Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)
The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Through the InterLymph Consortium, 12 case–control studies regarding cigarette smoking and HL w...
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| creator | Kamper-Jørgensen, M. Rostgaard, K. Glaser, S.L. Zahm, S.H. Cozen, W. Smedby, K.E. Sanjosé, S. Chang, E.T. Zheng, T. La Vecchia, C. Serraino, D. Monnereau, A. Kane, E.V. Miligi, L. Vineis, P. Spinelli, J.J. McLaughlin, J.R. Pahwa, P. Dosman, J.A. Vornanen, M. Foretova, L. Maynadie, M. Becker, N. Nieters, A. Brennan, P. Boffetta, P. Cocco, P. Hjalgrim, H. Staines, A. |
| description | The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes.
Through the InterLymph Consortium, 12 case–control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein–Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls.
Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01–1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29–1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27–2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90–1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72–1.44) was not increased.
These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified. |
| doi_str_mv | 10.1093/annonc/mdt218 |
| format | Article |
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Through the InterLymph Consortium, 12 case–control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein–Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls.
Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01–1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29–1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27–2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90–1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72–1.44) was not increased.
These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdt218</identifier><identifier>PMID: 23788758</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic agents ; Biological and medical sciences ; Case-Control Studies ; case–control ; cigarette smoking ; epidemiology ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - epidemiology ; Epstein–Barr virus ; Female ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - isolation & purification ; Hodgkin Disease - chemically induced ; Hodgkin Disease - epidemiology ; Hodgkin lymphoma ; Humans ; individual patient data meta-analysis ; Infectious diseases ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Life Sciences ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Reviews ; Risk ; Risk Factors ; Santé publique et épidémiologie ; Smoking - adverse effects ; Smoking - epidemiology ; Social Class ; Tobacco Use Disorder - complications ; Tobacco Use Disorder - epidemiology ; Tobacco, tobacco smoking ; Toxicology ; Viral diseases ; Young Adult</subject><ispartof>Annals of oncology, 2013-09, Vol.24 (9), p.2245-2255</ispartof><rights>2013 European Society for Medical Oncology</rights><rights>2014 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-56807baef1d2fe6adeb8188f71bda348a0ab6c263362e4239ff6496fbcba81983</citedby><cites>FETCH-LOGICAL-c603t-56807baef1d2fe6adeb8188f71bda348a0ab6c263362e4239ff6496fbcba81983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27697265$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23788758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01261737$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:127304373$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamper-Jørgensen, M.</creatorcontrib><creatorcontrib>Rostgaard, K.</creatorcontrib><creatorcontrib>Glaser, S.L.</creatorcontrib><creatorcontrib>Zahm, S.H.</creatorcontrib><creatorcontrib>Cozen, W.</creatorcontrib><creatorcontrib>Smedby, K.E.</creatorcontrib><creatorcontrib>Sanjosé, S.</creatorcontrib><creatorcontrib>Chang, E.T.</creatorcontrib><creatorcontrib>Zheng, T.</creatorcontrib><creatorcontrib>La Vecchia, C.</creatorcontrib><creatorcontrib>Serraino, D.</creatorcontrib><creatorcontrib>Monnereau, A.</creatorcontrib><creatorcontrib>Kane, E.V.</creatorcontrib><creatorcontrib>Miligi, L.</creatorcontrib><creatorcontrib>Vineis, P.</creatorcontrib><creatorcontrib>Spinelli, J.J.</creatorcontrib><creatorcontrib>McLaughlin, J.R.</creatorcontrib><creatorcontrib>Pahwa, P.</creatorcontrib><creatorcontrib>Dosman, J.A.</creatorcontrib><creatorcontrib>Vornanen, M.</creatorcontrib><creatorcontrib>Foretova, L.</creatorcontrib><creatorcontrib>Maynadie, M.</creatorcontrib><creatorcontrib>Becker, N.</creatorcontrib><creatorcontrib>Nieters, A.</creatorcontrib><creatorcontrib>Brennan, P.</creatorcontrib><creatorcontrib>Boffetta, P.</creatorcontrib><creatorcontrib>Cocco, P.</creatorcontrib><creatorcontrib>Hjalgrim, H.</creatorcontrib><creatorcontrib>Staines, A.</creatorcontrib><title>Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes.
Through the InterLymph Consortium, 12 case–control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein–Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls.
Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01–1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29–1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27–2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90–1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72–1.44) was not increased.
