Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells

Peptidylarginine deiminase 4 (PAD4) is a Ca ²⁺-dependent enzyme that converts arginine and methylarginine residues to citrulline, with histone proteins being among its best-described substrates to date. However, the biological function of this posttranslational modification, either in histones or in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-07, Vol.110 (29), p.11851-11856
Hauptverfasser:	Stadler, Sonja C, Vincent, C Theresa, Fedorov, Victor D, Patsialou, Antonia, Cherrington, Brian D, Wakshlag, Joseph J, Mohanan, Sunish, Zee, Barry M, Zhang, Xuesen, Garcia, Benjamin A, Condeelis, John S, Brown, Anthony M C, Coonrod, Scott A, Allis, C David
Format:	Artikel
Sprache:	eng
Schlagworte:	arginine Biological Sciences breast neoplasms calcium Calcium Ionophores citrulline Citrulline - metabolism Epithelial-Mesenchymal Transition - physiology Fluorescent Antibody Technique Gene Knockdown Techniques glycogen (starch) synthase Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta histones Humans Hydrolases - metabolism Immunoblotting Immunohistochemistry Immunoprecipitation Mass Spectrometry MCF-7 Cells Microscopy, Interference Mutagenesis, Site-Directed neoplasm cells patients phenotype post-translational modification Protein-Arginine Deiminases Real-Time Polymerase Chain Reaction Signal Transduction - physiology Statistics, Nonparametric tau-protein kinase transcription factors transforming growth factor beta Transforming Growth Factor beta - metabolism
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