Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans
According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2013-06, Vol.38 (6), p.1092-1104 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Libby, Peter Lichtman, Andrew H. Hansson, Göran K. |
| description | According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and link many traditional risk factors to altered arterial functions. Inflammatory pathways have become targets in the quest for novel preventive and therapeutic strategies against cardiovascular disease, a growing contributor to morbidity and mortality worldwide. Here we review current experimental and clinical knowledge of the pathogenesis of atherosclerosis through an immunological lens and how host defense mechanisms essential for survival of the species actually contribute to this chronic disease but also present new opportunities for its mitigation. |
| doi_str_mv | 10.1016/j.immuni.2013.06.009 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 27, 2013</rights><rights>2013 Elsevier Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-106d088c6446af89d44b1035f6266d4f142c30df1566f951365a0a7d37cdb7263</citedby><cites>FETCH-LOGICAL-c595t-106d088c6446af89d44b1035f6266d4f142c30df1566f951365a0a7d37cdb7263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1074761313002525$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23809160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128253101$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Libby, Peter</creatorcontrib><creatorcontrib>Lichtman, Andrew H.</creatorcontrib><creatorcontrib>Hansson, Göran K.</creatorcontrib><title>Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and link many traditional risk factors to altered arterial functions. Inflammatory pathways have become targets in the quest for novel preventive and therapeutic strategies against cardiovascular disease, a growing contributor to morbidity and mortality worldwide. Here we review current experimental and clinical knowledge of the pathogenesis of atherosclerosis through an immunological lens and how host defense mechanisms essential for survival of the species actually contribute to this chronic disease but also present new opportunities for its mitigation.</description><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>Arteries - metabolism</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - immunology</subject><subject>Atherosclerosis - therapy</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Clinical trials</subject><subject>Disease Models, Animal</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Inflammation - therapy</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Molecular Targeted Therapy</subject><subject>Mortality</subject><subject>Pathogenesis</subject><subject>Pattern recognition</subject><subject>Triglycerides</subject><subject>Veins & arteries</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kctu1DAUhiMEohd4A4QisWGTcBxfkrBAqqqWjtQRG1hbHvuE8RDbg5204u3raIZCWbCxLZ_v_OfyF8UbAjUBIj7sauvc7G3dAKE1iBqgf1acEujbipEOni_vllWtIPSkOEtpB0AY7-FlcdLQDnoi4LRYrxYRLK-GAfUUYrlGvVXeJpfKlduPVqsJTWl9eTFtMYakx-W06WN5HYMr11ZjOYXyZnbKp1fFi0GNCV8f7_Pi2_XV18ub6vbL59XlxW2lec-nioAw0HVaMCbU0PWGsQ0BygfRCGHYQFijKZiBcCGGnhMquALVGtpqs2kbQc-L6qCb7nE_b-Q-WqfiLxmUlcevH_mFkjcdp23mPx34HHFoNPopqvFJ2tOIt1v5PdxJ2grGAbLA-6NADD9nTJN0NmkcR-UxzEmSXITRpdOMvvsH3YU5-rwOSfLAbUYEzxQ7UDpvM0UcHpshIBd_5U4e_JWLvxKEzP7mtLd_D_KY9NvQP5NiXv-dxSiTtug1GhuzwdIE-_8KD-OAuGI</recordid><startdate>20130627</startdate><enddate>20130627</enddate><creator>Libby, Peter</creator><creator>Lichtman, Andrew H.</creator><creator>Hansson, Göran K.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20130627</creationdate><title>Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans</title><author>Libby, Peter ; 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| source | MEDLINE; Cell Press Archives; Elsevier ScienceDirect Journals Complete; SWEPUB Freely available online; EZB Electronic Journals Library |
| subjects | Adaptive Immunity Animals Arteries - metabolism Atherosclerosis Atherosclerosis - immunology Atherosclerosis - therapy Biomarkers Cardiovascular disease Cholesterol Cholesterol - metabolism Clinical trials Disease Models, Animal Heart attacks Humans Immunity, Innate Inflammation - therapy Lipids Lipoproteins Lymphocytes Mice Molecular Targeted Therapy Mortality Pathogenesis Pattern recognition Triglycerides Veins & arteries |
| title | Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans |
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