These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>case–control</subject><subject>cigarette smoking</subject><subject>epidemiology</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - epidemiology</subject><subject>Epstein–Barr virus</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Hodgkin Disease - chemically induced</subject><subject>Hodgkin Disease - epidemiology</subject><subject>Hodgkin lymphoma</subject><subject>Humans</subject><subject>individual patient data meta-analysis</subject><subject>Infectious diseases</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Reviews</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Santé publique et épidémiologie</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Social Class</subject><subject>Tobacco Use Disorder - complications</subject><subject>Tobacco Use Disorder - epidemiology</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Viral diseases</subject><subject>Young Adult</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kUtvEzEUhUcIRNPCki3yBokuhvqRsT0skKqokEqR2MDa8viRmMzYI9sJyi_h79bNpC1FYmXrnu8eHd1TVe8Q_IRgS66k98Grq0FnjPiLaoYa2tYcztHLagZbTGrWkPlZdZ7SLwghbXH7ujrDhHHOGj6r_izcWkaTswFpCFvn10B6DaJLWxAsWAa9LkPQH4ZxEwZ5FF1OIO26fBhN-gwkGEPojS6S7A_JJWBjGEDeGHDrs4leZheKBFYPHjej02ZwoQ_rA1gEn0LMbjeAj0f-iF2-qV5Z2Sfz9vReVD-_3vxYLOvV92-3i-tVrSgkuW4oh6yTxiKNraFSm44jzi1DnZZkziWUHVWYEkKxmWPSWkvnLbWd6iRHLScXVT35pt9m3HVijG6Q8SCCdOI02pafEQ3mlLaF_zLxRRmMVsbnKPtna88V7zZiHfaCsKYhBBeDy8lg88_a8nol7mcQYYoYYXv0FE7FkFI09nEBQXHfvpjaF1P7hX__d7hH-qHuAnw4ATIp2dsovXLpiWO0ZZg2hWMTZ8rp985EkZQzXhntolFZ6OD-E-EO5NPTcQ</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Kamper-Jørgensen, M.</creator><creator>Rostgaard, K.</creator><creator>Glaser, S.L.</creator><creator>Zahm, S.H.</creator><creator>Cozen, W.</creator><creator>Smedby, K.E.</creator><creator>Sanjosé, S.</creator><creator>Chang, E.T.</creator><creator>Zheng, T.</creator><creator>La Vecchia, C.</creator><creator>Serraino, D.</creator><creator>Monnereau, A.</creator><creator>Kane, E.V.</creator><creator>Miligi, L.</creator><creator>Vineis, P.</creator><creator>Spinelli, J.J.</creator><creator>McLaughlin, J.R.</creator><creator>Pahwa, P.</creator><creator>Dosman, J.A.</creator><creator>Vornanen, M.</creator><creator>Foretova, L.</creator><creator>Maynadie, M.</creator><creator>Becker, N.</creator><creator>Nieters, A.</creator><creator>Brennan, P.</creator><creator>Boffetta, P.</creator><creator>Cocco, P.</creator><creator>Hjalgrim, H.</creator><creator>Staines, A.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20130901</creationdate><title>Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)</title><author>Kamper-Jørgensen, M. ; Rostgaard, K. ; Glaser, S.L. ; Zahm, S.H. ; Cozen, W. ; Smedby, K.E. ; Sanjosé, S. ; Chang, E.T. ; Zheng, T. ; La Vecchia, C. ; Serraino, D. ; Monnereau, A. ; Kane, E.V. ; Miligi, L. ; Vineis, P. ; Spinelli, J.J. ; McLaughlin, J.R. ; Pahwa, P. ; Dosman, J.A. ; Vornanen, M. ; Foretova, L. ; Maynadie, M. ; Becker, N. ; Nieters, A. ; Brennan, P. ; Boffetta, P. ; Cocco, P. ; Hjalgrim, H. ; Staines, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-56807baef1d2fe6adeb8188f71bda348a0ab6c263362e4239ff6496fbcba81983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>case–control</topic><topic>cigarette smoking</topic><topic>epidemiology</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Epstein-Barr Virus Infections - epidemiology</topic><topic>Epstein–Barr virus</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Hodgkin Disease - chemically induced</topic><topic>Hodgkin Disease - epidemiology</topic><topic>Hodgkin lymphoma</topic><topic>Humans</topic><topic>individual patient data meta-analysis</topic><topic>Infectious diseases</topic><topic>Leukemias. 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Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes.
Through the InterLymph Consortium, 12 case–control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein–Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls.
Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01–1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29–1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27–2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90–1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72–1.44) was not increased.
These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>23788758</pmid><doi>10.1093/annonc/mdt218</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of oncology, 2013-09, Vol.24 (9), p.2245-2255 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adolescent Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Case-Control Studies case–control cigarette smoking epidemiology Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - epidemiology Epstein–Barr virus Female Hematologic and hematopoietic diseases Herpesvirus 4, Human - isolation & purification Hodgkin Disease - chemically induced Hodgkin Disease - epidemiology Hodgkin lymphoma Humans individual patient data meta-analysis Infectious diseases Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences Male Medical sciences Middle Aged Pharmacology. Drug treatments Reviews Risk Risk Factors Santé publique et épidémiologie Smoking - adverse effects Smoking - epidemiology Social Class Tobacco Use Disorder - complications Tobacco Use Disorder - epidemiology Tobacco, tobacco smoking Toxicology Viral diseases Young Adult |
| title | Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T21%3A48%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cigarette%20smoking%20and%20risk%20of%20Hodgkin%20lymphoma%20and%20its%20subtypes:%20a%20pooled%20analysis%20from%20the%20International%20Lymphoma%20Epidemiology%20Consortium%20(InterLymph)&rft.jtitle=Annals%20of%20oncology&rft.au=Kamper-J%C3%B8rgensen,%20M.&rft.date=2013-09-01&rft.volume=24&rft.issue=9&rft.spage=2245&rft.epage=2255&rft.pages=2245-2255&rft.issn=0923-7534&rft.eissn=1569-8041&rft_id=info:doi/10.1093/annonc/mdt218&rft_dat=%3Celsevier_swepu%3ES0923753419369480%3C/elsevier_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23788758&rft_els_id=S0923753419369480&rfr_iscdi=true |