Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase
Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in the human lung. The degradation of single‐walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neit...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2013-08, Vol.9 (16), p.2721-2729 |
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| creator | Andón, Fernando T. Kapralov, Alexandr A. Yanamala, Naveena Feng, Weihong Baygan, Arjang Chambers, Benedict J. Hultenby, Kjell Ye, Fei Toprak, Muhammet S. Brandner, Birgit D. Fornara, Andrea Klein-Seetharaman, Judith Kotchey, Gregg P. Star, Alexander Shvedova, Anna A. Fadeel, Bengt Kagan, Valerian E. |
| description | Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in the human lung. The degradation of single‐walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV‐visible‐NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials.
Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant‐generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes. |
| doi_str_mv | 10.1002/smll.201202508 |
| format | Article |
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Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant‐generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.</description><identifier>ISSN: 1613-6810</identifier><identifier>ISSN: 1613-6829</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.201202508</identifier><identifier>PMID: 23447468</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Biodegra-dable materials ; biodegradable materials ; Biodegradation ; Biodegradation, Environmental ; carbon nanotubes ; Catalytic sites ; Confocal Raman imaging ; Culture systems ; Enzymes ; eosinophil peroxidase ; Eosinophil Peroxidase - metabolism ; Eosinophils - metabolism ; Humans ; Mice ; Microbiology ; molecular modeling ; Nanotechnology ; Nanotubes ; Nanotubes, Carbon - chemistry ; Near infrared spectroscopy ; Oxidants ; Oxidized groups ; Positively charged ; Respiratory system ; Single-walled carbon nanotube (SWCNTs) ; Single-walled carbon nanotubes (SWCN) ; Spectrum analysis ; Transmission electron microscopy</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2013-08, Vol.9 (16), p.2721-2729</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c8618-8bf62cbf09efdbab9fd586f5a8bcf548d91162c74d5c365a24416f8609ae54793</citedby><cites>FETCH-LOGICAL-c8618-8bf62cbf09efdbab9fd586f5a8bcf548d91162c74d5c365a24416f8609ae54793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsmll.201202508$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsmll.201202508$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23447468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-133837$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-27474$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:127859181$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Andón, Fernando T.</creatorcontrib><creatorcontrib>Kapralov, Alexandr A.</creatorcontrib><creatorcontrib>Yanamala, Naveena</creatorcontrib><creatorcontrib>Feng, Weihong</creatorcontrib><creatorcontrib>Baygan, Arjang</creatorcontrib><creatorcontrib>Chambers, Benedict J.</creatorcontrib><creatorcontrib>Hultenby, Kjell</creatorcontrib><creatorcontrib>Ye, Fei</creatorcontrib><creatorcontrib>Toprak, Muhammet S.</creatorcontrib><creatorcontrib>Brandner, Birgit D.</creatorcontrib><creatorcontrib>Fornara, Andrea</creatorcontrib><creatorcontrib>Klein-Seetharaman, Judith</creatorcontrib><creatorcontrib>Kotchey, Gregg P.</creatorcontrib><creatorcontrib>Star, Alexander</creatorcontrib><creatorcontrib>Shvedova, Anna A.</creatorcontrib><creatorcontrib>Fadeel, Bengt</creatorcontrib><creatorcontrib>Kagan, Valerian E.</creatorcontrib><title>Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in the human lung. The degradation of single‐walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV‐visible‐NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials.
Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant‐generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.</description><subject>Animals</subject><subject>Biodegra-dable materials</subject><subject>biodegradable materials</subject><subject>Biodegradation</subject><subject>Biodegradation, Environmental</subject><subject>carbon nanotubes</subject><subject>Catalytic sites</subject><subject>Confocal Raman imaging</subject><subject>Culture systems</subject><subject>Enzymes</subject><subject>eosinophil peroxidase</subject><subject>Eosinophil Peroxidase - metabolism</subject><subject>Eosinophils - metabolism</subject><subject>Humans</subject><subject>Mice</subject><subject>Microbiology</subject><subject>molecular modeling</subject><subject>Nanotechnology</subject><subject>Nanotubes</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Near infrared spectroscopy</subject><subject>Oxidants</subject><subject>Oxidized groups</subject><subject>Positively charged</subject><subject>Respiratory system</subject><subject>Single-walled carbon nanotube (SWCNTs)</subject><subject>Single-walled carbon nanotubes (SWCN)</subject><subject>Spectrum analysis</subject><subject>Transmission electron microscopy</subject><issn>1613-6810</issn><issn>1613-6829</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFks1vEzEQxVcIREvhyhGtxBFt8Nfa3gtSG9pQKZSPAJW4jLy7duLGWQd70zb_Pa4SVu0BOHk0_r031vhl2UuMRhgh8jaunBsRhAkiJZKPskPMMS24JNXjocboIHsW4xVCFBMmnmYHhDImGJeH2fmJ9a2eB9Wq3vou9yaf2W7udHGpnNNtPlahTv0L1fl-U-uY19v81Efb-fXCuvyzDv7Wtirq59kTo1zUL_bnUfb97PTb-EMx_TQ5Hx9Pi0ZyLAtZG06a2qBKm7ZWdWXaUnJTKlk3pmSyrTBOgGBt2VBeKsIY5kZyVCldMlHRo6zY-cYbvd7UsA52pcIWvLKwby1TpaGkGCOW-Dd_5d_bH8fgwxyCBSLSSv7pPtDLfgGYUklF4t_t-ASvdNvorg_KPZA9vOnsAub-GhiiFWI4GbzeGwT_a6NjD1d-E7q0QcCMMMoRqVCiRjuqCT7GoM0wASO4CwLcBQGGICTBq_vvGvA_P5-AagfcWKe3_7GD2cfp9L75fkk29vp20KqwBC6oKOHyYgJff_Ivs_GEgqC_AZz30Ok</recordid><startdate>20130826</startdate><enddate>20130826</enddate><creator>Andón, Fernando T.</creator><creator>Kapralov, Alexandr A.</creator><creator>Yanamala, Naveena</creator><creator>Feng, Weihong</creator><creator>Baygan, Arjang</creator><creator>Chambers, Benedict J.</creator><creator>Hultenby, Kjell</creator><creator>Ye, Fei</creator><creator>Toprak, Muhammet S.</creator><creator>Brandner, Birgit D.</creator><creator>Fornara, Andrea</creator><creator>Klein-Seetharaman, Judith</creator><creator>Kotchey, Gregg P.</creator><creator>Star, Alexander</creator><creator>Shvedova, Anna A.</creator><creator>Fadeel, Bengt</creator><creator>Kagan, Valerian E.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8V</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20130826</creationdate><title>Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase</title><author>Andón, Fernando T. ; Kapralov, Alexandr A. ; Yanamala, Naveena ; Feng, Weihong ; Baygan, Arjang ; Chambers, Benedict J. ; Hultenby, Kjell ; Ye, Fei ; Toprak, Muhammet S. ; Brandner, Birgit D. ; Fornara, Andrea ; Klein-Seetharaman, Judith ; Kotchey, Gregg P. ; Star, Alexander ; Shvedova, Anna A. ; Fadeel, Bengt ; Kagan, Valerian E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c8618-8bf62cbf09efdbab9fd586f5a8bcf548d91162c74d5c365a24416f8609ae54793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biodegra-dable materials</topic><topic>biodegradable materials</topic><topic>Biodegradation</topic><topic>Biodegradation, Environmental</topic><topic>carbon nanotubes</topic><topic>Catalytic sites</topic><topic>Confocal Raman imaging</topic><topic>Culture systems</topic><topic>Enzymes</topic><topic>eosinophil peroxidase</topic><topic>Eosinophil Peroxidase - metabolism</topic><topic>Eosinophils - metabolism</topic><topic>Humans</topic><topic>Mice</topic><topic>Microbiology</topic><topic>molecular modeling</topic><topic>Nanotechnology</topic><topic>Nanotubes</topic><topic>Nanotubes, Carbon - chemistry</topic><topic>Near infrared spectroscopy</topic><topic>Oxidants</topic><topic>Oxidized groups</topic><topic>Positively charged</topic><topic>Respiratory system</topic><topic>Single-walled carbon nanotube (SWCNTs)</topic><topic>Single-walled carbon nanotubes (SWCN)</topic><topic>Spectrum analysis</topic><topic>Transmission electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andón, Fernando T.