Type I and II Endometrial Cancers: Have They Different Risk Factors?
Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We exa...
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| Veröffentlicht in: | Journal of clinical oncology 2013-07, Vol.31 (20), p.2607-2618 |
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| creator | SETIAWAN, Veronica Wendy YANG, Hannah P VAN DEN BRANDT, Piet A VAN DE VIJVER, Koen THOMPSON, Pamela J STROM, Brian L SPURDLE, Amanda B SOSLOW, Robert A SHU, Xiao-Ou SCHAIRER, Catherine SACERDOTE, Carlotta ROHAN, Thomas E PIKE, Malcolm C ROBIEN, Kim RISCH, Harvey A RICCERI, Fulvio REBBECK, Timothy R RASTOGI, Radhai PRESCOTT, Jennifer POLIDORO, Silvia PARK, Yikyung OLSON, Sara H MOYSICH, Kirsten B MCCANN, Susan E MILLER, Anthony B MCCULLOUGH, Marjorie L MATSUNO, Rayna K MAGLIOCCO, Anthony M LURIE, Galina LINGENG LU LISSOWSKA, Jolanta XIAOLIN LIANG LACEY, James V KOLONEL, Laurence N YU, Herbert HENDERSON, Brian E HANKINSON, Susan E HAKANSSON, Niclas GOODMAN, Marc T GAUDET, Mia M GARCIA-CLOSAS, Montserrat FRIEDENREICH, Christine M FREUDENHEIM, Jo L DOHERTY, Jennifer DE VIVO, Immaculata XIANG, Yong-Bing COURNEYA, Kerry S COOK, Linda S CHU CHEN CERHAN, James R HUI CAI BRINTON, Louise A BERNSTEIN, Leslie ANDERSON, Kristin E ANTON-CULVER, Hoda SCHOUTEN, Leo J WOLK, Alicja WENTZENSEN, Nicolas WEISS, Noel S WEBB, Penelope M |
| description | Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors.
Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors.
Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P heterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar.
The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed. |
| doi_str_mv | 10.1200/JCO.2012.48.2596 |
| format | Article |
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Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors.
Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P heterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar.
The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed.</description><identifier>ISSN: 0732-183X</identifier><identifier>ISSN: 1527-7755</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.2012.48.2596</identifier><identifier>PMID: 23733771</identifier><language>eng</language><publisher>Alexandria, VA: American Society of Clinical Oncology</publisher><subject>Adenocarcinoma - epidemiology ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Adult ; Age Factors ; Aged ; Biological and medical sciences ; Biopsy, Needle ; Carcinoma, Endometrioid - epidemiology ; Carcinoma, Endometrioid - pathology ; Carcinoma, Endometrioid - therapy ; Case-Control Studies ; Cohort Studies ; Confidence Intervals ; Contraceptives, Oral - adverse effects ; Databases, Factual ; Diabetes Mellitus - epidemiology ; Disease-Free Survival ; Endometrial Neoplasms - epidemiology ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - therapy ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Obesity - epidemiology ; Odds Ratio ; Original