Therapeutic DNA Vaccination Using In Vivo Electroporation Followed by Standard of Care Therapy in Patients With Genotype 1 Chronic Hepatitis C

Clearance of infections caused by the hepatitis C virus (HCV) correlates with HCV-specific T cell function. We therefore evaluated therapeutic vaccination in 12 patients with chronic HCV infection. Eight patients also underwent a subsequent standard-of-care (SOC) therapy with pegylated interferon (I...

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Veröffentlicht in:	Molecular therapy 2013-09, Vol.21 (9), p.1796-1805
Hauptverfasser:	Weiland, Ola, Ahlén, Gustaf, Diepolder, Helmut, Jung, Maria-Christina, Levander, Sepideh, Fons, Michael, Mathiesen, Iacob, Sardesai, Niranjan Y, Vahlne, Anders, Frelin, Lars, Sällberg, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Combined Modality Therapy Drug dosages Electroporation Female Genes Genotype & phenotype Hepacivirus - genetics Hepacivirus - immunology Hepacivirus - physiology Hepatitis C Hepatitis C virus Hepatitis C, Chronic - genetics Hepatitis C, Chronic - therapy Hepatitis C, Chronic - virology Hospitals Humans Infections Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Interferons Interleukins - genetics Lymphocyte Activation Lymphocytes Male Medicine Middle Aged Monkeys & apes Original Pain Peptides Polyethylene Glycols - administration & dosage Polyethylene Glycols - adverse effects Polyethylene Glycols - therapeutic use Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Ribavirin - administration & dosage Ribavirin - adverse effects Ribavirin - therapeutic use RNA, Viral - blood Standard of Care T-Lymphocytes - immunology Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - adverse effects Vaccines, DNA - immunology Vaccines, DNA - therapeutic use Vectors (Biology) Viral Hepatitis Vaccines - administration & dosage Viral Hepatitis Vaccines - adverse effects Viral Hepatitis Vaccines - therapeutic use Viral Load
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