An RNA modification with remarkable resistance to RNase A

A 3'-deoxy-3'-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. The most remarkable finding is that, despite the fact that both the vicinal 2-hydroxy nucleophile and the 5...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (79), p.9036-9038
Hauptverfasser:	Ghidini, Alice, Ander, Charlotte, Winqvist, Anna, Strömberg, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Degradation Nucleophiles Oligoribonucleotides - chemistry Phosphoric Diester Hydrolases - metabolism Phosphorous Acids - chemistry Ribonuclease, Pancreatic - metabolism Ribonucleic acids RNA - chemistry RNA - metabolism Snake Venoms - enzymology Spleen Venom toxins
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