Reports ; Risk Factors ; Sensitivity and Specificity ; Smoking - epidemiology ; Survival Analysis ; Tumors</subject><ispartof>Journal of clinical oncology, 2013-07, Vol.31 (20), p.2607-2618</ispartof><rights>2014 INIST-CNRS</rights><rights>2013 by American Society of Clinical Oncology 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Fulvio</creatorcontrib><creatorcontrib>REBBECK, Timothy R</creatorcontrib><creatorcontrib>RASTOGI, Radhai</creatorcontrib><creatorcontrib>PRESCOTT, Jennifer</creatorcontrib><creatorcontrib>POLIDORO, Silvia</creatorcontrib><creatorcontrib>PARK, Yikyung</creatorcontrib><creatorcontrib>OLSON, Sara H</creatorcontrib><creatorcontrib>MOYSICH, Kirsten B</creatorcontrib><creatorcontrib>MCCANN, Susan E</creatorcontrib><creatorcontrib>MILLER, Anthony B</creatorcontrib><creatorcontrib>MCCULLOUGH, Marjorie L</creatorcontrib><creatorcontrib>MATSUNO, Rayna K</creatorcontrib><creatorcontrib>MAGLIOCCO, Anthony M</creatorcontrib><creatorcontrib>LURIE, Galina</creatorcontrib><creatorcontrib>LINGENG LU</creatorcontrib><creatorcontrib>LISSOWSKA, Jolanta</creatorcontrib><creatorcontrib>XIAOLIN LIANG</creatorcontrib><creatorcontrib>LACEY, James V</creatorcontrib><creatorcontrib>KOLONEL, Laurence N</creatorcontrib><creatorcontrib>YU, Herbert</creatorcontrib><creatorcontrib>HENDERSON, Brian E</creatorcontrib><creatorcontrib>HANKINSON, Susan E</creatorcontrib><creatorcontrib>HAKANSSON, Niclas</creatorcontrib><creatorcontrib>GOODMAN, Marc T</creatorcontrib><creatorcontrib>GAUDET, Mia M</creatorcontrib><creatorcontrib>GARCIA-CLOSAS, Montserrat</creatorcontrib><creatorcontrib>FRIEDENREICH, Christine M</creatorcontrib><creatorcontrib>FREUDENHEIM, Jo L</creatorcontrib><creatorcontrib>DOHERTY, Jennifer</creatorcontrib><creatorcontrib>DE VIVO, Immaculata</creatorcontrib><creatorcontrib>XIANG, Yong-Bing</creatorcontrib><creatorcontrib>COURNEYA, Kerry S</creatorcontrib><creatorcontrib>COOK, Linda S</creatorcontrib><creatorcontrib>CHU CHEN</creatorcontrib><creatorcontrib>CERHAN, James R</creatorcontrib><creatorcontrib>HUI CAI</creatorcontrib><creatorcontrib>BRINTON, Louise A</creatorcontrib><creatorcontrib>BERNSTEIN, Leslie</creatorcontrib><creatorcontrib>ANDERSON, Kristin E</creatorcontrib><creatorcontrib>ANTON-CULVER, Hoda</creatorcontrib><creatorcontrib>SCHOUTEN, Leo J</creatorcontrib><creatorcontrib>WOLK, Alicja</creatorcontrib><creatorcontrib>WENTZENSEN, Nicolas</creatorcontrib><creatorcontrib>WEISS, Noel S</creatorcontrib><creatorcontrib>WEBB, Penelope M</creatorcontrib><creatorcontrib>Australian National Endometrial Cancer Study Group</creatorcontrib><creatorcontrib>The Australian National Endometrial Cancer Study Group</creatorcontrib><title>Type I and II Endometrial Cancers: Have They Different Risk Factors?</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors.
Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors.
Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P heterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar.
