Construction and characterization of a new chimeric antibody against HER2

Immunotherapy with anti-HER2 antibodies has shown promising results in patients with HER2-positive breast cancer. We have recently reported characterization of a mouse monoclonal antibody (mAb) against HER2, which binds to an epitope different from that recognized by trastuzumab and specifically inh...

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Veröffentlicht in:	IMMUNOTHERAPY 2013-07, Vol.5 (7), p.703-715
Hauptverfasser:	Amiri, Mohammad Mehdi, Jeddi-Tehrani, Mahmood, Kazemi, Tohid, Bahadori, Motahareh, Maddah, Mahshid, Hojjat-Farsangi, Mohammad, Khoshnoodi, Jalal, Rabbani, Hodjatallah, Shokri, Fazel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Binding sites Biological activity Breast cancer Breast Neoplasms - immunology Breast Neoplasms - therapy Care and treatment Cell Proliferation Chemical properties chimeric antibody Deoxyribonucleic acid DNA Enzyme-linked immunosorbent assay Female Genetic aspects Health aspects HER2 Humans Hybridomas Immunization, Passive - methods Immunodominant Epitopes - immunology Kinases Mice Molecular Targeted Therapy Molecular weight Monoclonal antibodies monoclonal antibody Protein Engineering - methods Proteins Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - therapeutic use
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