Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis

Deregulation of the hedgehog (HH) pathway results in overexpression of the GLI target BCL2 and is an initiating event in specific tumor types including basal cell carcinoma of the skin. Regulation of the HH pathway during keratinocyte differentiation is not well understood. We measured HH pathway ac...

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Veröffentlicht in:	Cell death and differentiation 2013-08, Vol.20 (8), p.1080-1088
Hauptverfasser:	Chari, N S, Romano, R A, Koster, M I, Jaks, V, Roop, D, Flores, E R, Teglund, S, Sinha, S, Gruber, W, Aberger, F, Medeiros, L J, Toftgard, R, McDonnell, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/67/1813/1349 631/80/86 Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell Differentiation - physiology Cell Line Cell Proliferation Cell Survival - physiology Cells, Cultured Epidermal Cells Epidermis - physiology Female Hedgehog Proteins - physiology Homeostasis Homeostasis - physiology In Vitro Techniques Keratinocytes - cytology Keratinocytes - physiology Life Sciences Ligands Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout Models, Animal Molecular biology Original Paper Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - physiology Proteins Proto-Oncogene Proteins c-bcl-2 - physiology Repressor Proteins - physiology Signal Transduction - physiology Skin cancer Stem Cells Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - physiology Transcription factors
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