The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed.</description><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Endometrioid - epidemiology</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Carcinoma, Endometrioid - therapy</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Databases, Factual</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Disease-Free Survival</subject><subject>Endometrial Neoplasms - epidemiology</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - therapy</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Obesity - epidemiology</subject><subject>Odds Ratio</subject><subject>Original Reports</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Smoking - epidemiology</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0732-183X</issn><issn>1527-7755</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kk1vEzEURS0EoqGwZ4W8QWyYYD_bYw-LoippaVClSiggdpbHH4nbyUxkJ63y73GUUOiClS373PtkHSP0lpIxBUI-fZvcjIFQGHM1BtHUz9CICpCVlEI8RyMiGVRUsV8n6FXOt4RQrph4iU6AScakpCM0ne_WHs-w6R2ezfBF74aV36RoOjwxvfUpf8ZX5t7j-dLv8DSG4JPvN_h7zHf40tjNkPKX1-hFMF32b47rKfpxeTGfXFXXN19nk_PrygpFNpV3HFRtlDTc-YZzEQz1zHFBLAjBWk55A1xY2rpA28bVruVKNT60nDtqAjtF1aE3P_j1ttXrFFcm7fRgoj4e3ZWd1wIawmXhP_6Xn8af53pIC73dag5AAAp-dsALu_LOlncm0z1JPb3p41IvhnvN6qaRUJcCciiwacg5-fCYpUTvhekiTO-Faa70XliJvPt35mPgj6ECvD8CJlvThVSsxPyXk4KRmojCfThwy7hYPsTkdV6Zriu1oG_twGiZq6EuX-I3oFGr0w</recordid><startdate>20130710</startdate><enddate>20130710</enddate><creator>SETIAWAN, Veronica Wendy</creator><creator>YANG, Hannah P</creator><creator>VAN DEN BRANDT, Piet A</creator><creator>VAN DE VIJVER, Koen</creator><creator>THOMPSON, Pamela J</creator><creator>STROM, Brian L</creator><creator>SPURDLE, Amanda B</creator><creator>SOSLOW, Robert A</creator><creator>SHU, Xiao-Ou</creator><creator>SCHAIRER, Catherine</creator><creator>SACERDOTE, Carlotta</creator><creator>ROHAN, Thomas E</creator><creator>PIKE, Malcolm C</creator><creator>ROBIEN, Kim</creator><creator>RISCH, Harvey A</creator><creator>RICCERI, Fulvio</creator><creator>REBBECK, Timothy R</creator><creator>RASTOGI, Radhai</creator><creator>PRESCOTT, Jennifer</creator><creator>POLIDORO, Silvia</creator><creator>PARK, Yikyung</creator><creator>OLSON, Sara H</creator><creator>MOYSICH, Kirsten B</creator><creator>MCCANN, Susan E</creator><creator>MILLER, Anthony B</creator><creator>MCCULLOUGH, Marjorie L</creator><creator>MATSUNO, Rayna K</creator><creator>MAGLIOCCO, Anthony M</creator><creator>LURIE, Galina</creator><creator>LINGENG LU</creator><creator>LISSOWSKA, Jolanta</creator><creator>XIAOLIN LIANG</creator><creator>LACEY, James V</creator><creator>KOLONEL, Laurence N</creator><creator>YU, Herbert</creator><creator>HENDERSON, Brian E</creator><creator>HANKINSON, Susan E</creator><creator>HAKANSSON, Niclas</creator><creator>GOODMAN, Marc T</creator><creator>GAUDET, Mia M</creator><creator>GARCIA-CLOSAS, Montserrat</creator><creator>FRIEDENREICH, Christine M</creator><creator>FREUDENHEIM, Jo L</creator><creator>DOHERTY, Jennifer</creator><creator>DE VIVO, Immaculata</creator><creator>XIANG, Yong-Bing</creator><creator>COURNEYA, Kerry S</creator><creator>COOK, Linda S</creator><creator>CHU CHEN</creator><creator>CERHAN, James R</creator><creator>HUI CAI</creator><creator>BRINTON, Louise A</creator><creator>BERNSTEIN, Leslie</creator><creator>ANDERSON, Kristin E</creator><creator>ANTON-CULVER, Hoda</creator><creator>SCHOUTEN, Leo J</creator><creator>WOLK, Alicja</creator><creator>WENTZENSEN, Nicolas</creator><creator>WEISS, Noel S</creator><creator>WEBB, Penelope M</creator><general>American Society of Clinical Oncology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20130710</creationdate><title>Type I and II Endometrial Cancers: Have They Different Risk Factors?