Shiga-like toxin binds with high avidity to multivalent O-linked blood group P1 determinants on mucin-type fusion proteins

The binding of Shiga-like toxin 1 (Stx1) and Shiga-like toxin 2 (Stx2) to a mucin-like fusion protein, P-selectin glycoprotein ligand-1/mouse IgG2b (PSGL-1/mIgG2b), carrying multiple copies of the blood group P1 determinant on O-glycans was investigated with western blot and the biosensor Biacore. C...

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Veröffentlicht in:	Glycobiology (Oxford) 2014-01, Vol.24 (1), p.26-38
Hauptverfasser:	Maria Cherian, Reeja, Gaunitz, Stefan, Nilsson, Anki, Liu, Jining, Karlsson, Niclas G, Holgersson, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood group P1 CHO Cells Clinical Medicine COLONIZATION Columbidae Cricetinae Cricetulus CRYSTAL-STRUCTURE Globosides - chemistry Globosides - genetics Globosides - metabolism GROUP-A HELICOBACTER-PYLORI HEMOLYTIC-UREMIC SYNDROME Humans Immunoglobulin G - chemistry Immunoglobulin G - genetics Immunoglobulin G - metabolism Klinisk medicin MAJOR GLYCOPROTEINS mass spectrometry Medicin och hälsovetenskap Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice mucin N-Acetylglucosaminyltransferases - chemistry N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism N-GLYCAN STRUCTURES PIGEON EGG-WHITE Polysaccharides - chemistry Polysaccharides - genetics Polysaccharides - metabolism Protein Binding Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Shiga Toxin 1 - chemistry Shiga Toxin 1 - genetics Shiga Toxin 1 - metabolism Shiga Toxin 2 - chemistry Shiga Toxin 2 - genetics Shiga Toxin 2 - metabolism Shiga-like toxin Shiga-Toxigenic Escherichia coli - chemistry Shiga-Toxigenic Escherichia coli - genetics Shiga-Toxigenic Escherichia coli - metabolism SHIGELLA-DYSENTERIAE SPR STREPTOCOCCUS-SUIS UROPATHOGENIC ESCHERICHIA-COLI
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