Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts
Background Evidence on the long-term effects of air pollution exposure on childhood allergy is limited. Objective We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life. Method...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2014-03, Vol.133 (3), p.767-776.e7 |
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| creator | Gruzieva, Olena, MD, PhD Gehring, Ulrike, PhD Aalberse, Rob, PhD Agius, Raymond, MD, DM Beelen, Rob, PhD Behrendt, Heidrun, MD, PhD Bellander, Tom, PhD Birk, Matthias, MSc de Jongste, Johan C., MD, PhD Fuertes, Elaine, MSc Heinrich, Joachim, PhD Hoek, Gerard, PhD Klümper, Claudia, DrPH Koppelman, Gerard, MD, PhD Korek, Michal, MSc Krämer, Ursula, PhD Lindley, Sarah, PhD Mölter, Anna, PhD Simpson, Angela, MD, PhD Standl, Marie, PhD van Hage, Marianne, MD, PhD von Berg, Andrea, MD Wijga, Alet, PhD Brunekreef, Bert, PhD Pershagen, Göran, MD, PhD |
| description | Background Evidence on the long-term effects of air pollution exposure on childhood allergy is limited. Objective We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life. Methods Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5 ), the mass concentration of particles between 2.5 and 10 μm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 μm (PM10 ), as well as measurement of the blackness of PM2.5 filters and nitrogen dioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis. Results The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 × 10−5 ∙ m−1 increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 μg/m3 increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status. Conclusion No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed. |
| doi_str_mv | 10.1016/j.jaci.2013.07.048 |
| format | Article |
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Objective We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life. Methods Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5 ), the mass concentration of particles between 2.5 and 10 μm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 μm (PM10 ), as well as measurement of the blackness of PM2.5 filters and nitrogen dioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis. Results The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 × 10−5 ∙ m−1 increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 μg/m3 increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status. Conclusion No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.07.048</identifier><identifier>PMID: 24094547</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age ; Air pollution ; Air Pollution - adverse effects ; Allergy and Immunology ; Biological and medical sciences ; Child ; Child, Preschool ; children ; cohort ; Cohort Studies ; European Study of Cohorts for Air Pollution Effects ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hypersensitivity - etiology ; IgE ; Immunoglobulin E - blood ; Immunopathology ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Medical sciences ; meta-analysis ; Nitric Oxide - analysis ; Nitrogen dioxide ; Pollutants ; Prospective Studies ; Recruitment ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; sensitization ; Socioeconomic factors ; Studies</subject><ispartof>Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.767-776.e7</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-edb8dae86dcf2c2bfbbec13becb4c04a0f7c40aabe2eb70f982868896ebb256f3</citedby><cites>FETCH-LOGICAL-c584t-edb8dae86dcf2c2bfbbec13becb4c04a0f7c40aabe2eb70f982868896ebb256f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674913012992$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28383882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24094547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128610838$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruzieva, Olena, MD, PhD</creatorcontrib><creatorcontrib>Gehring, Ulrike, PhD</creatorcontrib><creatorcontrib>Aalberse, Rob, PhD</creatorcontrib><creatorcontrib>Agius, Raymond, MD, DM</creatorcontrib><creatorcontrib>Beelen, Rob, PhD</creatorcontrib><creatorcontrib>Behrendt, Heidrun, MD, PhD</creatorcontrib><creatorcontrib>Bellander, Tom, PhD</creatorcontrib><creatorcontrib>Birk, Matthias, MSc</creatorcontrib><creatorcontrib>de Jongste, Johan C., MD, PhD</creatorcontrib><creatorcontrib>Fuertes, Elaine, MSc</creatorcontrib><creatorcontrib>Heinrich, Joachim, PhD</creatorcontrib><creatorcontrib>Hoek, Gerard, PhD</creatorcontrib><creatorcontrib>Klümper, Claudia, DrPH</creatorcontrib><creatorcontrib>Koppelman, Gerard, MD, PhD</creatorcontrib><creatorcontrib>Korek, Michal, MSc</creatorcontrib><creatorcontrib>Krämer, Ursula, PhD</creatorcontrib><creatorcontrib>Lindley, Sarah, PhD</creatorcontrib><creatorcontrib>Mölter, Anna, PhD</creatorcontrib><creatorcontrib>Simpson, Angela, MD, PhD</creatorcontrib><creatorcontrib>Standl, Marie, PhD</creatorcontrib><creatorcontrib>van