Brain pathology after mild traumatic brain injury: an exploratory study by repeated magnetic resonance examination
To explore brain pathology after mild traumatic brain injury by repeated magnetic resonance examination. A prospective follow-up study. Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15. The patients were examined on day 2 or 3 and 3-7 months after the...
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| Veröffentlicht in: | Journal of rehabilitation medicine 2013-09, Vol.45 (8), p.721-728 |
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| container_title | Journal of rehabilitation medicine |
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| creator | Lannsjö, Marianne Raininko, Raili Bustamante, Mariana von Seth, Charlotta Borg, Jörgen |
| description | To explore brain pathology after mild traumatic brain injury by repeated magnetic resonance examination.
A prospective follow-up study.
Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15.
The patients were examined on day 2 or 3 and 3-7 months after the injury. The magnetic resonance protocol comprised conventional T1- and T2-weighted sequences including fluid attenuated inversion recovery (FLAIR), two susceptibility-weighted sequences to reveal haemorrhages, and diffusion-weighted sequences. Computer-aided volume comparison was performed. Clinical outcome was assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Hospital Anxiety and Depression Scale (HADS) and Glasgow Outcome Scale Extended (GOSE).
At follow-up, 7 patients (37%) reported ≥ 3 symptoms in RPQ, 5 reported some anxiety and 1 reported mild depression. Fifteen patients reported upper level of good recovery and 4 patients lower level of good recovery (GOSE 8 and 7, respectively). Magnetic resonance pathology was found in 1 patient at the first examination, but 4 patients (21%) showed volume loss at the second examination, at which 3 of them reported |
| doi_str_mv | 10.2340/16501977-1169 |
| format | Article |
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A prospective follow-up study.
Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15.
The patients were examined on day 2 or 3 and 3-7 months after the injury. The magnetic resonance protocol comprised conventional T1- and T2-weighted sequences including fluid attenuated inversion recovery (FLAIR), two susceptibility-weighted sequences to reveal haemorrhages, and diffusion-weighted sequences. Computer-aided volume comparison was performed. Clinical outcome was assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Hospital Anxiety and Depression Scale (HADS) and Glasgow Outcome Scale Extended (GOSE).
At follow-up, 7 patients (37%) reported ≥ 3 symptoms in RPQ, 5 reported some anxiety and 1 reported mild depression. Fifteen patients reported upper level of good recovery and 4 patients lower level of good recovery (GOSE 8 and 7, respectively). Magnetic resonance pathology was found in 1 patient at the first examination, but 4 patients (21%) showed volume loss at the second examination, at which 3 of them reported < 3 symptoms and 1 ≥ 3 symptoms, all exhibiting GOSE scores of 8.
Loss of brain volume, demonstrated by computer-aided magnetic resonance imaging volumetry, may be a feasible marker of brain pathology after mild traumatic brain injury.</description><identifier>ISSN: 1650-1977</identifier><identifier>ISSN: 1651-2081</identifier><identifier>EISSN: 1651-2081</identifier><identifier>DOI: 10.2340/16501977-1169</identifier><identifier>PMID: 24002306</identifier><language>eng</language><publisher>Sweden</publisher><subject>Adolescent ; Adult ; Anxiety-Depression ; Brain ; Brain - pathology ; Brain Injuries - diagnosis ; Brain Injuries - pathology ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Size ; Pathology ; Prospective Studies ; Sequences ; Symptoms ; Traumatic brain injury ; Young Adult</subject><ispartof>Journal of rehabilitation medicine, 2013-09, Vol.45 (8), p.721-728</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-299492e1dfdcd1cb491561c9c0f8dcec0db5dedb5381f91c420a8804154cf0ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902,30977</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24002306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207659$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:127679889$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Lannsjö, Marianne</creatorcontrib><creatorcontrib>Raininko, Raili</creatorcontrib><creatorcontrib>Bustamante, Mariana</creatorcontrib><creatorcontrib>von Seth, Charlotta</creatorcontrib><creatorcontrib>Borg, Jörgen</creatorcontrib><title>Brain pathology after mild traumatic brain injury: an exploratory study by repeated magnetic resonance examination</title><title>Journal of rehabilitation medicine</title><addtitle>J Rehabil Med</addtitle><description>To explore brain pathology after mild traumatic brain injury by repeated magnetic resonance examination.
A prospective follow-up study.
Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15.
The patients were examined on day 2 or 3 and 3-7 months after the injury. The magnetic resonance protocol comprised conventional T1- and T2-weighted sequences including fluid attenuated inversion recovery (FLAIR), two susceptibility-weighted sequences to reveal haemorrhages, and diffusion-weighted sequences. Computer-aided volume comparison was performed. Clinical outcome was assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Hospital Anxiety and Depression Scale (HADS) and Glasgow Outcome Scale Extended (GOSE).
At follow-up, 7 patients (37%) reported ≥ 3 symptoms in RPQ, 5 reported some anxiety and 1 reported mild depression. Fifteen patients reported upper level of good recovery and 4 patients lower level of good recovery (GOSE 8 and 7, respectively). Magnetic resonance pathology was found in 1 patient at the first examination, but 4 patients (21%) showed volume loss at the second examination, at which 3 of them reported < 3 symptoms and 1 ≥ 3 symptoms, all exhibiting GOSE scores of 8.