</title><author>SETIAWAN, Veronica Wendy ; YANG, Hannah P ; VAN DEN BRANDT, Piet A ; VAN DE VIJVER, Koen ; THOMPSON, Pamela J ; STROM, Brian L ; SPURDLE, Amanda B ; SOSLOW, Robert A ; SHU, Xiao-Ou ; SCHAIRER, Catherine ; SACERDOTE, Carlotta ; ROHAN, Thomas E ; PIKE, Malcolm C ; ROBIEN, Kim ; RISCH, Harvey A ; RICCERI, Fulvio ; REBBECK, Timothy R ; RASTOGI, Radhai ; PRESCOTT, Jennifer ; POLIDORO, Silvia ; PARK, Yikyung ; OLSON, Sara H ; MOYSICH, Kirsten B ; MCCANN, Susan E ; MILLER, Anthony B ; MCCULLOUGH, Marjorie L ; MATSUNO, Rayna K ; MAGLIOCCO, Anthony M ; LURIE, Galina ; LINGENG LU ; LISSOWSKA, Jolanta ; XIAOLIN LIANG ; LACEY, James V ; KOLONEL, Laurence N ; YU, Herbert ; HENDERSON, Brian E ; HANKINSON, Susan E ; HAKANSSON, Niclas ; GOODMAN, Marc T ; GAUDET, Mia M ; GARCIA-CLOSAS, Montserrat ; FRIEDENREICH, Christine M ; FREUDENHEIM, Jo L ; DOHERTY, Jennifer ; DE VIVO, Immaculata ; XIANG, Yong-Bing ; COURNEYA, Kerry S ; COOK, Linda S ; CHU CHEN ; CERHAN, James R ; HUI CAI ; BRINTON, Louise A ; BERNSTEIN, Leslie ; ANDERSON, Kristin E ; ANTON-CULVER, Hoda ; SCHOUTEN, Leo J ; WOLK, Alicja ; WENTZENSEN, Nicolas ; WEISS, Noel S ; WEBB, Penelope M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-ed4286a87a4de9445fa1e3d450c2553b4149245c1bdf1b9d6db4889efb44d1af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Endometrioid - epidemiology</topic><topic>Carcinoma, Endometrioid - pathology</topic><topic>Carcinoma, Endometrioid - therapy</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>Databases, Factual</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Disease-Free Survival</topic><topic>Endometrial Neoplasms - epidemiology</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - therapy</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Obesity - epidemiology</topic><topic>Odds Ratio</topic><topic>Original Reports</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Smoking - epidemiology</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SETIAWAN, Veronica Wendy</creatorcontrib><creatorcontrib>YANG, Hannah P</creatorcontrib><creatorcontrib>VAN DEN BRANDT, Piet A</creatorcontrib><creatorcontrib>VAN DE VIJVER, Koen</creatorcontrib><creatorcontrib>THOMPSON, Pamela J</creatorcontrib><creatorcontrib>STROM, Brian L</creatorcontrib><creatorcontrib>SPURDLE, Amanda B</creatorcontrib><creatorcontrib>SOSLOW, Robert A</creatorcontrib><creatorcontrib>SHU, Xiao-Ou</creatorcontrib><creatorcontrib>SCHAIRER, Catherine</creatorcontrib><creatorcontrib>SACERDOTE, Carlotta</creatorcontrib><creatorcontrib>ROHAN, Thomas E</creatorcontrib><creatorcontrib>PIKE, Malcolm C</creatorcontrib><creatorcontrib>ROBIEN, Kim</creatorcontrib><creatorcontrib>RISCH, Harvey A</creatorcontrib><creatorcontrib>RICCERI, Fulvio</creatorcontrib><creatorcontrib>REBBECK, Timothy