Hage, Marianne, MD, PhD</creatorcontrib><creatorcontrib>von Berg, Andrea, MD</creatorcontrib><creatorcontrib>Wijga, Alet, PhD</creatorcontrib><creatorcontrib>Brunekreef, Bert, PhD</creatorcontrib><creatorcontrib>Pershagen, Göran, MD, PhD</creatorcontrib><title>Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Evidence on the long-term effects of air pollution exposure on childhood allergy is limited. Objective We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life. Methods Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5 ), the mass concentration of particles between 2.5 and 10 μm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 μm (PM10 ), as well as measurement of the blackness of PM2.5 filters and nitrogen dioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis. Results The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 × 10−5 ∙ m−1 increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 μg/m3 increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status. Conclusion No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.</description><subject>Age</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Allergy and Immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>cohort</subject><subject>Cohort Studies</subject><subject>European Study of Cohorts for Air Pollution Effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hypersensitivity - etiology</subject><subject>IgE</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>meta-analysis</subject><subject>Nitric Oxide - analysis</subject><subject>Nitrogen dioxide</subject><subject>Pollutants</subject><subject>Prospective Studies</subject><subject>Recruitment</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>sensitization</subject><subject>Socioeconomic factors</subject><subject>Studies</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt2K1TAQx4so7nH1BbyQggjetCZp2qYggizrB6x4oV6HJJ16ptvT1Ezrenwan8UnM_Ucd2EvJJCPyW8mk_lPkjzmLOeMVy_6vDcOc8F4kbM6Z1LdSTacNXVWKVHeTTaMNTyratmcJA-IehbPhWruJydCskaWst4k_QeYTWZGM-wJKfVdajCkkx-GZUY_pvBj8rQESA2Rd2j-Gq9w3v7-ZYYBwld0KcFIOOPPwyWO6fkS_ARmTC2GeZs6v_VhpofJvc4MBI-O62ny5c3557N32cXHt-_PXl9krlRyzqC1qjWgqtZ1wgnbWQuOF3Gy0jFpWFc7yYyxIMDWrGuUUJVSTQXWirLqitMkO8SlK5gWq6eAOxP22hvUR9Nl3IEuRVWyIvLPD_wU_LcFaNY7JAfDYEbwC2lelbJqhKhX9OkttPdLiMVbKSlrVaqyjpQ4UC54ogDddQqc6VU53etVOb0qp1mto3LR6ckx9GJ30F67_JMqAs-OgCFnhi6Y0SHdcKqIQ4nIvTxwEGv8HSFocgijgxYDuFm3Hv-fx6tb7m7AEeOLl7AHuvmvJqGZ_rT22NpivGBcNI0o_gB8mNAx</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Gruzieva, Olena, MD, PhD</creator><creator>Gehring, Ulrike, PhD</creator><creator>Aalberse, Rob, PhD</creator><creator>Agius, Raymond, MD, DM</creator><creator>Beelen, Rob, PhD</creator><creator>Behrendt, Heidrun, MD, PhD</creator><creator>Bellander, Tom, PhD</creator><creator>Birk, Matthias, MSc</creator><creator>de Jongste, Johan C., MD, PhD</creator><creator>Fuertes, Elaine, MSc</creator><creator>Heinrich, Joachim, PhD</creator><creator>Hoek, Gerard, PhD</creator><creator>Klümper, Claudia, DrPH</creator><creator>Koppelman, Gerard, MD, PhD</creator><creator>Korek, Michal, MSc</creator><creator>Krämer, Ursula, PhD</creator><creator>Lindley, Sarah, PhD</creator><creator>Mölter, Anna, PhD</creator><creator>Simpson, Angela, MD, PhD</creator><creator>Standl, Marie, PhD</creator><creator>van Hage, Marianne, MD, PhD</creator><creator>von Berg, Andrea, MD</creator><creator>Wijga, Alet, PhD</creator><creator>Brunekreef, Bert, PhD</creator><creator>Pershagen, Göran, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TV</scope><scope>C1K</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20140301</creationdate><title>Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts</title><author>Gruzieva, Olena, MD, PhD ; Gehring, Ulrike, PhD ; Aalberse, Rob, PhD ; Agius, Raymond, MD, DM ; Beelen, Rob, PhD ; Behrendt, Heidrun, MD, PhD ; Bellander, Tom, PhD ; Birk, Matthias, MSc ; de Jongste, Johan C., MD, PhD ; Fuertes, Elaine, MSc ; Heinrich, Joachim, PhD ; Hoek, Gerard, PhD ; Klümper, Claudia, DrPH ; Koppelman, Gerard, MD, PhD ; Korek, Michal, MSc ; Krämer, Ursula, PhD ; Lindley, Sarah, PhD ; Mölter, Anna, PhD ; Simpson, Angela, MD, PhD ; Standl, Marie, PhD ; van Hage, Marianne, MD, PhD ; von Berg, Andrea, MD ; Wijga, Alet, PhD ; Brunekreef, Bert, PhD ; Pershagen, Göran, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-edb8dae86dcf2c2bfbbec13becb4c04a0f7c40aabe2eb70f982868896ebb256f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Allergy and Immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>cohort</topic><topic>Cohort Studies</topic><topic>European Study of Cohorts for Air Pollution Effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Hypersensitivity - etiology</topic><topic>IgE</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>meta-analysis</topic><topic>Nitric Oxide - analysis</topic><topic>Nitrogen dioxide</topic><topic>Pollutants</topic><topic>Prospective Studies</topic><topic>Recruitment</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>sensitization</topic><topic>Socioeconomic factors</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruzieva, Olena, MD, PhD</creatorcontrib><creatorcontrib>Gehring, Ulrike, PhD</creatorcontrib><creatorcontrib>Aalberse, Rob, PhD</creatorcontrib><creatorcontrib>Agius, Raymond, MD, DM</creatorcontrib><creatorcontrib>Beelen, Rob, PhD</creatorcontrib><creatorcontrib>Behrendt, Heidrun, MD, PhD</creatorcontrib><creatorcontrib>Bellander, Tom, PhD</creatorcontrib><creatorcontrib>Birk, Matthias, MSc</creatorcontrib><creatorcontrib>de Jongste, Johan C., MD, PhD</creatorcontrib><creatorcontrib>Fuertes, Elaine, MSc</creatorcontrib><creatorcontrib>Heinrich, Joachim, PhD</creatorcontrib><creatorcontrib>Hoek, Gerard, PhD</creatorcontrib><creatorcontrib>Klümper, Claudia, DrPH</creatorcontrib><creatorcontrib>Koppelman, Gerard, MD, PhD</creatorcontrib><creatorcontrib>Korek, Michal, MSc</creatorcontrib><creatorcontrib>Krämer, Ursula, PhD</creatorcontrib><creatorcontrib>Lindley, Sarah, PhD</creatorcontrib><creatorcontrib>Mölter, Anna, PhD</creatorcontrib><creatorcontrib>Simpson, Angela, MD, PhD</creatorcontrib><creatorcontrib>Standl, Marie, PhD</creatorcontrib><creatorcontrib>van Hage, Marianne, MD, PhD</creatorcontrib><creatorcontrib>von Berg, Andrea, MD</creatorcontrib><creatorcontrib>Wijga, Alet, PhD</creatorcontrib><creatorcontrib>Brunekreef, Bert, PhD</creatorcontrib><creatorcontrib>Pershagen, Göran, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Pollution Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruzieva, Olena, MD, PhD</au><au>Gehring, Ulrike, PhD</au><au>Aalberse, Rob, PhD</au><au>Agius, Raymond, MD, DM</au><au>Beelen, Rob, PhD</au><au>Behrendt, Heidrun, MD, PhD</au><au>Bellander, Tom, PhD</au><au>Birk, Matthias, MSc</au><au>de Jongste, Johan C., MD, PhD</au><au>Fuertes, Elaine, MSc</au><au>Heinrich, Joachim, PhD</au><au>Hoek, Gerard, PhD</au><au>Klümper, Claudia, DrPH</au><au>Koppelman, Gerard, MD, PhD</au><au>Korek, Michal, MSc</au><au>Krämer, Ursula, PhD</au><au>Lindley, Sarah, PhD</au><au>Mölter, Anna, PhD</au><au>Simpson, Angela, MD, PhD</au><au>Standl, Marie, PhD</au><au>van Hage, Marianne, MD, PhD</au><au>von Berg, Andrea, MD</au><au>Wijga, Alet, PhD</au><au>Brunekreef, Bert, PhD</au><au>Pershagen, Göran, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>133</volume><issue>3</issue><spage>767</spage><epage>776.e7</epage><pages>767-776.e7</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Evidence on the long-term effects of air pollution exposure on childhood allergy is limited. Objective We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life. Methods Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5 ), the mass concentration of particles between 2.5 and 10 μm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 μm (PM10 ), as well as measurement of the blackness of PM2.5 filters and nitrogen dioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis. Results The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 × 10−5 ∙ m−1 increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 μg/m3 increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status. Conclusion No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24094547</pmid><doi>10.1016/j.jaci.2013.07.048</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.767-776.e7 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_526503 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Air pollution Air Pollution - adverse effects Allergy and Immunology Biological and medical sciences Child Child, Preschool children cohort Cohort Studies European Study of Cohorts for Air Pollution Effects Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity - etiology IgE Immunoglobulin E - blood Immunopathology Infant Infant, Newborn Logistic Models Male Medical sciences meta-analysis Nitric Oxide - analysis Nitrogen dioxide Pollutants Prospective Studies Recruitment Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis sensitization Socioeconomic factors Studies |
| title | Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A27%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meta-analysis%20of%20air%20pollution%20exposure%20association%20with%C2%A0allergic%20sensitization%20in%20European%20birth%20cohorts&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Gruzieva,%20Olena,%20MD,%20PhD&rft.date=2014-03-01&rft.volume=133&rft.issue=3&rft.spage=767&rft.epage=776.e7&rft.pages=767-776.e7&rft.issn=0091-6749&rft.eissn=1097-6825&rft.coden=JACIBY&rft_id=info:doi/10.1016/j.jaci.2013.07.048&rft_dat=%3Cproquest_swepu%3E3556036091%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1644785857&rft_id=info:pmid/24094547&rft_els_id=1_s2_0_S0091674913012992&rfr_iscdi=true |