The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

Review of recent advances on post‐translational modifications that determine the role of HMGB1 as a cytokine mediator. HMGB1 is a ubiquitous nuclear protein present in almost all cell types. In addition to its intracellular functions, HMGB1 can be extracellularly released, where it mediates activati...

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Veröffentlicht in:	Journal of leukocyte biology 2013-06, Vol.93 (6), p.865-873
Hauptverfasser:	Yang, Huan, Antoine, Daniel J., Andersson, Ulf, Tracey, Kevin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation Animals Apoptosis - immunology Chemotaxis - immunology cysteine cytokine HMGB1 Protein - chemistry HMGB1 Protein - immunology HMGB1 Protein - metabolism Humans Inflammation - immunology Inflammation - metabolism Protein Processing, Post-Translational redox Reviews Structure-Activity Relationship
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