R</creatorcontrib><creatorcontrib>RASTOGI, Radhai</creatorcontrib><creatorcontrib>PRESCOTT, Jennifer</creatorcontrib><creatorcontrib>POLIDORO, Silvia</creatorcontrib><creatorcontrib>PARK, Yikyung</creatorcontrib><creatorcontrib>OLSON, Sara H</creatorcontrib><creatorcontrib>MOYSICH, Kirsten B</creatorcontrib><creatorcontrib>MCCANN, Susan E</creatorcontrib><creatorcontrib>MILLER, Anthony B</creatorcontrib><creatorcontrib>MCCULLOUGH, Marjorie L</creatorcontrib><creatorcontrib>MATSUNO, Rayna K</creatorcontrib><creatorcontrib>MAGLIOCCO, Anthony M</creatorcontrib><creatorcontrib>LURIE, Galina</creatorcontrib><creatorcontrib>LINGENG LU</creatorcontrib><creatorcontrib>LISSOWSKA, Jolanta</creatorcontrib><creatorcontrib>XIAOLIN LIANG</creatorcontrib><creatorcontrib>LACEY, James V</creatorcontrib><creatorcontrib>KOLONEL, Laurence N</creatorcontrib><creatorcontrib>YU, Herbert</creatorcontrib><creatorcontrib>HENDERSON, Brian E</creatorcontrib><creatorcontrib>HANKINSON, Susan E</creatorcontrib><creatorcontrib>HAKANSSON, Niclas</creatorcontrib><creatorcontrib>GOODMAN, Marc T</creatorcontrib><creatorcontrib>GAUDET, Mia M</creatorcontrib><creatorcontrib>GARCIA-CLOSAS, Montserrat</creatorcontrib><creatorcontrib>FRIEDENREICH, Christine M</creatorcontrib><creatorcontrib>FREUDENHEIM, Jo L</creatorcontrib><creatorcontrib>DOHERTY, Jennifer</creatorcontrib><creatorcontrib>DE VIVO, Immaculata</creatorcontrib><creatorcontrib>XIANG, Yong-Bing</creatorcontrib><creatorcontrib>COURNEYA, Kerry S</creatorcontrib><creatorcontrib>COOK, Linda S</creatorcontrib><creatorcontrib>CHU CHEN</creatorcontrib><creatorcontrib>CERHAN, James R</creatorcontrib><creatorcontrib>HUI CAI</creatorcontrib><creatorcontrib>BRINTON, Louise A</creatorcontrib><creatorcontrib>BERNSTEIN, Leslie</creatorcontrib><creatorcontrib>ANDERSON, Kristin E</creatorcontrib><creatorcontrib>ANTON-CULVER, Hoda</creatorcontrib><creatorcontrib>SCHOUTEN, Leo J</creatorcontrib><creatorcontrib>WOLK, Alicja</creatorcontrib><creatorcontrib>WENTZENSEN, Nicolas</creatorcontrib><creatorcontrib>WEISS, Noel S</creatorcontrib><creatorcontrib>WEBB, Penelope M</creatorcontrib><creatorcontrib>Australian National Endometrial Cancer Study Group</creatorcontrib><creatorcontrib>The Australian National Endometrial Cancer Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SETIAWAN, Veronica Wendy</au><au>YANG, Hannah P</au><au>VAN DEN BRANDT, Piet A</au><au>VAN DE VIJVER, Koen</au><au>THOMPSON, Pamela J</au><au>STROM, Brian L</au><au>SPURDLE, Amanda B</au><au>SOSLOW, Robert A</au><au>SHU, Xiao-Ou</au><au>SCHAIRER, Catherine</au><au>SACERDOTE, Carlotta</au><au>ROHAN, Thomas E</au><au>PIKE, Malcolm C</au><au>ROBIEN, Kim</au><au>RISCH, Harvey A</au><au>RICCERI, Fulvio</au><au>REBBECK, Timothy R</au><au>RASTOGI, Radhai</au><au>PRESCOTT, Jennifer</au><au>POLIDORO, Silvia</au><au>PARK, Yikyung</au><au>OLSON, Sara H</au><au>MOYSICH, Kirsten B</au><au>MCCANN, Susan E</au><au>MILLER, Anthony B</au><au>MCCULLOUGH, Marjorie L</au><au>MATSUNO, Rayna K</au><au>MAGLIOCCO, Anthony M</au><au>LURIE, Galina</au><au>LINGENG LU</au><au>LISSOWSKA, Jolanta</au><au>XIAOLIN LIANG</au><au>LACEY, James V</au><au>KOLONEL, Laurence N</au><au>YU, Herbert</au><au>HENDERSON, Brian E</au><au>HANKINSON, Susan E</au><au>HAKANSSON, Niclas</au><au>GOODMAN, Marc T</au><au>GAUDET, Mia M</au><au>GARCIA-CLOSAS, Montserrat</au><au>FRIEDENREICH, Christine