Loss of brain volume, demonstrated by computer-aided magnetic resonance imaging volumetry, may be a feasible marker of brain pathology after mild traumatic brain injury.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anxiety-Depression</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain Injuries - diagnosis</subject><subject>Brain Injuries - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Pathology</subject><subject>Prospective Studies</subject><subject>Sequences</subject><subject>Symptoms</subject><subject>Traumatic brain injury</subject><subject>Young Adult</subject><issn>1650-1977</issn><issn>1651-2081</issn><issn>1651-2081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>D8T</sourceid><recordid>eNqFks1v1jAMxiPExMbgyBXlyIGCnX6G2zbGhzRpl41rlCbuS0eblKQR9L9fu70bJ7RLbCc_P4rlh7E3CB9EXsBHrEpAWdcZYiWfsaO1xkxAg8_vcsi2x0P2MsYbAKzLvH7BDkUBIHKojlg4Dbp3fNLzTz_43cJ1N1PgYz9YPgedRj33hrd3UO9uUlg-ce04_Z0GH_Tsw8LjnOzC24UHmkjPZPmod462vkDRO-0MrQ167N0q5t0rdtDpIdLrfTxm11_Or86-ZReXX7-fnVxkpqjzORNSFlIQ2s4ai6YtJJYVGmmga6whA7YtLa1H3mAn0RQCdNNAgWVhOtA2P2bZvW78Q1Nq1RT6UYdFed2r_dWvNSNVihprufLv_8t_7n-cKB92KiUloK7KDX93j0_B_04UZzX20dAwaEc-RYUlCoHYyOZptKjWZdTVOvfTaA65LBuEf_OZ4GMM1D3-GEFt3lAP3lCbN1b-7V46tSPZR_rBDPktvW614w</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Lannsjö, Marianne</creator><creator>Raininko, Raili</creator><creator>Bustamante, Mariana</creator><creator>von Seth, Charlotta</creator><creator>Borg, Jörgen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope></search><sort><creationdate>20130901</creationdate><title>Brain pathology after mild traumatic brain injury: an exploratory study by repeated magnetic resonance examination</title><author>Lannsjö, Marianne ; Raininko, Raili ; Bustamante, Mariana ; von Seth, Charlotta ; Borg, Jörgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-299492e1dfdcd1cb491561c9c0f8dcec0db5dedb5381f91c420a8804154cf0ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anxiety-Depression</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain Injuries - diagnosis</topic><topic>Brain Injuries - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Pathology</topic><topic>Prospective Studies</topic><topic>Sequences</topic><topic>Symptoms</topic><topic>Traumatic brain injury</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lannsjö, Marianne</creatorcontrib><creatorcontrib>Raininko, Raili</creatorcontrib><creatorcontrib>Bustamante, Mariana</creatorcontrib><creatorcontrib>von Seth, Charlotta</creatorcontrib><creatorcontrib>Borg, Jörgen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>Journal of rehabilitation medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lannsjö, Marianne</au><au>Raininko, Raili</au><au>Bustamante, Mariana</au><au>von Seth, Charlotta</au><au>Borg, Jörgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain pathology after mild traumatic brain injury: an exploratory study by repeated magnetic resonance examination</atitle><jtitle>Journal of rehabilitation medicine</jtitle><addtitle>J Rehabil Med</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>45</volume><issue>8</issue><spage>721</spage><epage>728</epage><pages>721-728</pages><issn>1650-1977</issn><issn>1651-2081</issn><eissn>1651-2081</eissn><abstract>To explore brain pathology after mild traumatic brain injury by repeated magnetic resonance examination.
A prospective follow-up study.
Nineteen patients with mild traumatic brain injury presenting with Glasgow Coma Scale (GCS) 14-15.
The patients were examined on day 2 or 3 and 3-7 months after the injury. The magnetic resonance protocol comprised conventional T1- and T2-weighted sequences including fluid attenuated inversion recovery (FLAIR), two susceptibility-weighted sequences to reveal haemorrhages, and diffusion-weighted sequences. Computer-aided volume comparison was performed. Clinical outcome was assessed by the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Hospital Anxiety and Depression Scale (HADS) and Glasgow Outcome Scale Extended (GOSE).
At follow-up, 7 patients (37%) reported ≥ 3 symptoms in RPQ, 5 reported some anxiety and 1 reported mild depression. Fifteen patients reported upper level of good recovery and 4 patients lower level of good recovery (GOSE 8 and 7, respectively). Magnetic resonance pathology was found in 1 patient at the first examination, but 4 patients (21%) showed volume loss at the second examination, at which 3 of them reported < 3 symptoms and 1 ≥ 3 symptoms, all exhibiting GOSE scores of 8.
Loss of brain volume, demonstrated by computer-aided magnetic resonance imaging volumetry, may be a feasible marker of brain pathology after mild traumatic brain injury.</abstract><cop>Sweden</cop><pmid>24002306</pmid><doi>10.2340/16501977-1169</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of rehabilitation medicine, 2013-09, Vol.45 (8), p.721-728 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adolescent Adult Anxiety-Depression Brain Brain - pathology Brain Injuries - diagnosis Brain Injuries - pathology Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Middle Aged Organ Size Pathology Prospective Studies Sequences Symptoms Traumatic brain injury Young Adult |
| title | Brain pathology after mild traumatic brain injury: an exploratory study by repeated magnetic resonance examination |
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