-2057</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kr1v1TAUxS0Eoq-FkRV5ZCDgzzhmq1o-KlViAVbLcW5SQxIH22nVlb8cR--9dqoXX_ue35Hu1UHoDSUfGBfkIyGEynIqKql6hna0lrRiRKrnaLf1qq15gk5T-l2eTNLmJTphnJO6rtUO_buaM8TQJoi3EPGtjd62fvT5Hoce3_iUw2LzTRjD4J0d8RLDMIeUvcOLjXaCQifsZ-zWbGcIa8KTHf0w2znjCUY7h8l-wn5arMs4zIXKHraene0AUylfoRe9HRO8Ptxn6OeXzz8uvlXX379eXZxfV05IlatGks51VjaEK9CNI4700PcUyuCtUlYIplinW1GD0G0vWSMF65XQghRGKn6Gqr1vuoNlbc0S_WTjvQnWm8PXn1KBkZwxyopeP6kva-geoSNIWUMbTnhd2PdPspf-17kJcTDrahjVjSZF_m4vL75_V0jZTD45GMf9Sg3lWhMpma4fp3AxpBShf_CmxGyJMMdEmC0RRf_2YL22E3QP6mME-H9rAbTI</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Eriksson, Hanna</creator><creator>Frohm-Nilsson, Margareta</creator><creator>Hedblad, Mari-Anne</creator><creator>Hellborg, Henrik</creator><creator>Kanter-Lewensohn, Lena</creator><creator>Krawiec, Kamilla</creator><creator>Lundh Rozell, Barbro</creator><creator>Månsson-Brahme, Eva</creator><creator>Hansson, Johan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope></search><sort><creationdate>20130101</creationdate><title>Interobserver variability of histopathological prognostic parameters in cutaneous malignant melanoma: impact on patient management</title><author>Eriksson, Hanna ; Frohm-Nilsson, Margareta ; Hedblad, Mari-Anne ; Hellborg, Henrik ; Kanter-Lewensohn, Lena ; Krawiec, Kamilla ; Lundh Rozell, Barbro ; Månsson-Brahme, Eva ; Hansson, Johan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-850dcda58037e98c0c0feff1e151b77a44272d9b46e49bf528542f74940580573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cancer och onkologi</topic><topic>Clinical Competence</topic><topic>Dermatologi och venerologi</topic><topic>Humans</topic><topic>interobserver</topic><topic>Klinisk medicin</topic><topic>Medicin och hälsovetenskap</topic><topic>melanoma</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Observer Variation</topic><topic>pathology</topic><topic>Pathology - methods</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Registries</topic><topic>Reproducibility of Results</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Skin Ulcer - pathology</topic><topic>Sweden</topic><topic>treatment</topic><topic>Tumor Burden</topic><topic>variability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eriksson, Hanna</creatorcontrib><creatorcontrib>Frohm-Nilsson, Margareta</creatorcontrib><creatorcontrib>Hedblad, Mari-Anne</creatorcontrib><creatorcontrib>Hellborg, Henrik</creatorcontrib><creatorcontrib>Kanter-Lewensohn, Lena</creatorcontrib><creatorcontrib>Krawiec, Kamilla</creatorcontrib><creatorcontrib>Lundh Rozell, Barbro</creatorcontrib><creatorcontrib>Månsson-Brahme, Eva</creatorcontrib><creatorcontrib>Hansson, Johan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eriksson, Hanna</au><au>Frohm-Nilsson, Margareta</au><au>Hedblad, Mari-Anne</au><au>Hellborg, Henrik</au><au>Kanter-Lewensohn, Lena</au><au>Krawiec, Kamilla</au><au>Lundh Rozell, Barbro</au><au>Månsson-Brahme, Eva</au><au>Hansson, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interobserver variability of histopathological prognostic parameters in cutaneous malignant melanoma: impact on patient management</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>93</volume><issue>4</issue><spage>411</spage><epage>416</epage><pages>411-416</pages><issn>0001-5555</issn><issn>1651-2057</issn><eissn>1651-2057</eissn><abstract>Clinical management of primary cutaneous melanomas is based on histopathological staging of the tumour. The aim of this study was to investigate, in a non-selected population in clinical practice, the agreement rate between general pathologists and pathologists experienced in melanoma in terms of the evaluation of histopathological prognostic parameters in cutaneous malignant melanomas, and to what extent the putative variability affected clinical management. A total of 234 cases of invasive cutaneous malignant melanoma were included in the study from the Stockholm-Gotland Healthcare Region in Sweden. Overall interobserver variability between a general pathologist and an expert review was 68.8-84.8%. Approximately 15.5% of melanomas ≤1 mm were re-classified either as melanoma in situ or melanomas >1 mm after review. 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| ispartof | Acta dermato-venereologica, 2013-01, Vol.93 (4), p.411-416 |
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| source | MEDLINE; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cancer och onkologi Clinical Competence Dermatologi och venerologi Humans interobserver Klinisk medicin Medicin och hälsovetenskap melanoma Melanoma - pathology Melanoma - surgery Neoplasm Invasiveness Neoplasm Staging Observer Variation pathology Pathology - methods Predictive Value of Tests Prognosis Registries Reproducibility of Results Sentinel Lymph Node Biopsy Skin Neoplasms - pathology Skin Neoplasms - surgery Skin Ulcer - pathology Sweden treatment Tumor Burden variability |
| title | Interobserver variability of histopathological prognostic parameters in cutaneous malignant melanoma: impact on patient management |
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