Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Tenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Here, we demonstrate that in chronic lymphocytic leukemia (CLL)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2013-02, Vol.3 (1), p.1275, Article 1275
Hauptverfasser:	MacCallum, Stephanie F., Groves, Michael J., James, John, Murray, Karen, Appleyard, Virginia, Prescott, Alan R., Drbal, Abed A., Nicolaou, Anna, Cunningham, Joan, Haydock, Sally, Ganley, Ian G., Westwood, Nicholas J., Coates, Philip J., Lain, Sonia, Tauro, Sudhir
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/153 631/67/1990/283/1895 631/80/39/2346 692/308/1426 Aged Animals Autophagy Autophagy - drug effects Benzamides - toxicity Cells, Cultured Cytotoxicity Gene Expression Profiling Genes Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Humanities and Social Sciences Humans Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lysosomes - drug effects Lysosomes - metabolism Macrolides - toxicity Mice Microtubule-Associated Proteins - metabolism Middle Aged multidisciplinary Neoplastic Stem Cells - cytology Neoplastic Stem Cells - drug effects p53 Protein Science Signal transduction Sirtuins - antagonists & inhibitors Sirtuins - metabolism Tumor Suppressor Protein p53 - metabolism Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!