Identification of seven loci affecting mean telomere length and their association with disease

Nilesh Samani and colleagues report a meta-analysis of genome-wide association studies for mean leukocyte telomere length in 37,684 individuals, with replication of selected variants in an additional 10,739 individuals. They identify seven loci associated with mean telomere length, including two tha...

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Veröffentlicht in:	Nature genetics 2013-04, Vol.45 (4), p.422-427
Hauptverfasser:	Codd, Veryan, Nelson, Christopher P, Albrecht, Eva, Mangino, Massimo, Deelen, Joris, Buxton, Jessica L, Hottenga, Jouke Jan, Fischer, Krista, Esko, Tõnu, Surakka, Ida, Broer, Linda, Nyholt, Dale R, Leach, Irene Mateo, Salo, Perttu, Hägg, Sara, Matthews, Mary K, Palmen, Jutta, Norata, Giuseppe D, O'Reilly, Paul F, Saleheen, Danish, Amin, Najaf, Balmforth, Anthony J, Beekman, Marian, de Boer, Rudolf A, Böhringer, Stefan, Braund, Peter S, Burton, Paul R, Craen, Anton J Mde, Denniff, Matthew, Dong, Yanbin, Douroudis, Konstantinos, Dubinina, Elena, Eriksson, Johan G, Garlaschelli, Katia, Guo, Dehuang, Hartikainen, Anna-Liisa, Henders, Anjali K, Houwing-Duistermaat, Jeanine J, Kananen, Laura, Karssen, Lennart C, Kettunen, Johannes, Klopp, Norman, Lagou, Vasiliki, van Leeuwen, Elisabeth M, Madden, Pamela A, Mägi, Reedik, Magnusson, Patrik K E, Männistö, Satu, McCarthy, Mark I, Medland, Sarah E, Mihailov, Evelin, Montgomery, Grant W, Oostra, Ben A, Palotie, Aarno, Peters, Annette, Pollard, Helen, Pouta, Anneli, Prokopenko, Inga, Ripatti, Samuli, Salomaa, Veikko, Suchiman, H Eka D, Valdes, Ana M, Verweij, Niek, Viñuela, Ana, Wang, Xiaoling, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Margaret J, Xia, Kai, Xiao, Xiangjun, van Veldhuisen, Dirk J, Catapano, Alberico L, Tobin, Martin D, Hall, Alistair S, Blakemore, Alexandra I F, van Gilst, Wiek H, Zhu, Haidong, Erdmann, Jeanette, Reilly, Muredach P, Kathiresan, Sekar, Schunkert, Heribert, Talmud, Philippa J, Pedersen, Nancy L, Perola, Markus, Ouwehand, Willem, Kaprio, Jaakko, Martin, Nicholas G, van Duijn, Cornelia M, Hovatta, Iiris, Gieger, Christian, Metspalu, Andres, Boomsma, Dorret I, Jarvelin, Marjo-Riitta, Slagboom, P Eline, Thompson, John R, Spector, Tim D, van der Harst, Pim, Samani, Nilesh J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 631/337/103/560 692/699 Aging Agriculture Animal Genetics and Genomics Biomarkers, Tumor - genetics Biomedicine Cancer Research Case-Control Studies Chromosomes Deoxyribonucleic acid Disease - genetics DNA DNA polymerases Female Gene Function Gene therapy Genetic aspects Genetic Loci - genetics Genetic Predisposition to Disease Genetics Genome-Wide Association Study Human Genetics Humans letter Leukocytes - metabolism Male Meta-Analysis as Topic Physiological aspects Risk Factors Telomerase - genetics Telomere - genetics Telomeres
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