Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality?

Twin studies have estimated the heritability of longevity to be approximately 20–30 %. Genome-wide association studies (GWAS) have revealed a large number of determinants of morbidity, but so far, no new polymorphisms have been discovered to be associated with longevity per se in GWAS. We aim to det...

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Veröffentlicht in:	Human genetics 2013-05, Vol.132 (5), p.553-561
Hauptverfasser:	Ganna, Andrea, Rivadeneira, Fernando, Hofman, Albert, Uitterlinden, André G., Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik, Tiemeier, Henning
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Cardiovascular disease Chromosomes Cohort Studies Colon Dementia Dementia - genetics Dementia - mortality Diabetes Diabetes Mellitus - genetics Diabetes Mellitus - mortality Epidemiology Female Follow-Up Studies Gene Function Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genomes Genomics Genotype Health aspects Health risk assessment Heart Diseases - genetics Heart Diseases - mortality Heart failure Human Genetics Humans Hypotheses Incidence Life expectancy Longevity - genetics Longevity - physiology Longitudinal Studies Male Medicin och hälsovetenskap Metabolic Diseases Middle Aged Molecular Medicine Mortality Multifactorial Inheritance - genetics Neoplasms - genetics Neoplasms - mortality Netherlands - epidemiology Original Investigation Phenotype Polymorphism, Single Nucleotide - genetics Prospective Studies Prostate Quality control Risk Factors Stroke Stroke - genetics Stroke - mortality Sweden - epidemiology Twins
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