M</au><au>FREUDENHEIM, Jo L</au><au>DOHERTY, Jennifer</au><au>DE VIVO, Immaculata</au><au>XIANG, Yong-Bing</au><au>COURNEYA, Kerry S</au><au>COOK, Linda S</au><au>CHU CHEN</au><au>CERHAN, James R</au><au>HUI CAI</au><au>BRINTON, Louise A</au><au>BERNSTEIN, Leslie</au><au>ANDERSON, Kristin E</au><au>ANTON-CULVER, Hoda</au><au>SCHOUTEN, Leo J</au><au>WOLK, Alicja</au><au>WENTZENSEN, Nicolas</au><au>WEISS, Noel S</au><au>WEBB, Penelope M</au><aucorp>Australian National Endometrial Cancer Study Group</aucorp><aucorp>The Australian National Endometrial Cancer Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type I and II Endometrial Cancers: Have They Different Risk Factors?</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>2013-07-10</date><risdate>2013</risdate><volume>31</volume><issue>20</issue><spage>2607</spage><epage>2618</epage><pages>2607-2618</pages><issn>0732-183X</issn><issn>1527-7755</issn><eissn>1527-7755</eissn><abstract>Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors.
Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors.
Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m(2) increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P heterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar.
The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed.</abstract><cop>Alexandria, VA</cop><pub>American Society of Clinical Oncology</pub><pmid>23733771</pmid><doi>10.1200/JCO.2012.48.2596</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-183X |
| ispartof | Journal of clinical oncology, 2013-07, Vol.31 (20), p.2607-2618 |
| issn | 0732-183X 1527-7755 1527-7755 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_529047 |
| source | MEDLINE; American Society of Clinical Oncology Online Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - epidemiology Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Age Factors Aged Biological and medical sciences Biopsy, Needle Carcinoma, Endometrioid - epidemiology Carcinoma, Endometrioid - pathology Carcinoma, Endometrioid - therapy Case-Control Studies Cohort Studies Confidence Intervals Contraceptives, Oral - adverse effects Databases, Factual Diabetes Mellitus - epidemiology Disease-Free Survival Endometrial Neoplasms - epidemiology Endometrial Neoplasms - pathology Endometrial Neoplasms - therapy Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness - pathology Neoplasm Staging Obesity - epidemiology Odds Ratio Original Reports Risk Factors Sensitivity and Specificity Smoking - epidemiology Survival Analysis Tumors |
| title | Type I and II Endometrial Cancers: Have They Different Risk Factors? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T09%3A32%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Type%20I%20and%20II%20Endometrial%20Cancers:%20Have%20They%20Different%20Risk%20Factors?&rft.jtitle=Journal%20of%20clinical%20oncology&rft.au=SETIAWAN,%20Veronica%20Wendy&rft.aucorp=Australian%20National%20Endometrial%20Cancer%20Study%20Group&rft.date=2013-07-10&rft.volume=31&rft.issue=20&rft.spage=2607&rft.epage=2618&rft.pages=2607-2618&rft.issn=0732-183X&rft.eissn=1527-7755&rft_id=info:doi/10.1200/JCO.2012.48.2596&rft_dat=%3Cpubmed_swepu%3E23733771%3C/pubmed_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23733771&rfr_iscdi=true |