Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design
High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear. We conducted a population-based cohort study via linkage of Swe...
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| Veröffentlicht in: | International journal of epidemiology 2014-02, Vol.43 (1), p.83-90 |
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| container_title | International journal of epidemiology |
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| creator | QI CHEN SJÖLANDER, Arvid LANGSTRÖM, Niklas RODRIGUEZ, Alina SERLACHIUS, Eva D'ONOFRIO, Brian M LICHTENSTEIN, Paul LARSSON, Henrik |
| description | High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear.
We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI |
| doi_str_mv | 10.1093/ije/dyt152 |
| format | Article |
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We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI <18.5; overweight: 25≤ BMI <30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding.
At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HR(overweight) = 1.23, 95% CI = 1.18-1.27, P = 0.01; HR(obesity) = 1.64, 95% CI = 1.57-1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HR(overweight) = 0.98, 95% CI = 0.83-1.16, P = 0.82; HR(obesity) = 1.15, 95% CI = 0.85-1.56, P = 0.38).
The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.</description><identifier>ISSN: 0300-5771</identifier><identifier>ISSN: 1464-3685</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyt152</identifier><identifier>PMID: 24058000</identifier><identifier>CODEN: IJEPBF</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>ADHD ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Biological and medical sciences ; Body Mass Index ; confounding ; Epidemiology ; Female ; Follow-Up Studies ; General aspects ; Humans ; Male ; Maternal Behavior - psychology ; maternal BMI ; Medical sciences ; Medicin och hälsovetenskap ; Mental Health ; Miscellaneous ; Mother-Child Relations ; Mothers - statistics & numerical data ; Obesity - epidemiology ; Population Surveillance ; Pregnancy ; prenatal ; Proportional Hazards Models ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; sibling comparison ; Siblings ; Surveys and Questionnaires ; Sweden - epidemiology</subject><ispartof>International journal of epidemiology, 2014-02, Vol.43 (1), p.83-90</ispartof><rights>2015 INIST-CNRS</rights><rights>Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2013; all rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c670t-d78e26350d23cc43a2f14a199d1fa395218fe173576951e299973198d4bb8b733</citedby><cites>FETCH-LOGICAL-c670t-d78e26350d23cc43a2f14a199d1fa395218fe173576951e299973198d4bb8b733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,552,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28228657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24058000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-21993$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54557$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128432752$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>QI CHEN</creatorcontrib><creatorcontrib>SJÖLANDER, Arvid</creatorcontrib><creatorcontrib>LANGSTRÖM, Niklas</creatorcontrib><creatorcontrib>RODRIGUEZ, Alina</creatorcontrib><creatorcontrib>SERLACHIUS, Eva</creatorcontrib><creatorcontrib>D'ONOFRIO, Brian M</creatorcontrib><creatorcontrib>LICHTENSTEIN, Paul</creatorcontrib><creatorcontrib>LARSSON, Henrik</creatorcontrib><title>Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear.
We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI <18.5; overweight: 25≤ BMI <30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding.
At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HR(overweight) = 1.23, 95% CI = 1.18-1.27, P = 0.01; HR(obesity) = 1.64, 95% CI = 1.57-1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HR(overweight) = 0.98, 95% CI = 0.83-1.16, P = 0.82; HR(obesity) = 1.15, 95% CI = 0.85-1.56, P = 0.38).
The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.</description><subject>ADHD</subject><subject>Attention Deficit Disorder with Hyperactivity - diagnosis</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>confounding</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Maternal Behavior - psychology</subject><subject>maternal BMI</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Mental Health</subject><subject>Miscellaneous</subject><subject>Mother-Child Relations</subject><subject>Mothers - statistics & numerical data</subject><subject>Obesity - epidemiology</subject><subject>Population Surveillance</subject><subject>Pregnancy</subject><subject>prenatal</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>sibling comparison</subject><subject>Siblings</subject><subject>Surveys and Questionnaires</subject><subject>Sweden - epidemiology</subject><issn>0300-5771</issn><issn>1464-3685</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk9vFCEYxidGY7fVix_AcDExjWP5OwweTJr6N6nxol4JA8wudRamwFTn2_hRZd3t1h5qPBAI_J6H94Wnqp4g-BJBQU7chT0xc0YM36sWiDa0Jk3L7lcLSCCsGefooDpM6QJCRCkVD6sDTCFrIYSL6tcnlW30agBjtHUZS6-8nkEXzAzWKiXgvLE_gfIGhL5PY3R-CVTO1mcXPDC2d9plsJpHG5XO7srlGRiXQjQ2vgIKjGGcBrWB604la4AOqxAzSHkqV0zpjx9IrhvKqtZhPapY5Bvr5Jb-UfWgV0Oyj3fzUfX13dsvZx_q88_vP56dnte64TDXhrcWN4RBg4nWlCjcI6qQEAb1igiGUdtbxAnjjWDIYiEEJ0i0hnZd23FCjqp665t-2HHqZGl0reIsg3Jyt_W9rKxkuOG0Kby4kx9jMDeiayHCLSWYM1y0L-7UvnHfTmWIyzImyShj_J-l7fG1m7zEpeFNK6-3fIHX1ujyVVENtyu8deLdSi7DlSSCcMFRMXi-M4jhcrIpF_ek7TAob8OUJGIIE0wa9D8opKhpBIcFPd6iOoaUou33FSEoN0GWJchyG-QCP_27hz16ndwCPNsBKmk19LHE1qUbrsW4bcrj_QbnLwLr</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>QI CHEN</creator><creator>SJÖLANDER, Arvid</creator><creator>LANGSTRÖM, Niklas</creator><creator>RODRIGUEZ, Alina</creator><creator>SERLACHIUS, Eva</creator><creator>D'ONOFRIO, Brian M</creator><creator>LICHTENSTEIN, Paul</creator><creator>LARSSON, Henrik</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7TS</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AKRZP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG5</scope><scope>ZZAVC</scope><scope>AABEP</scope><scope>D91</scope></search><sort><creationdate>20140201</creationdate><title>Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design</title><author>QI CHEN ; SJÖLANDER, Arvid ; LANGSTRÖM, Niklas ; RODRIGUEZ, Alina ; SERLACHIUS, Eva ; D'ONOFRIO, Brian M ; LICHTENSTEIN, Paul ; LARSSON, Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c670t-d78e26350d23cc43a2f14a199d1fa395218fe173576951e299973198d4bb8b733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>ADHD</topic><topic>Attention Deficit Disorder with Hyperactivity - diagnosis</topic><topic>Attention Deficit Disorder with Hyperactivity - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>confounding</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Maternal Behavior - psychology</topic><topic>maternal BMI</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Mental Health</topic><topic>Miscellaneous</topic><topic>Mother-Child Relations</topic><topic>Mothers - statistics & numerical data</topic><topic>Obesity - epidemiology</topic><topic>Population Surveillance</topic><topic>Pregnancy</topic><topic>prenatal</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>sibling comparison</topic><topic>Siblings</topic><topic>Surveys and Questionnaires</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>QI CHEN</creatorcontrib><creatorcontrib>SJÖLANDER, Arvid</creatorcontrib><creatorcontrib>LANGSTRÖM, Niklas</creatorcontrib><creatorcontrib>RODRIGUEZ, Alina</creatorcontrib><creatorcontrib>SERLACHIUS, Eva</creatorcontrib><creatorcontrib>D'ONOFRIO, Brian M</creatorcontrib><creatorcontrib>LICHTENSTEIN, Paul</creatorcontrib><creatorcontrib>LARSSON, Henrik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Physical Education Index</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Mittuniversitetet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Mittuniversitetet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Örebro universitet full text</collection><collection>SWEPUB Örebro universitet</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>QI CHEN</au><au>SJÖLANDER, Arvid</au><au>LANGSTRÖM, Niklas</au><au>RODRIGUEZ, Alina</au><au>SERLACHIUS, Eva</au><au>D'ONOFRIO, Brian M</au><au>LICHTENSTEIN, Paul</au><au>LARSSON, Henrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>43</volume><issue>1</issue><spage>83</spage><epage>90</epage><pages>83-90</pages><issn>0300-5771</issn><issn>1464-3685</issn><eissn>1464-3685</eissn><coden>IJEPBF</coden><abstract>High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear.
We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI <18.5; overweight: 25≤ BMI <30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding.
At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HR(overweight) = 1.23, 95% CI = 1.18-1.27, P = 0.01; HR(obesity) = 1.64, 95% CI = 1.57-1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HR(overweight) = 0.98, 95% CI = 0.83-1.16, P = 0.82; HR(obesity) = 1.15, 95% CI = 0.85-1.56, P = 0.38).
The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>24058000</pmid><doi>10.1093/ije/dyt152</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of epidemiology, 2014-02, Vol.43 (1), p.83-90 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | ADHD Attention Deficit Disorder with Hyperactivity - diagnosis Attention Deficit Disorder with Hyperactivity - epidemiology Biological and medical sciences Body Mass Index confounding Epidemiology Female Follow-Up Studies General aspects Humans Male Maternal Behavior - psychology maternal BMI Medical sciences Medicin och hälsovetenskap Mental Health Miscellaneous Mother-Child Relations Mothers - statistics & numerical data Obesity - epidemiology Population Surveillance Pregnancy prenatal Proportional Hazards Models Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors sibling comparison Siblings Surveys and Questionnaires Sweden - epidemiology |
| title | Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design |
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