</creatorcontrib><creatorcontrib>Kapralov, Alexandr A.</creatorcontrib><creatorcontrib>Yanamala, Naveena</creatorcontrib><creatorcontrib>Feng, Weihong</creatorcontrib><creatorcontrib>Baygan, Arjang</creatorcontrib><creatorcontrib>Chambers, Benedict J.</creatorcontrib><creatorcontrib>Hultenby, Kjell</creatorcontrib><creatorcontrib>Ye, Fei</creatorcontrib><creatorcontrib>Toprak, Muhammet S.</creatorcontrib><creatorcontrib>Brandner, Birgit D.</creatorcontrib><creatorcontrib>Fornara, Andrea</creatorcontrib><creatorcontrib>Klein-Seetharaman, Judith</creatorcontrib><creatorcontrib>Kotchey, Gregg P.</creatorcontrib><creatorcontrib>Star, Alexander</creatorcontrib><creatorcontrib>Shvedova, Anna A.</creatorcontrib><creatorcontrib>Fadeel, Bengt</creatorcontrib><creatorcontrib>Kagan, Valerian E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Kungliga Tekniska Högskolan</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andón, Fernando T.</au><au>Kapralov, Alexandr A.</au><au>Yanamala, Naveena</au><au>Feng, Weihong</au><au>Baygan, Arjang</au><au>Chambers, Benedict J.</au><au>Hultenby, Kjell</au><au>Ye, Fei</au><au>Toprak, Muhammet S.</au><au>Brandner, Birgit D.</au><au>Fornara, Andrea</au><au>Klein-Seetharaman, Judith</au><au>Kotchey, Gregg P.</au><au>Star, Alexander</au><au>Shvedova, Anna A.</au><au>Fadeel, Bengt</au><au>Kagan, Valerian E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2013-08-26</date><risdate>2013</risdate><volume>9</volume><issue>16</issue><spage>2721</spage><epage>2729</epage><pages>2721-2729</pages><issn>1613-6810</issn><issn>1613-6829</issn><eissn>1613-6829</eissn><abstract>Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in the human lung. The degradation of single‐walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H2O2 is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H2O2 alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV‐visible‐NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials.
Human eosinophil peroxidase (EPO) is able to degrade SWCNTs in vitro in the presence of H2O2. EPO is one of the major oxidant‐generating enzymes present in human lungs during inflammatory states. The biodegradation of SWCNTs is evidenced also in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. These results are relevant to potential respiratory exposure to carbon nanotubes.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23447468</pmid><doi>10.1002/smll.201202508</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Small (Weinheim an der Bergstrasse, Germany), 2013-08, Vol.9 (16), p.2721-2729 |
| issn | 1613-6810 1613-6829 1613-6829 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | Animals Biodegra-dable materials biodegradable materials Biodegradation Biodegradation, Environmental carbon nanotubes Catalytic sites Confocal Raman imaging Culture systems Enzymes eosinophil peroxidase Eosinophil Peroxidase - metabolism Eosinophils - metabolism Humans Mice Microbiology molecular modeling Nanotechnology Nanotubes Nanotubes, Carbon - chemistry Near infrared spectroscopy Oxidants Oxidized groups Positively charged Respiratory system Single-walled carbon nanotube (SWCNTs) Single-walled carbon nanotubes (SWCN) Spectrum analysis Transmission electron microscopy |
| title | Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase |
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